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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

acute myocardial infarction - myocardial revascularization - all type of patients

acute myocardial infarction - PCI - all type of patients


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WEST, 2006 - systematic PCI (+stent) vs no systematic PCI

TYPHOON, 2006 - sirolimus eluting stent vs bare-metal stent

ZWOLLE 6, 2005 - primary stenting vs balloon angioplasty

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See also:

  • All acute myocardial infarction clinical trials
  • All clinical trials of PCI
  • All clinical trials of systematic PCI (+stent)
  •  

    CAPITAL AMI study, 2005

    Facebook    pdf : systematic PCI (+stent) - myocardial revascularization for acute myocardial infarction

    Treatments

    Studied treatment TNK-facilitated angioplasty
    Control treatment TNK alone
    Treatments description
    stent (%) 89% 
    time from thrombolysisi to PCI in invasive arm 90 min 

    Patients

    Patients patients with high-risk ST-segment elevation myocardial infarction
    Baseline characteristics
    Age (year) 58 y 
    female (%) 25% 

    Method and design

    Randomized effectives 86 / 84 (studied vs. control)
    Design Parallel groups
    Follow-up duration 6 months
    Primary endpoint death, reinfarction, recurrent unstable ischemia, stroke


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    In-hospital death

    3 / 86
    3 / 84
    classic 0,98 [0,20;4,70]

    reinfarction

    5 / 86
    12 / 84
    0,41 [0,15;1,11]

    Major bleeding

    7 / 86
    6 / 84
    classic 1,14 [0,40;3,25]

    stroke (fatal and non fatal)

    1 / 86
    1 / 84
    classic 0,98 [0,06;15,36]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Ref
    Studied treat. Control treat.
    In-hospital death 3 / 86 (3,5%) 3 / 84 (3,6%) 0,98 [0,20;4,70]   9448 
    reinfarction 5 / 86 (5,8%) 12 / 84 (14,3%) 0,41 [0,15;1,11]   9448 
    Major bleeding 7 / 86 (8,1%) 6 / 84 (7,1%) 1,14 [0,40;3,25]   9448 
    stroke (fatal and non fatal) 1 / 86 (1,2%) 1 / 84 (1,2%) 0,98 [0,06;15,36]   9448 
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 9448: Wijeysundera HC, You JJ, Nallamothu BK, Krumholz HM, Cantor WJ, Ko DTAn early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: a meta-analysis of contemporary randomized controlled trials.Am Heart J 2008;156:564-572, 572.e1-2

  • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    In-hospital death 3,49% 3,57% -0,8‰
    reinfarction 5,81% 14,29% -84,7‰
    Major bleeding 8,14% 7,14% 10,0‰
    stroke (fatal and non fatal) 1,16% 1,19% -0,3‰

    Meta-analysis of all similar trials:

    myocardial revascularization in acute myocardial infarction for all type of patients

    PCI in acute myocardial infarction for all type of patients



    Reference(s)

    Trials register # NA
    • Le May MR, Wells GA, Labinaz M, Davies RF, Turek M, Leddy D, Maloney J, McKibbin T, Quinn B, Beanlands RS, Glover C, Marquis JF, O'Brien ER, Williams WL, Higginson LA. Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study).. J Am Coll Cardiol 2005;46:417-24
      Pubmed | Hubmed | Fulltext

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