acute myocardial infarction - PCI - all type of patients clinical trials results meta-analysis

<h1> <a href="index.html"> <strong>acute myocardial infarction</strong> - PCI </a> - all type of patients trial results systematic overview and meta-analysis </h1> <h2>Main characteristics of the included studies</h2> <table> <tr> <th>Trial</th> <th>Treatments</th> <th>Patients</th> <th>Methods</th> </tr> <tr> <td> <a href="index.html"> Zwolle, 1994 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> streptokinase 1.5 M IU over 1h </td> <td> patients with acute myocardial infarction </td> <td> follow-up discharge<br> n=152/149<br> Parallel groups<br> open <br> The Netherland </td> </tr> <tr> <td> <a href="index.html"> Ribeiro, 1993 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> streptokinase 1.2 M IU over 1h </td> <td> patients with ST segment elevation within 6 h of the onset of chest pain </td> <td> follow-up discharge<br> n=50/50<br> Parallel groups<br> open <br> Brazil </td> </tr> <tr> <td> <a href="index.html"> Grinfeld, 1996 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> streptokinase 1.5 M IU over 1h </td> <td> </td> <td> follow-up 30 d<br> n=54/58<br> Parallel groups<br> open <br> Argentina </td> </tr> <tr> <td> <a href="index.html"> Zijlstra, 1997 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> streptokinase 1.5 M IU over 1h </td> <td> atients with acute myocardial infarction </td> <td> follow-up 6 months<br> n=45/50<br> Parallel groups<br> open <br> The Netherland </td> </tr> <tr> <td> <a href="index.html"> DeWood, 1989 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> duteplase 0.5 MU/kg for 1 h then 0.7 MU/kg/h for 3h </td> <td> </td> <td> follow-up 30 d<br> n=46/44<br> Parallel groups<br> open <br> USA </td> </tr> <tr> <td> <a href="index.html"> PAMI, 1993 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> t-PA 100mg (or 1.25mg/kg for patients weighting less than 65kg) over 3 h </td> <td> patients who presented within 12 hours of the onset of myocardial infarction </td> <td> follow-up discharge<br> n=195/200<br> Parallel groups<br> open <br> USA,Europe </td> </tr> <tr> <td> <a href="index.html"> Gibbons, 1993 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> duteplase 0.6 MU/kg over 5h </td> <td> patients with acute myocardial infarction </td> <td> follow-up discharge<br> n=47/56<br> Parallel groups<br> open <br> USA </td> </tr> <tr> <td> <a href="index.html"> Ribichini, 1996 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> accelerated alteplase 90 min (15 mg IV bolus followed by an infusion of 0.75 mg/kg over 30min not to exceed 50mg, and then 0.5 mg/kg over the next 60min not to exceed 35mg for a total maximun of 100mg) </td> <td> </td> <td> follow-up discharge<br> n=24/26<br> Parallel groups<br> open <br> Italy </td> </tr> <tr> <td> <a href="index.html"> Garcia, 1997 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> accelerated t-PA 90 min (15 mg IV bolus followed by an infusion of 0.75 mg/kg over 30min not to exceed 50mg, and then 0.5 mg/kg over the next 60min not to exceed 35mg for a total maximun of 100mg) </td> <td> patients with anterior AMI </td> <td> follow-up 30 d<br> n=95/94<br> Parallel groups<br> open <br> Spain </td> </tr> <tr> <td> <a href="index.html"> GUSTO 2B, 1997 </a> <br> </td> <td> primary PTCA<br>  <i>versus</i> <br> accelerated t-PA 90 min (15 mg IV bolus followed by an infusion of 0.75 mg/kg over 30min not to exceed 50mg, and then 0.5 mg/kg over the next 60min not to exceed 35mg for a total maximun of 100mg) </td> <td> patients within 12 hours of acute myocardial infarction (with ST-segment elevation on the electrocardiogram) </td> <td> follow-up 30 d<br> n=573/565<br> factorial design<br> open <br> USA, Europe, Australia </td> </tr> <tr> <td> <a href="index.html"> TAMI 1 pilot, 1987 </a> <br> </td> <td> Angioplasty within 120 min (after rtPA)<br>  <i>versus</i> <br> defered CA (7-10 days) and angioplasty if indicated </td> <td> patients with acute myocardial infarction. </td> <td> follow-up in hospital<br> n=99/98<br> parallel group<br> open <br> USA </td> </tr> <tr> <td> <a href="index.html"> ECSG, 1988 </a> <br> </td> <td> angioplasty as soon as possible (after rtPA)<br>  <i>versus</i> <br> non-invasive strategy without immediate CA and PTCA </td> <td> patients with acute myocardial infarction within 5 h after onset of symptoms </td> <td> follow-up 1 y<br> n=183/184<br> parallel group<br> open <br> Europe </td> </tr> <tr> <td> <a href="index.html"> SWIFT, 1991 </a> <br> </td> <td> CA 72h with a view to PTCA or CABG<br>  <i>versus</i> <br> elective angioplasty (only if required by clinical indication) </td> <td> patients presenting with clinical and electrocardiographic features of acute myocardial infarction up to three hours after the onset of major symptoms </td> <td> follow-up 1 y<br> n=397/403<br> Parallel groups<br> Open <br> UK </td> </tr> <tr> <td> <a href="index.html"> SIAM, 1992 </a> <br> </td> <td> CA with CABG/PTCA 14-48 hours<br>  <i>versus</i> <br> no CA within the first 21days unless evidence of ischemia </td> <td> patients treated by thrombolysis for AMI </td> <td> follow-up <3 years<br> n=158/166<br> Parallel groups<br> Open <br> Europe </td> </tr> <tr> <td> <a href="index.html"> TIMI 2, 1989 </a> <br> </td> <td> CA 18 to 48 hrs<br>  <i>versus</i> <br> no CA unless spontaneous or exercise induced ischemia </td> <td> patients treated with intravenous recombinant tissue plasminogen activator (rt-PA) within four hours of the onset of chest pain thought to be caused by myocardial infarction </td> <td> follow-up 6 we<br> n=1636/1626<br> Factorial plan<br> Open <br> United states </td> </tr> <tr> <td> <a href="index.html"> Guerci, 1987 </a> <br> </td> <td> PTCA at 4 day <br>  <i>versus</i> <br> no PTCA during the 10 days study period </td> <td> patients candidate to PTCA determined at the 1st day CA </td> <td> follow-up 10 days<br> n=42/43<br> Factorial plan<br> <br> United states </td> </tr> <tr> <td> <a href="index.html"> Van den Brand, 1991 </a> <br> </td> <td> CA at 2-5 days, PTCA if suitable lesion <br>  <i>versus</i> <br> CA at 2-5 days but no PTCA </td> <td> suitable lesion </td> <td> follow-up 3 mo<br> n=113/104<br> Parallel groups<br> NA <br> Europe </td> </tr> <tr> <td> <a href="index.html"> TOPS, 1992 </a> <br> </td> <td> PTCA to be performed 4-14 days after MI<br>  <i>versus</i> <br> conservative management, no PTCA </td> <td> patients with residual stenoses after thrombolytic treatment of myocardial infarction </td> <td> follow-up 12 months<br> n=42/45<br> Parallel groups<br> <br> </td> </tr> <tr> <td> <a href="index.html"> Jaksch, 1998 </a> <br> </td> <td> Various stent <br>  <i>versus</i> <br> </td> <td> </td> <td> follow-up 6 months<br> n=231/231<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> GRAMI (Rodriguez), 1998 </a> <br> </td> <td> balloon angioplasty followed electively with Gianturco Roubin II stents<br>  <i>versus</i> <br> conventional balloon angioplasty </td> <td> patients with acute myocardial infarction within 24 hours after onset </td> <td> follow-up 12 months<br> n=52/52<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> Zwolle 5 (Suryapranata), 1998 </a> <br> </td> <td> Stent Palmaz-Schatz<br>  <i>versus</i> <br> balloon angioplasty </td> <td> Patients with acute myocardial infarction </td> <td> follow-up 12 months<br> n=112/115<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> stent-PAMI (Grines), 1999 </a> <br> </td> <td> angioplasty with Stent Heparin-coated<br>  <i>versus</i> <br> angioplasty alone </td> <td> patients with acute myocardial infarction and with vessels suitable for stenting </td> <td> follow-up 12 months<br> n=452/448<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PASTA (Saito), 1999 </a> <br> </td> <td> Stent Palmaz-Schatz<br>  <i>versus</i> <br> primary balloon angioplasty </td> <td> patients with AMI within 12 hr from onset </td> <td> follow-up 12 months<br> n=67/70<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PRISAM (Kawashima), 1999 </a> <br> </td> <td> Stent Palmaz-Schatz <br>  <i>versus</i> <br> </td> <td> </td> <td> follow-up 6 months<br> n=110/112<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> STENTIM-2 (Maillard), 2000 </a> <br> </td> <td> systematic stenting with Stent Wiktor<br>  <i>versus</i> <br> conventional balloon angioplasty </td> <td> patients with AMI <12 h from symptom onset, with an occluded native coronary artery </td> <td> follow-up 12 months<br> n=101/110<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PSSAAMI (Scheller), 2001 </a> <br> </td> <td> Stent Wiktor GX<br>  <i>versus</i> <br> primary angioplasty </td> <td> patients within 24 hours after the onset of acute myocardial infarction </td> <td> follow-up 24 months<br> n=44/44<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PASSION, 2006 </a> <br> ISRCTN65027270 </td> <td> Taxus Express2<br>  <i>versus</i> <br> Express2 or Liberté </td> <td> Myocardial Infarction with ST-Segment Elevation </td> <td> follow-up 12 months (5y)<br> n=310/309<br> Parallel groups<br> open <br> The Netherlands </td> </tr> <tr> <td> <a href="index.html"> HAAMU-STENT, 2006 </a> <br> </td> <td> Taxus Express<br>  <i>versus</i> <br> Bare-metal-stent </td> <td> AMI - STEMI patients undergoing PCI </td> <td> follow-up 12 months<br> n=70/75<br> Parallel groups<br> open <br> Finland </td> </tr> <tr> <td> <a href="index.html"> TYPHOON, 2006 </a> <br> NCT00232830 </td> <td> Cypher or CypherSelect<br>  <i>versus</i> <br> any commerciallyavailable uncoated stent </td> <td> AMI </td> <td> follow-up 12 months<br> n=356/359<br> Parallel groups<br> open <br> Worldwide (15 countries) </td> </tr> <tr> <td> <a href="index.html"> SESAMI, 2007 </a> <br> NCT00288210 </td> <td> Cypher<br>  <i>versus</i> <br> BX stent, Cordis </td> <td> AMI </td> <td> follow-up 12 months<br> n=160/160<br> Parallel groups<br> open <br> Italy </td> </tr> <tr> <td> <a href="index.html"> MISSION, 2008 </a> <br> ISRCTN62825862 </td> <td> Cypher<br>  <i>versus</i> <br> Vision </td> <td> primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (<9h) </td> <td> follow-up 12 months<br> n=158/152<br> Parallel groups<br> single-blind <br> the Netherlands </td> </tr> <tr> <td> <a href="index.html"> PROSIT, 2006 </a> <br> </td> <td> SES Cordis<br>  <i>versus</i> <br> PES Boston Scientific </td> <td> AMI or persistent ischaemia 12-24h </td> <td> follow-up 1 year<br> n=154/154<br> Parallel groups<br> open <br> Korea </td> </tr> <tr> <td> <a href="index.html"> Di Lorenzo et al., 2005 </a> <br> </td> <td> sirolimus<br>  <i>versus</i> <br> paclitaxel </td> <td> ST-segment elevation myocardial infarction </td> <td> follow-up <br> n=90/90<br> Parallel groups<br> open <br> NA </td> </tr> <tr> <td> <a href="index.html"> ZEST AMI (vs PES), 2009 </a> <br> NCT00422565 </td> <td> zotarolimus-eluting stent (Endeavor) <br>  <i>versus</i> <br> paclitaxel-eluting stent (Taxus Liberté) </td> <td> Acute Myocardial Infarction Patients (STEMI)requiring primary angioplasty with symptom onset <= 12 hours </td> <td> follow-up 1 year (mean)<br> n=108/110<br> <br> open <br> Korea </td> </tr> <tr> <td> <a href="index.html"> Díaz de la Llera, 2007 </a> <br> </td> <td> sirolimus-eluting stents<br>  <i>versus</i> <br> uncoated stents </td> <td> primary percutaneous coronary intervention for acute myocardial infarction with ST-segment elevation </td> <td> follow-up 1y<br> n=60/54<br> Parallel groups<br> open <br> Spain </td> </tr> <tr> <td> <a href="index.html"> DANAMI-2, 1997 </a> <br> </td> <td> angioplasty<br>  <i>versus</i> <br> accelerated treatment with intravenous alteplase </td> <td> patients who received thrombolytic treatment for a first acute myocardial infarction and with inducible myocardial ischemia (either symptomatic angina pectoris presenting spontaneously > 36 hours after admission or during a predischarge exercise test or ST changes during exercise compatible with ischemia) </td> <td> follow-up 2.4y<br> n=-9/-9<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> CARESS, 2008 </a> <br> </td> <td> immediate transfer for PCI after half-dose reteplase, abciximab, heparin, and aspirin<br>  <i>versus</i> <br> half-dose reteplase, abciximab, heparin, and aspirin, transfer for PCI only if they had persistent ST elevation at 90 minutes (rescue PCI) </td> <td> STEMI patients under 75 years old within 12 hours of symptom onset who had been admitted to hospitals without PCI facilities </td> <td> follow-up 30 days<br> n=-9/-9<br> <br> open <br> France, Italy, and Poland </td> </tr> <tr> <td> <a href="index.html"> CAPITAL AMI, 2005 </a> <br> </td> <td> full-dose tenecteplase (TNK) plus PCI<br>  <i>versus</i> <br> thrombolysis alone </td> <td> high-risk MI patients within six hours of symptom onset </td> <td> follow-up 6 months<br> n=86/84<br> Parallel groups<br> open <br> US </td> </tr> <tr> <td> <a href="index.html"> DEDICATION, 2008 </a> <br> NCT00192868 </td> <td> DES currently used with or without distal protection <br>  <i>versus</i> <br> BMS with or without distal protection </td> <td> patients referred within 12 hours from symptom onset of an ST-elevation myocardial infarction </td> <td> follow-up 8 mo (15 mo, 3y)<br> n=313/313<br> Factorial plan<br> open <br> Denmark. </td> </tr> <tr> <td> <a href="index.html"> HORIZONS-AMI Stent, 2008 </a> <br> </td> <td> paclitaxel-eluting stents (Taxus)<br>  <i>versus</i> <br> BMS (Express) </td> <td> ST-elevation myocardial infarction </td> <td> follow-up 1 year<br> n=2257/749<br> Factorial plan<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> ZEST AMI (vs SES), 2009 </a> <br> NCT00422565 </td> <td> zotarolimus-eluting stent (Endeavor) <br>  <i>versus</i> <br> sirolimus-eluting stents (Cypher) </td> <td> Acute Myocardial Infarction Patients (STEMI)requiring primary angioplasty with symptom onset <= 12 hours </td> <td> follow-up 1 year (mean)<br> n=108/110<br> Parallel groups<br> open <br> Korea </td> </tr> <tr> <td> <a href="index.html"> WEST, 2006 </a> <br> </td> <td> TNK and mandatory invasive study <= 24 h, including rescue PCI for reperfusion failure<br>  <i>versus</i> <br> tenecteplase (TNK) and usual care </td> <td> STEMI patients (> 4 mm ST-elevation/deviation) within 6 h of symptom onse </td> <td> follow-up 30 days<br> n=104/100<br> Parallel groups<br> <br> Canada </td> </tr> <tr> <td> <a href="index.html"> CAPITAL AMI, 2005 </a> <br> </td> <td> TNK-facilitated angioplasty<br>  <i>versus</i> <br> TNK alone </td> <td> patients with high-risk ST-segment elevation myocardial infarction </td> <td> follow-up 6 months<br> n=86/84<br> Parallel groups<br> <br> </td> </tr> <tr> <td> <a href="index.html"> GRACIA-1, 2004 </a> <br> </td> <td> angiography and intervention if indicated within 24 h of thrombolysis<br>  <i>versus</i> <br> ischaemia-guided conservative approach </td> <td> patients with thrombolysed STEMI (with recombinant tissue plasminogen activator) </td> <td> follow-up 12 months<br> n=248/251<br> Parallel groups<br> <br> </td> </tr> <tr> <td> <a href="index.html"> SIAM III, 2002 </a> <br> </td> <td> immediate stenting after thrombolysis<br>  <i>versus</i> <br> conservative treatment </td> <td> patients receiving thrombolysis in AMI (<12 h) </td> <td> follow-up 6 months<br> n=82/81<br> Parallel groups<br> <br> Germany </td> </tr> <tr> <td> <a href="index.html"> PRAGUE, 2000 </a> <br> </td> <td> thrombolysis during immediate transportation for coronary angioplasty<br>  <i>versus</i> <br> thrombolysis in a community hospital </td> <td> patients with acute ST elevation myocardial infarction presenting to community hospitals </td> <td> follow-up 12 months<br> n=100/99<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> TIMI II-A (defered), 0 </a> <br> </td> <td> delayed invasive strategy, deferred angiography and PTCA for 18-48 hours<br>  <i>versus</i> <br> conservative approach </td> <td> </td> <td> follow-up <br> n=194/197<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> TAMI-5 (Califf), 1991 </a> <br> </td> <td> immediate catheterization with angioplasty for failed thrombolysis (90min after rtPA/urokinase)<br>  <i>versus</i> <br> deferred predischarge catheterization on days 5-10, no PTCA planned </td> <td> patient with acute myocardial infarction </td> <td> follow-up <br> n=287/288<br> Factorial plan<br> <br> </td> </tr> <tr> <td> <a href="index.html"> Ellis, 1994 </a> <br> </td> <td> balloon angioplasty supplemented by further thrombolytic therapy as needed<br>  <i>versus</i> <br> conservative therapy </td> <td> patients with first anterior wall infarction treated with any accepted intravenous thrombolytic regimen and angiographically demonstrated to have an occluded infarct vessel within 8 hours of chest pain onset </td> <td> follow-up <br> n=78/73<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> Vermeer, 1999 </a> <br> </td> <td> alteplase followed by transfer to the PTCA centre and (if indicated) rescue PTCA<br>  <i>versus</i> <br> thrombolytic treatment with alteplase </td> <td> patients with acute myocardial infarction initially admitted to a hospital without PTCA facilities </td> <td> follow-up 42 days<br> n=-9/-9<br> Parallel groups<br> <br> </td> </tr> <tr> <td> <a href="index.html"> Erbel, 1989 </a> <br> </td> <td> combined intravenous and intracoronary streptokinase with immediate coronary angioplasty<br>  <i>versus</i> <br> combined intravenous and intracoronary streptokinase without immediate coronary angioplasty </td> <td> patients with acute transmural myocardial infarction </td> <td> follow-up 3 years<br> n=103/103<br> Parallel groups<br> <br> </td> </tr> <tr> <td> <a href="index.html"> MERLIN (Sutton), 2004 </a> <br> </td> <td> emergency coronary angiography with rescue PCI<br>  <i>versus</i> <br> conservative treatment </td> <td> patients with STEMI and failed fibrinolysis </td> <td> follow-up 30 days<br> n=-9/-9<br> Parallel groups<br> <br> </td> </tr> <tr> <td> <a href="index.html"> SWISS-SMASH, 1999 </a> <br> </td> <td> emergency angiography, followed immediately by revascularization when indicated<br>  <i>versus</i> <br> initial medical management </td> <td> Patients with acute myocardial infarction and early shock </td> <td> follow-up 30 days (1y)<br> n=32/23<br> Parallel groups<br> open <br> Europe </td> </tr> <tr> <td> <a href="index.html"> FRESCO, 1998 </a> <br> </td> <td> elective stenting after successful primary PTCA<br>  <i>versus</i> <br> no further intervention after successful primary PTCA </td> <td> patient with successful primary PTCA </td> <td> follow-up 12 months<br> n=75/75<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> CADILLAC abciximab., 2002 </a> <br> </td> <td> stenting plus abciximab therapy<br>  <i>versus</i> <br> PTCA plus abciximab therapy </td> <td> patients with acute myocardial infarction </td> <td> follow-up 12 months<br> n=524/528<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> CADILLAC (no abciximab), 2002 </a> <br> </td> <td> stenting alone with the MultiLink stent<br>  <i>versus</i> <br> PTCA alone </td> <td> patients with acute myocardial infarction </td> <td> follow-up 12 months<br> n=512/518<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> ZWOLLE 6, 2005 </a> <br> </td> <td> stenting<br>  <i>versus</i> <br> balloon angioplasty </td> <td> unselected patients with STEMI </td> <td> follow-up 12 months<br> n=785/763<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> STOPAMI 3, 2004 </a> <br> </td> <td> coronary artery stenting<br>  <i>versus</i> <br> PTCA </td> <td> patients with AMI ineligible for thrombolysis (lack of ST-segment elevation on the electrocardiogram, late presentation >12 h after symptom onset, and contraindications to thrombolysis) </td> <td> follow-up 6 months<br> n=305/306<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> TIMI 2A, 1988 </a> <br> </td> <td> CA within 120 min of the start of the rtPA infusion. PTCA whether the artery is open or closed<br>  <i>versus</i> <br> CA within 18-48hrs. PTCA only if artery open (TIMI 2 or 3) </td> <td> patient thrombolyzed for a AMI </td> <td> follow-up 21 days<br> n=195/194<br> parallel group<br> open <br> USA </td> </tr> <tr> <td> <a href="index.html"> Belenkie, 1991 </a> <br> </td> <td> immediate PTCA<br>  <i>versus</i> <br> delayed PTCA (18-38h) </td> <td> patients with a patent infarct-related artery after thrombolytic therapy suitable for angioplasty </td> <td> follow-up 4 months<br> n=50/39<br> parallel group<br> open <br> Canada </td> </tr> <tr> <td> <a href="index.html"> Topol, 1987 </a> <br> </td> <td> immediate PTCA<br>  <i>versus</i> <br> no PTCA </td> <td> patients with evolving transmural myocardial infarction </td> <td> follow-up in hospital<br> n=15/13<br> parallel group<br> open <br> USA </td> </tr> <tr> <td> <a href="index.html"> TAMI 6, 1992 </a> <br> </td> <td> PTCA 6-24h after rtPA<br>  <i>versus</i> <br> no PTCA planned </td> <td> </td> <td> follow-up <br> n=34/37<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> Barbash, 1990 </a> <br> </td> <td> PTCA>72h after rtPA if stenosis>70%<br>  <i>versus</i> <br> PTCA>72h after rtPA if stenosis>50% and ischemia </td> <td> </td> <td> follow-up <br> n=97/104<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> MAASTRICHT (Vermeer), 1999 </a> <br> </td> <td> Transfer for primary PTCA<br>  <i>versus</i> <br> immediate thrombolysis with tPA </td> <td> patients with acute myocardial infarction initially admitted to a hospital without PTCA facilities </td> <td> follow-up <br> n=75/75<br> <br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PRAGUE-1, 2000 </a> <br> </td> <td> immediate transportation for primary angioplasty without pre-treatment with thrombolysis<br>  <i>versus</i> <br> immediate thrombolysis with streptokinase </td> <td> patients with acute myocardial infarction, presenting within 6 h of symptom onset at community hospitals without a catheterization laboratory </td> <td> follow-up 30 days<br> n=101/99<br> <br> open <br> </td> </tr> <tr> <td> <a href="index.html"> AIR-PAMI, 2002 </a> <br> </td> <td> Transfer for Primary Angioplasty<br>  <i>versus</i> <br> immediate thrombolysis (various thrombolytic) </td> <td> Patients with high-risk AMI (age >70 years, anterior MI, Killip class II/III, heart rate >100 beats/min or systolic BP <100 mm Hg), eligible for thrombolytic therapy </td> <td> follow-up <br> n=71/66<br> <br> open <br> </td> </tr> <tr> <td> <a href="index.html"> CAPTIM, 2002 </a> <br> </td> <td> Transfer for Primary Angioplasty<br>  <i>versus</i> <br> prehospital fibrinolysis with accelerated alteplase </td> <td> patients within 6 h of acute myocardial infarction with ST-segment elevation, initially managed by mobile emergency-care units </td> <td> follow-up <br> n=421/419<br> <br> open <br> </td> </tr> <tr> <td> <a href="index.html"> DANAMI-2, 2003 </a> <br> </td> <td> Transfer for Primary Angioplasty<br>  <i>versus</i> <br> immediate thrombolysis with tPA (accelared infusion) </td> <td> patients with myocardial infarction with ST-segment elevation </td> <td> follow-up 30 days<br> n=567/562<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PRAGUE-2, 2003 </a> <br> </td> <td> immediate transport for primary percutaneous coronary intervention<br>  <i>versus</i> <br> immediate thrombolysis with streptokinase </td> <td> patients with acute ST elevation myocardial infarction presenting within <12 h to the nearest community hospital without a catheter laboratory </td> <td> follow-up 30 days<br> n=429/421<br> <br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PRAGUE-1 (thrombolysis+PTCA), 2000 </a> <br> </td> <td> thrombolytic therapy during transportation to angioplasty<br>  <i>versus</i> <br> immediate thrombolysis with streptokinase </td> <td> patients with acute myocardial infarction, presenting within 6 h of symptom onset at community hospitals without a catheterization laboratory </td> <td> follow-up 30 days<br> n=100/99<br> Parallel groups<br> open <br> Czech Republic </td> </tr> <tr> <td> <a href="index.html"> Zijlstra , 1993 </a> <br> </td> <td> immediate coronary angioplasty (without previous thrombolytic therapy)<br>  <i>versus</i> <br> intravenous streptokinase </td> <td> patients with acute myocardial infarction </td> <td> follow-up <br> n=70/72<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> Akhras, 1997 </a> <br> </td> <td> primary angioplasty<br>  <i>versus</i> <br> streptokinase </td> <td> patient within 12hr from onset of AMI </td> <td> follow-up <br> n=42/45<br> Parallel groups<br> open <br> Saudi Arabia </td> </tr> <tr> <td> <a href="index.html"> O'Neill, 1986 </a> <br> </td> <td> coronary angioplasty<br>  <i>versus</i> <br> intracoronary streptokinase </td> <td> patients within 12 hours of their first symptoms of acute myocardial infarction </td> <td> follow-up <br> n=-9/-9<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> AIR-PAMI , 2002 </a> <br> </td> <td> Transfer for Primary Angioplasty<br>  <i>versus</i> <br> immediate thrombolysis (various thrombolytic) </td> <td> Patients with high-risk AMI (age >70 years, anterior MI, Killip class II/III, heart rate >100 beats/min or systolic BP <100 mm Hg), eligible for thrombolytic therapy </td> <td> follow-up <br> n=71/66<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> DANAMI-2 , 2003 </a> <br> </td> <td> Transfer for Primary Angioplasty<br>  <i>versus</i> <br> immediate thrombolysis with tPA (accelared infusion) </td> <td> patients with myocardial infarction with ST-segment elevation </td> <td> follow-up 30 days<br> n=567/562<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PRAGUE-2 , 2003 </a> <br> </td> <td> immediate transport for primary percutaneous coronary intervention<br>  <i>versus</i> <br> immediate thrombolysis with streptokinase </td> <td> patients with acute ST elevation myocardial infarction presenting within <12 h to the nearest community hospital without a catheter laboratory </td> <td> follow-up 30 days<br> n=429/421<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> STAT, 2001 </a> <br> </td> <td> primary stenting<br>  <i>versus</i> <br> accelerated t-PA </td> <td> patients with acute ST-elevation myocardial infarction </td> <td> follow-up 6 months<br> n=62/61<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> STOPAMI 1, 2000 </a> <br> </td> <td> stent plus abciximab<br>  <i>versus</i> <br> intravenous alteplase </td> <td> patients with acute myocardial infarction </td> <td> follow-up 6 months<br> n=71/69<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> C-PORT, 2002 </a> <br> </td> <td> primary PCI without on-site cardiac surgery<br>  <i>versus</i> <br> accelerated tissue plasminogen activator </td> <td> thrombolytic-eligible patients with acute MI of less than 12 hours' duration associated with ST-segment elevation </td> <td> follow-up 6 months<br> n=225/226<br> Parallel groups<br> open <br> USA </td> </tr> <tr> <td> <a href="index.html"> STOPAMI 2, 2002 </a> <br> </td> <td> stenting combined with abciximab<br>  <i>versus</i> <br> fibrinolysis by alteplase combined with abciximab </td> <td> patients with acute myocardial infarction within 12 h of onset of symptoms </td> <td> follow-up <br> n=81/81<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> senior PAMI, 2005 </a> <br> NCT00136929 </td> <td> primary percutaneous coronary intervention<br>  <i>versus</i> <br> intravenous thrombolytic therapy </td> <td> elderly (age >= 70 years) patients with acute myocardial infarction </td> <td> follow-up 30 days<br> n=252/229<br> Parallel groups<br> Open <br> </td> </tr> <tr> <td> <a href="index.html"> NORDISTEMI, 2009 </a> <br> NCT00161005 </td> <td> transfer for immediate coronary angiography and intervention<br>  <i>versus</i> <br> concervative strategy </td> <td> patients with STEMI of less than 6 hours of duration and more than 90 minutes expected time delay to PCI </td> <td> follow-up 1y<br> n=134/132<br> Parallel groups<br> open <br> Norway </td> </tr> <tr> <td> <a href="index.html"> TRIANA, 2009 </a> <br> NCT00257309 </td> <td> Tenecteplase + UFH (+/- clopidogrel)<br>  <i>versus</i> <br> Primary angioplasty </td> <td> >=75 years old with ST-segment elevation or LBBB AMI <6 hours of evolution without contraindications for thrombolytic therapy </td> <td> follow-up 30 days (12 months)<br> n=132/134<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PASEO, 2009 </a> <br> </td> <td> paclitaxel-eluting stents and sirolimus-eluting stents<br>  <i>versus</i> <br> bare metal stent </td> <td> patients with ST-elevation myocardial infarction within 12 hours from symptom onset </td> <td> follow-up 4.3 years<br> n=180/90<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> Juwana, 2009 </a> <br> ISRCTN90526229 </td> <td> sirolimus coated Cypher stent<br>  <i>versus</i> <br> paclitaxel coated Taxus stent </td> <td> patients with STEMI undergoing primary PCI </td> <td> follow-up 9 months (12 months)<br> n=196/201<br> Parallel groups<br> open <br> The Netherlands </td> </tr> <tr> <td> <a href="index.html"> DEBATER (SES vs BMS), 2009 </a> <br> </td> <td> sirolimus-eluting stents<br>  <i>versus</i> <br> bare-metal stents </td> <td> patients undergoing PCI for STEMI withon 12 hours </td> <td> follow-up 1 y<br> n=424/446<br> Factorial plan<br> <br> </td> </tr> <tr> <td> <a href="index.html"> TRANSFER-AMI, 2008 </a> <br> NCT00164190 </td> <td> pharmacoinvasive strategy (transfer for PCI within six hours of fibrinolysis)<br>  <i>versus</i> <br> standard treatment after fibrinolysis (rescue PCI for failed reperfusion, with elective PCI encouraged for successfully reperfused patients after 24 hours) </td> <td> patients with high-risk STEMI </td> <td> follow-up 30 days<br> n=-9/-9<br> Parallel groups<br> open <br> </td> </tr> </table> <h2>References</h2> <p> <b>Zwolle, 1994 : </b> de Boer MJ, Hoorntje JC, Ottervanger JP, Reiffers S, Suryapranata H, Zijlstra FImmediate coronary angioplasty versus intravenous streptokinase in acute myocardial infarction: left ventricular ejection fraction, hospital mortality and reinfarction. <i>J Am Coll Cardiol 1994;23:1004-8</i> [PMID 8144761] </p> <p> <b>Ribeiro, 1993 : </b> Ribeiro EE, Silva LA, Carneiro R, D'Oliveira LG, Gasquez A, Amino JG, Tavares JR, Petrizzo A, Torossian S, Duprat Filho RRandomized trial of direct coronary angioplasty versus intravenous streptokinase in acute myocardial infarction. <i>J Am Coll Cardiol 1993;22:376-80</i> [PMID 8335807] </p> <p> <b>Grinfeld, 1996 : </b> Grinfeld L et al.abstract <i>JACC 1996;27:222A</i> [PMID ] </p> <p> <b>Zijlstra, 1997 : </b> Zijlstra F, Beukema WP, van 't Hof AW, Liem A, Reiffers S, Hoorntje JC, Suryapranata H, de Boer MJRandomized comparison of primary coronary angioplasty with thrombolytic therapy in low risk patients with acute myocardial infarction. <i>J Am Coll Cardiol 1997;29:908-12</i> [PMID 9120174] </p> <p> <b>DeWood, 1989 : </b> DeWood MA, Fisher MJ for the spokane Heart Research Group <i>Circulation 1989; 80(suppl 2):II418</i> [PMID ] </p> <p> <b>PAMI, 1993 : </b> Grines CL, Browne KF, Marco J, Rothbaum D, Stone GW, O'Keefe J, Overlie P, Donohue B, Chelliah N, Timmis GCA comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group. <i>N Engl J Med 1993;328:673-9</i> [PMID 8433725] </p> <p> <b>Gibbons, 1993 : </b> Gibbons RJ, Holmes DR, Reeder GS, Bailey KR, Hopfenspirger MR, Gersh BJImmediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. The Mayo Coronary Care Unit and Catheterization Laboratory Groups. <i>N Engl J Med 1993;328:685-91</i> [PMID 8433727] </p> <p> <b>Ribichini, 1996 : </b> <i> JACC 1996; 211A</i> [PMID 0] </p> <p> <b>Garcia, 1997 : </b> García E, Elízaga J, Pérez-Castellano N, Serrano JA, Soriano J, Abeytua M, Botas J, Rubio R, López de Sá E, López-Sendón JL, Delcán JLPrimary angioplasty versus systemic thrombolysis in anterior myocardial infarction. <i>J Am Coll Cardiol 1999;33:605-11</i> [PMID 10080458] </p> <p> <b>GUSTO 2B, 1997 : </b> A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. The Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy Investigators. <i>N Engl J Med 1997;336:1621-8</i> [PMID 9173270] </p> <p> <b>TAMI 1 pilot, 1987 : </b> Topol EJ, Califf RM, George BS, Kereiakes DJ, Abbottsmith CW, Candela RJ, Lee KL, Pitt B, Stack RS, O'Neill WWA randomized trial of immediate versus delayed elective angioplasty after intravenous tissue plasminogen activator in acute myocardial infarction. <i>N Engl J Med 1987 Sep 3;317:581-8</i> [PMID 2956516] </p> <p> <b>ECSG, 1988 : </b> Simoons ML, Arnold AE, Betriu A, de Bono DP, Col J, Dougherty FC, von Essen R, Lambertz H, Lubsen J, Meier B, et al,Thrombolysis with tissue plasminogen activator in acute myocardial infarction: no additional benefit from immediate percutaneous coronary angioplasty. <i>Lancet 1988; 1:197-203</i> [PMID 2893037] </p> <p> <b>ECSG, 1988 : </b> Arnold AE, Simoons ML, Van de Werf F, de Bono DP, Lubsen J, Tijssen JG, Serruys PW, Verstraete MRecombinant tissue-type plasminogen activator and immediate angioplasty in acute myocardial infarction. One-year follow-up. The European Cooperative Study Group. <i>Circulation 1992 Jul;86:111-20</i> [PMID 1617763] </p> <p> <b>SWIFT, 1991 : </b> ,SWIFT trial of delayed elective intervention v conservative treatment after thrombolysis with anistreplase in acute myocardial infarction. SWIFT (Should We Intervene Following Thrombolysis?) Trial Study Group. <i>BMJ 1991; 302:555-60</i> [PMID 2021717] </p> <p> <b>SIAM, 1992 : </b> <i>JACC 1992 19:239A(abstract)</i> [PMID 0] </p> <p> <b>TIMI 2, 1989 : </b> ,Comparison of invasive and conservative strategies after treatment with intravenous tissue plasminogen activator in acute myocardial infarction. Results of the thrombolysis in myocardial infarction (TIMI) phase II trial. The TIMI Study Group. <i>N Engl J Med 1989; 320:618-27</i> [PMID 2563896] </p> <p> <b>Guerci, 1987 : </b> Guerci AD, Gerstenblith G, Brinker JA, Chandra NC, Gottlieb SO, Bahr RD, Weiss JL, Shapiro EP, Flaherty JT, Bush DE, et al,A randomized trial of intravenous tissue plasminogen activator for acute myocardial infarction with subsequent randomization to elective coronary angioplasty. <i>N Engl J Med 1987; 317:1613-8</i> [PMID 2960897] </p> <p> <b>Van den Brand, 1991 : </b> <i>Eur Heart J 1991;I296 (abstract)</i> [PMID 0] </p> <p> <b>TOPS, 1992 : </b> Ellis SG, Mooney MR, George BS, da Silva EE, Talley JD, Flanagan WH, Topol EJRandomized trial of late elective angioplasty versus conservative management for patients with residual stenoses after thrombolytic treatment of myocardial infarction. Treatment of Post-Thrombolytic Stenoses (TOPS) Study Group. <i>Circulation 1992 Nov;86:1400-6</i> [PMID 1423952] </p> <p> <b>Jaksch, 1998 : </b> Jaksch R, Niehus R, Knobloch W, Schiele T. s_cc=PTCA versus stenting in acute myocardial infarctione/pj <i>Eur Heart J. 1998;19:1341x-xbitm</i> [PMID ] </p> <p> <b>GRAMI (Rodriguez), 1998 : </b> Rodríguez A, Bernardi V, Fernández M, Mauvecín C, Ayala F, Santaera O, Martínez J, Mele E, Roubin GS, Palacios I, Ambrose JAIn-hospital and late results of coronary stents versus conventional balloon angioplasty in acute myocardial infarction (GRAMI trial). Gianturco-Roubin in Acute Myocardial Infarction. <i>Am J Cardiol 1998;81:1286-91</i> [PMID 9631964] </p> <p> <b>Zwolle 5 (Suryapranata), 1998 : </b> Suryapranata H, van 't Hof AW, Hoorntje JC, de Boer MJ, Zijlstra FRandomized comparison of coronary stenting with balloon angioplasty in selected patients with acute myocardial infarction. <i>Circulation 1998;97:2502-5</i> [PMID 9657469] </p> <p> <b>stent-PAMI (Grines), 1999 : </b> Grines CL, Cox DA, Stone GW, Garcia E, Mattos LA, Giambartolomei A, Brodie BR, Madonna O, Eijgelshoven M, Lansky AJ, O'Neill WW, Morice MCCoronary angioplasty with or without stent implantation for acute myocardial infarction. Stent Primary Angioplasty in Myocardial Infarction Study Group. <i>N Engl J Med 1999;341:1949-56</i> [PMID 10607811] </p> <p> <b>PASTA (Saito), 1999 : </b> Saito S, Hosokawa G, Tanaka S, Nakamura SPrimary stent implantation is superior to balloon angioplasty in acute myocardial infarction: final results of the primary angioplasty versus stent implantation in acute myocardial infarction (PASTA) trial. PASTA Trial Investigators. <i>Catheter Cardiovasc Interv 1999;48:262-8</i> [PMID 10525224] </p> <p> <b>PRISAM (Kawashima), 1999 : </b> Kawashima A, Ueda K, Nishida Y, et al.agQuantitative angiographic analysis of restenosis of primary stenting using Wiktor stent for acute myocardial infarction: results from a multicenter randomized PRISAM study.6 <i>Circulation. 1999;100(suppl 1):I856..ag</i> [PMID ] </p> <p> <b>STENTIM-2 (Maillard), 2000 : </b> Maillard L, Hamon M, Khalife K, Steg PG, Beygui F, Guermonprez JL, Spaulding CM, Boulenc JM, Lipiecki J, Lafont A, Brunel P, Grollier G, Koning R, Coste P, Favereau X, Lancelin B, Van Belle E, Serruys P, Monassier JP, Raynaud PA comparison of systematic stenting and conventional balloon angioplasty during primary percutaneous transluminal coronary angioplasty for acute myocardial infarction. STENTIM-2 Investigators. <i>J Am Coll Cardiol 2000;35:1729-36</i> [PMID 10841218] </p> <p> <b>PSSAAMI (Scheller), 2001 : </b> Scheller B, Hennen B, Severin-Kneib S, Ozbek C, Schieffer H, Markwirth TLong-term follow-up of a randomized study of primary stenting versus angioplasty in acute myocardial infarction. <i>Am J Med 2001;110:1-6</i> [PMID 11152857] </p> <p> <b>Stone (CADILLAC), 2002 : </b> Stone GW, Grines CL, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Carroll JD, Rutherford BD, Lansky AJComparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction. <i>N Engl J Med 2002;346:957-66</i> [PMID 11919304] </p> <p> <b>PASSION, 2006 : </b> Laarman GJ, Suttorp MJ, Dirksen MT, van Heerebeek L, Kiemeneij F, Slagboom T, van der Wieken LR, Tijssen JG, Rensing BJ, Patterson MPaclitaxel-eluting versus uncoated stents in primary percutaneous coronary intervention. <i>N Engl J Med 2006;355:1105-13</i> [PMID 16971717] </p> <p> <b>PASSION, 2006 : </b> Dirksen MT, Vink MA, Suttorp MJ, Tijssen JG, Patterson MS, Slagboom T, Kiemeneij F, Laarman GJ <i>EuroIntervention 2008 May;4:64-70</i> [PMID 19112781] </p> <p> <b>HAAMU-STENT, 2006 : </b> Tierala I, Syvaenne M, Kupari MRandomised comparison of apaclitaxel-eluting and a bare metal stent in STEMI-PCI. TheHAAMU-STENT-study <i>Annual Scientifi c Meeting of theTranscatheter Cardiovascular Therapeutics; Washington, DC;Oct 2227, 2006. Abstract 178.</i> [PMID ] </p> <p> <b>TYPHOON, 2006 : </b> Spaulding C, Henry P, Teiger E, Beatt K, Bramucci E, Carri D, Slama MS, Merkely B, Erglis A, Margheri M, Varenne O, Cebrian A, Stoll HP, Snead DB, Bode CSirolimus-eluting versus uncoated stents in acute myocardial infarction. <i>N Engl J Med 2006;355:1093-104</i> [PMID 16971716] </p> <p> <b>SESAMI, 2007 : </b> Menichelli M, Parma A, Pucci E, Fiorilli R, De Felice F, Nazzaro M, Giulivi A, Alborino D, Azzellino A, Violini RRandomized trial of Sirolimus-Eluting Stent Versus Bare-Metal Stent in Acute Myocardial Infarction (SESAMI). <i>J Am Coll Cardiol 2007;49:1924-30</i> [PMID 17498576] </p> <p> <b>SESAMI, 2007 : </b> Violini R, Musto C, De Felice F, Nazzaro MS, Cifarelli A, Petitti T, Fiorilli RMaintenance of Long-Term Clinical Benefit With Sirolimus-Eluting Stents in Patients With ST-Segment Elevation Myocardial Infarction 3-Year Results of the SESAMI (Sirolimus-Eluting Stent Versus Bare-Metal Stent In Acute Myocardial Infarction) Trial. <i>J Am Coll Cardiol 2010 Feb 23;55:810-814</i> [PMID 20170821] 10.1016/j.jacc.2009.09.046 </p> <p> <b>MISSION, 2008 : </b> van der Hoeven BL, Liem S, Jukema JW, et al.Prospectiverandomised trial to evaluate the effi cacy and safety of drug-elutingstents versus barem-metal stents for the treatment of acutemyocardial infarction (the MISSION! intervention study) <i>AnnualScientifi c Meeting of the American Heart Association. Chicago, IL,USA; Nov 1215, 2006.</i> [PMID ] </p> <p> <b>MISSION, 2008 : </b> van der Hoeven BL, Liem SS, Jukema JW, Suraphakdee N, Putter H, Dijkstra J, Atsma DE, Bootsma M, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Schalij MJSirolimus-eluting stents versus bare-metal stents in patients with ST-segment elevation myocardial infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study. <i>J Am Coll Cardiol 2008 Feb 12;51:618-26</i> [PMID 18261680] </p> <p> <b>PROSIT, 2006 : </b> Lee JH, Kim HS, Lee SW, et al.Prospective randomized trial of asirolimus eluting versus a paclitaxel eluting stent for the treatmentof acute ST-elevation myocardial infarction <i>Annual Scientifi cMeeting of the American College of Cardiology; Atlanta, GA, USA;March 1114, 2006.</i> [PMID ] </p> <p> <b>PROSIT, 2006 : </b> Kornowski RDrug-eluting stents in ST elevation myocardial infarction: In light of the PROSIT trial. <i>Catheter Cardiovasc Interv 2008 Jul 1;72:33-5</i> [PMID 18561153] </p> <p> <b>PROSIT, 2006 : </b> Lee JH, Kim HS, Lee SW, Park JH, Choi SW, Jeong JO, Cho Y, Lee N, Rhee KS, Ko JK, Seong IWProspective randomized comparison of sirolimus- versus paclitaxel-eluting stents for the treatment of acute ST-elevation myocardial infarction: pROSIT trial. <i>Catheter Cardiovasc Interv 2008 Jul 1;72:25-32</i> [PMID 18412270] </p> <p> <b>Di Lorenzo et al., 2005 : </b> Di Lorenzo E, Varricchio A, Lanzillo T, et al.Paclitaxel and sirolimusstent implantation in patients with acute myocardial infarction (abstr) <i>Circulation 2005;112:U538</i> [PMID ] </p> <p> <b>ZEST AMI (vs PES), 2009 : </b> Lee CW, Park DW, Lee SH, Kim YH, Hong MK, Kim JJ, Park SW, Yun SC, Seong IW, Lee JH, Lee NH, Cho YH, Cheong SS, Lim DS, Yang JY, Lee SG, Kim KS, Yoon J, Jeong MH, Seung KB, Hong TJ, Park SJComparison of the efficacy and safety of zotarolimus-, sirolimus-, and paclitaxel-eluting stents in patients with ST-elevation myocardial infarction. <i>Am J Cardiol 2009;104:1370-6</i> [PMID 19892052] </p> <p> <b>Díaz de la Llera, 2007 : </b> Daz de la Llera LS, Ballesteros S, Nevado J, Fernndez M, Villa M, Snchez A, Retegui G, Garca D, Martnez ASirolimus-eluting stents compared with standard stents in the treatment of patients with primary angioplasty. <i>Am Heart J 2007;154:164.e1-6</i> [PMID 17584571] </p> <p> <b>MULTISTRATEGY, 2008 : </b> Valgimigli M, Campo G, Percoco G, Bolognese L, Vassanelli C, Colangelo S, de Cesare N, Rodriguez AE, Ferrario M, Moreno R, Piva T, Sheiban I, Pasquetto G, Prati F, Nazzaro MS, Parrinello G, Ferrari RComparison of angioplasty with infusion of tirofiban or abciximab and with implantation of sirolimus-eluting or uncoated stents for acute myocardial infarction: the MULTISTRATEGY randomized trial. <i>JAMA 2008;299:1788-99</i> [PMID 18375998] </p> <p> <b>DANAMI-2, 1997 : </b> Fosbøl EL, Thune JJ, Kelbaeaek H, Andersen HR, Saunamääki K, Nielsen TT, Mortensen LS, Køøber LLong-term outcome of primary angioplasty compared with fibrinolysis across age groups: a Danish Multicenter Randomized Study on Fibrinolytic Therapy Versus Acute Coronary Angioplasty in Acute Myocardial Infarction (DANAMI-2) substudy. <i>Am Heart J 2008;156:391-6</i> [PMID 18657676] </p> <p> <b>DANAMI-2, 1997 : </b> Madsen JK, Grande P, Saunamäki K, Thayssen P, Kassis E, Eriksen U, Rasmussen K, Haunsø S, Nielsen TT, Haghfelt T, Fritz-Hansen P, Hjelms E, Paulsen PK, Alstrup P, Arendrup H, Niebuhr-Jørgensen U, Andersen LIDanish multicenter randomized study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction. <i>Circulation 1997 Aug 5;96:748-55</i> [PMID 9264478] </p> <p> <b>DANAMI-2, 1997 : </b> Madsen JK, Nielsen TT, Grande P, Eriksen UH, Saunamäki K, Thayssen P, Kassis E, Rasmussen K, Haunsø S, Haghfelt T, Fritz-Hansen P, Hjelms E, Paulsen PK, Alstrup P, Arendrup H, Niebuhr-Jørgensen U, Andersen LIRevascularization compared to medical treatment in patients with silent vs. symptomatic residual ischemia after thrombolyzed myocardial infarction--the DANAMI study. <i>Cardiology 2007;108:243-51</i> [PMID 17114878] </p> <p> <b>DANAMI-2, 1997 : </b> Andersen HR, Nielsen TT, Rasmussen K, Thuesen L, Kelbaek H, Thayssen P, Abildgaard U, Pedersen F, Madsen JK, Grande P, Villadsen AB, Krusell LR, Haghfelt T, Lomholt P, Husted SE, Vigholt E, Kjaergard HK, Mortensen LSA comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. <i>N Engl J Med 2003 Aug 21;349:733-42</i> [PMID 12930925] </p> <p> <b>DANAMI-2, 1997 : </b> Nielsen PH, Maeng M, Busk M, Mortensen LS, Kristensen SD, Nielsen TT, Andersen HRPrimary angioplasty versus fibrinolysis in acute myocardial infarction: long-term follow-up in the Danish acute myocardial infarction 2 trial. <i>Circulation 2010;121:1484-91</i> [PMID 20308618] 10.1161/CIRCULATIONAHA.109.873224 </p> <p> <b>TRANSFER-AMI, 2008 : </b> Cantor WJ, Fitchett D, Borgundvaag B, Heffernan M, Cohen EA, Morrison LJ, Ducas J, Langer A, Mehta S, Lazzam C, Schwartz B, Dzavik V, Goodman SGRationale and design of the Trial of Routine ANgioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI). <i>Am Heart J 2008;155:19-25</i> [PMID 18082484] </p> <p> <b>TRANSFER-AMI, 2008 : </b> Cantor WJ, Fitchett D, Borgundvaag B, Ducas J, Heffernan M, Cohen EA, Morrison LJ, Langer A, Dzavik V, Mehta SR, Lazzam C, Schwartz B, Casanova A, Goodman SGRoutine early angioplasty after fibrinolysis for acute myocardial infarction. <i>N Engl J Med 2009 Jun 25;360:2705-18</i> [PMID 19553646] </p> <p> <b>CARESS, 2008 : </b> Di Mario C, Dudek D, Piscione F, Mielecki W, Savonitto S, Murena E, Dimopoulos K, Manari A, Gaspardone A, Ochala A, Zmudka K, Bolognese L, Steg PG, Flather MImmediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial. <i>Lancet 2008;371:559-68</i> [PMID 18280326] </p> <p> <b>CARESS, 2008 : </b> Di Mario C, Bolognese L, Maillard L, Dudek D, Gambarati G, Manari A, Guiducci V, Patrizi G, Rusconi LC, Piovaccari G, Hibon AR, Belpomme V, Indolfi C, Olivari Z, Steffenino G, Zmudka K, Airoldi F, Panzarasa R, Flather M, Steg PGCombined Abciximab REteplase Stent Study in acute myocardial infarction (CARESS in AMI). <i>Am Heart J 2004;148:378-85</i> [PMID 15389222] </p> <p> <b>CAPITAL AMI, 2005 : </b> Le May MR, Wells GA, Labinaz M, Davies RF, Turek M, Leddy D, Maloney J, McKibbin T, Quinn B, Beanlands RS, Glover C, Marquis JF, O'Brien ER, Williams WL, Higginson LACombined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study). <i>J Am Coll Cardiol 2005 Aug 2;46:417-24</i> [PMID 16053952] </p> <p> <b>DEDICATION, 2008 : </b> Kelbaek H, Thuesen L, Helqvist S, Clemmensen P, Klvgaard L, Kaltoft A, Andersen B, Thuesen H, Engstrm T, Btker HE, Saunamki K, Krusell LR, Jrgensen E, Hansen HH, Christiansen EH, Ravkilde J, Kber L, Kofoed KF, Terkelsen CJ, Lassen JFDrug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial. <i>Circulation 2008 Sep 9;118:1155-62</i> [PMID 18725489] </p> <p> <b>DEDICATION, 2008 : </b> Kaltoft A, Kelbæk H, Thuesen L, Lassen JF, Clemmensen P, Kløvgaard L, Engstrøm T, Bøtker HE, Saunamäki K, Krusell LR, Jørgensen E, Tilsted HH, Christiansen EH, Ravkilde J, Køber L, Kofoed KF, Terkelsen CJ, Helqvist SLong-Term Outcome After Drug-Eluting Versus Bare-Metal Stent Implantation in Patients With ST-Segment Elevation Myocardial Infarction 3-Year Follow-Up of the Randomized DEDICATION (Drug Elution and Distal Protection in Acute Myocardial Infarction) Trial. <i>J Am Coll Cardiol 2010 Jun 14;:</i> [PMID 20688033] 10.1016/j.jacc.2010.05.009 </p> <p> <b>ZEST AMI (vs SES), 2009 : </b> Lee CW, Park DW, Lee SH, Kim YH, Hong MK, Kim JJ, Park SW, Yun SC, Seong IW, Lee JH, Lee NH, Cho YH, Cheong SS, Lim DS, Yang JY, Lee SG, Kim KS, Yoon J, Jeong MH, Seung KB, Hong TJ, Park SJComparison of the efficacy and safety of zotarolimus-, sirolimus-, and paclitaxel-eluting stents in patients with ST-elevation myocardial infarction. <i>Am J Cardiol 2009;104:1370-6</i> [PMID 19892052] </p> <p> <b>WEST, 2006 : </b> Armstrong PWA comparison of pharmacologic therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study. <i>Eur Heart J 2006;27:1530-8</i> [PMID 16757491] </p> <p> <b>CAPITAL AMI, 2005 : </b> Le May MR, Wells GA, Labinaz M, Davies RF, Turek M, Leddy D, Maloney J, McKibbin T, Quinn B, Beanlands RS, Glover C, Marquis JF, O'Brien ER, Williams WL, Higginson LACombined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study). <i>J Am Coll Cardiol 2005;46:417-24</i> [PMID 16053952] </p> <p> <b>GRACIA-1, 2004 : </b> Fernandez-Avilés F, Alonso JJ, Castro-Beiras A, Vázquez N, Blanco J, Alonso-Briales J, López-Mesa J, Fernández-Vazquez F, Calvo I, Martínez-Elbal L, San Román JA, Ramos BRoutine invasive strategy within 24 hours of thrombolysis versus ischaemia-guided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA-1): a randomised controlled trial. <i>Lancet 2004;364:1045-53</i> [PMID 15380963] </p> <p> <b>SIAM III, 2002 : </b> Scheller B, Hennen B, Hammer B, Walle J, Hofer C, Hilpert V, Winter H, Nickenig G, Böhm MBeneficial effects of immediate stenting after thrombolysis in acute myocardial infarction. <i>J Am Coll Cardiol 2003;42:634-41</i> [PMID 12932593] </p> <p> <b>PRAGUE, 2000 : </b> Widimský P, Groch L, Zelízko M, Aschermann M, Bednár F, Suryapranata HMulticentre randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory. The PRAGUE study. <i>Eur Heart J 2000;21:823-31</i> [PMID 10781354] </p> <p> <b>PRAGUE, 2000 : </b> Bednár F, Widimský P, Krupicka J, Groch L, Aschermann M, Zelízko MInterhospital transport for primary angioplasty improves the long-term outcome of acute myocardial infarction compared with immediate thrombolysis in the nearest hospital (one-year follow-up of the PRAGUE-1 study). <i>Can J Cardiol 2003;19:1133-7</i> [PMID 14532938] </p> <p> <b>TIMI II-A (defered), 0 : </b> Rogers WJ, Baim DS, Gore JM, Brown BG, Roberts R, Williams DO, Chesebro JH, Babb JD, Sheehan FH, Wackers FJComparison of immediate invasive, delayed invasive, and conservative strategies after tissue-type plasminogen activator. Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial. <i>Circulation 1990;81:1457-76</i> [PMID 2110033] </p> <p> <b>TAMI-5 (Califf), 1991 : </b> Califf RM, Topol EJ, Stack RS, Ellis SG, George BS, Kereiakes DJ, Samaha JK, Worley SJ, Anderson JL, Harrelson-Woodlief LEvaluation of combination thrombolytic therapy and timing of cardiac catheterization in acute myocardial infarction. Results of thrombolysis and angioplasty in myocardial infarction--phase 5 randomized trial. TAMI Study Group. <i>Circulation 1991;83:1543-56</i> [PMID 1902405] </p> <p> <b>Ellis, 1994 : </b> Ellis SG, da Silva ER, Heyndrickx G, Talley JD, Cernigliaro C, Steg G, Spaulding C, Nobuyoshi M, Erbel R, Vassanelli CRandomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial infarction. <i>Circulation 1994;90:2280-4</i> [PMID 7955184] </p> <p> <b>Vermeer, 1999 : </b> Vermeer F, Oude Ophuis AJ, vd Berg EJ, Brunninkhuis LG, Werter CJ, Boehmer AG, Lousberg AH, Dassen WR, Bär FWProspective randomised comparison between thrombolysis, rescue PTCA, and primary PTCA in patients with extensive myocardial infarction admitted to a hospital without PTCA facilities: a safety and feasibility study. <i>Heart 1999;82:426-31</i> [PMID 10490554] </p> <p> <b>Erbel, 1989 : </b> Erbel R, Pop T, Diefenbach C, Meyer JLong-term results of thrombolytic therapy with and without percutaneous transluminal coronary angioplasty. <i>J Am Coll Cardiol 1989;14:276-85; discussion 286-8</i> [PMID 2526830] </p> <p> <b>MERLIN (Sutton), 2004 : </b> Sutton AG, Campbell PG, Graham R, Price DJ, Gray JC, Grech ED, Hall JA, Harcombe AA, Wright RA, Smith RH, Murphy JJ, Shyam-Sundar A, Stewart MJ, Davies A, Linker NJ, de Belder MAA randomized trial of rescue angioplasty versus a conservative approach for failed fibrinolysis in ST-segment elevation myocardial infarction: the Middlesbrough Early Revascularization to Limit INfarction (MERLIN) trial. <i>J Am Coll Cardiol 2004;44:287-96</i> [PMID 15261920] </p> <p> <b>LIMI (Vermeer), 1999 : </b> Vermeer F, Oude Ophuis AJ, vd Berg EJ, Brunninkhuis LG, Werter CJ, Boehmer AG, Lousberg AH, Dassen WR, Bär FWProspective randomised comparison between thrombolysis, rescue PTCA, and primary PTCA in patients with extensive myocardial infarction admitted to a hospital without PTCA facilities: a safety and feasibility study. <i>Heart 1999;82:426-31</i> [PMID 10490554] </p> <p> <b>SWISS-SMASH, 1999 : </b> Urban P, Stauffer JC, Bleed D, Khatchatrian N, Amann W, Bertel O, van den Brand M, Danchin N, Kaufmann U, Meier B, Machecourt J, Pfisterer MA randomized evaluation of early revascularization to treat shock complicating acute myocardial infarction. The (Swiss) Multicenter Trial of Angioplasty for Shock-(S)MASH. <i>Eur Heart J 1999 Jul;20:1030-8</i> [PMID 10383377] </p> <p> <b>FRESCO, 1998 : </b> Antoniucci D, Santoro GM, Bolognese L, Valenti R, Trapani M, Fazzini PFA clinical trial comparing primary stenting of the infarct-related artery with optimal primary angioplasty for acute myocardial infarction: results from the Florence Randomized Elective Stenting in Acute Coronary Occlusions (FRESCO) trial. <i>J Am Coll Cardiol 1998;31:1234-9</i> [PMID 9581713] </p> <p> <b>CADILLAC abciximab., 2002 : </b> Stone GW, Grines CL, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Carroll JD, Rutherford BD, Lansky AJComparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction. <i>N Engl J Med 2002;346:957-66</i> [PMID 11919304] </p> <p> <b>CADILLAC (no abciximab), 2002 : </b> Stone GW, Grines CL, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Carroll JD, Rutherford BD, Lansky AJComparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction. <i>N Engl J Med 2002;346:957-66</i> [PMID 11919304] </p> <p> <b>ZWOLLE 6, 2005 : </b> Suryapranata H, De Luca G, van 't Hof AW, Ottervanger JP, Hoorntje JC, Dambrink JH, Gosselink AT, Zijlstra F, de Boer MJIs routine stenting for acute myocardial infarction superior to balloon angioplasty? A randomised comparison in a large cohort of unselected patients. <i>Heart 2005;91:641-5</i> [PMID 15831652] </p> <p> <b>ZWOLLE 6, 2005 : </b> De Luca G, Suryapranata H, van't Hof AW, Ottervanger JP, Hoorntje JC, Dambrink JH, Gosselink AT, de Boer MJRoutine stenting vs. balloon angioplasty in ST-segment elevation myocardial infarction due to proximal left anterior descending coronary artery occlusion. <i>J Cardiovasc Med (Hagerstown) 2009 Jan;10:22-6</i> [PMID 19145115] </p> <p> <b>STOPAMI 3, 2004 : </b> Kastrati A, Mehilli J, Nekolla S, Bollwein H, Martinoff S, Pache J, Schühlen H, Seyfarth M, Gawaz M, Neumann FJ, Dirschinger J, Schwaiger M, Schömig AA randomized trial comparing myocardial salvage achieved by coronary stenting versus balloon angioplasty in patients with acute myocardial infarction considered ineligible for reperfusion therapy. <i>J Am Coll Cardiol 2004;43:734-41</i> [PMID 14998609] </p> <p> <b>TIMI 2A, 1988 : </b> Immediate vs delayed catheterization and angioplasty following thrombolytic therapy for acute myocardial infarction. TIMI II A results. The TIMI Research Group. <i>JAMA 1988 Nov 18;260:2849-58</i> [PMID 2972848] </p> <p> <b>Belenkie, 1991 : </b> Belenkie I, Knudtson ML, Roth DL, Hansen JL, Traboulsi M, Hall CA, Manyari D, Filipchuck NG, Schnurr LP, Rosenal TWRelation between flow grade after thrombolytic therapy and the effect of angioplasty on left ventricular function: a prospective randomized trial. <i>Am Heart J 1991 Feb;121:407-16</i> [PMID 1990744] </p> <p> <b>Topol, 1987 : </b> Topol EJ, O'Neill WW, Langburd AB, Walton JA Jr, Bourdillon PD, Bates ER, Grines CL, Schork AM, Kline E, Pitt BA randomized, placebo-controlled trial of intravenous recombinant tissue-type plasminogen activator and emergency coronary angioplasty in patients with acute myocardial infarction. <i>Circulation 1987 Feb;75:420-8</i> [PMID 2948735] </p> <p> <b>TAMI 6, 1992 : </b> Topol EJ, Califf RM, Vandormael M, Grines CL, George BS, Sanz ML, Wall T, O'Brien M, Schwaiger M, Aguirre FVA randomized trial of late reperfusion therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction-6 Study Group. <i>Circulation 1992 Jun;85:2090-9</i> [PMID 1591828] </p> <p> <b>Barbash, 1990 : </b> Barbash GI, Roth A, Hod H, Modan M, Miller HI, Rath S, Zahav YH, Keren G, Motro M, Shachar ARandomized controlled trial of late in-hospital angiography and angioplasty versus conservative management after treatment with recombinant tissue-type plasminogen activator in acute myocardial infarction. <i>Am J Cardiol 1990 Sep 1;66:538-45</i> [PMID 2118299] </p> <p> <b>MAASTRICHT (Vermeer), 1999 : </b> Vermeer F, Oude Ophuis AJ, vd Berg EJ, Brunninkhuis LG, Werter CJ, Boehmer AG, Lousberg AH, Dassen WR, Bär FWProspective randomised comparison between thrombolysis, rescue PTCA, and primary PTCA in patients with extensive myocardial infarction admitted to a hospital without PTCA facilities: a safety and feasibility study. <i>Heart 1999;82:426-31</i> [PMID 10490554] </p> <p> <b>PRAGUE-1, 2000 : </b> Widimský P, Groch L, Zelízko M, Aschermann M, Bednár F, Suryapranata HMulticentre randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory. The PRAGUE study. <i>Eur Heart J 2000;21:823-31</i> [PMID 10781354] </p> <p> <b>AIR-PAMI, 2002 : </b> Grines CL, Westerhausen DR Jr, Grines LL, Hanlon JT, Logemann TL, Niemela M, Weaver WD, Graham M, Boura J, O'Neill WW, Balestrini CA randomized trial of transfer for primary angioplasty versus on-site thrombolysis in patients with high-risk myocardial infarction: the Air Primary Angioplasty in Myocardial Infarction study. <i>J Am Coll Cardiol 2002;39:1713-9</i> [PMID 12039480] </p> <p> <b>CAPTIM, 2002 : </b> Bonnefoy E, Lapostolle F, Leizorovicz A, Steg G, McFadden EP, Dubien PY, Cattan S, Boullenger E, Machecourt J, Lacroute JM, Cassagnes J, Dissait F, Touboul PPrimary angioplasty versus prehospital fibrinolysis in acute myocardial infarction: a randomised study. <i>Lancet 2002;360:825-9</i> [PMID 12243916] </p> <p> <b>DANAMI-2, 2003 : </b> Fosbøl EL, Thune JJ, Kelbaek H, Andersen HR, Saunamäki K, Nielsen TT, Mortensen LS, Køber LLong-term outcome of primary angioplasty compared with fibrinolysis across age groups: a Danish Multicenter Randomized Study on Fibrinolytic Therapy Versus Acute Coronary Angioplasty in Acute Myocardial Infarction (DANAMI-2) substudy. <i>Am Heart J 2008 Aug;156:391-6</i> [PMID 18657676] </p> <p> <b>DANAMI-2, 2003 : </b> Madsen JK, Grande P, Saunamäki K, Thayssen P, Kassis E, Eriksen U, Rasmussen K, Haunsø S, Nielsen TT, Haghfelt T, Fritz-Hansen P, Hjelms E, Paulsen PK, Alstrup P, Arendrup H, Niebuhr-Jørgensen U, Andersen LIDanish multicenter randomized study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction. <i>Circulation 1997 Aug 5;96:748-55</i> [PMID 9264478] </p> <p> <b>DANAMI-2, 2003 : </b> Madsen JK, Nielsen TT, Grande P, Eriksen UH, Saunamäki K, Thayssen P, Kassis E, Rasmussen K, Haunsø S, Haghfelt T, Fritz-Hansen P, Hjelms E, Paulsen PK, Alstrup P, Arendrup H, Niebuhr-Jørgensen U, Andersen LIRevascularization compared to medical treatment in patients with silent vs. symptomatic residual ischemia after thrombolyzed myocardial infarction--the DANAMI study. <i>Cardiology 2007;108:243-51</i> [PMID 17114878] </p> <p> <b>DANAMI-2, 2003 : </b> Andersen HR, Nielsen TT, Rasmussen K, Thuesen L, Kelbaek H, Thayssen P, Abildgaard U, Pedersen F, Madsen JK, Grande P, Villadsen AB, Krusell LR, Haghfelt T, Lomholt P, Husted SE, Vigholt E, Kjaergard HK, Mortensen LSA comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. <i>N Engl J Med 2003 Aug 21;349:733-42</i> [PMID 12930925] </p> <p> <b>PRAGUE-2, 2003 : </b> Widimský P, Budesínský T, Vorác D, Groch L, Zelízko M, Aschermann M, Branny M, St'ásek J, Formánek PLong distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of the randomized national multicentre trial--PRAGUE-2. <i>Eur Heart J 2003;24:94-104</i> [PMID 12559941] </p> <p> <b>PRAGUE-1 (thrombolysis+PTCA), 2000 : </b> Widimský P, Groch L, Zelízko M, Aschermann M, Bednár F, Suryapranata HMulticentre randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory. The PRAGUE study. <i>Eur Heart J 2000;21:823-31</i> [PMID 10781354] </p> <p> <b>Zijlstra , 1993 : </b> Zijlstra F, de Boer MJ, Hoorntje JC, Reiffers S, Reiber JH, Suryapranata HA comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. <i>N Engl J Med 1993;328:680-4</i> [PMID 8433726] </p> <p> <b>Akhras, 1997 : </b> Akhras F, AbuOusa A, Swann G, Duncan H, ChamsiPasha H, Jabbad H.Primary coronary angioplasty or intravenous thrombolysis for patients with acute myocardial infarction? acute and late follow-up results in a new cardiac unit [abstract4 <i>J Am Coll Cardiol. 1997;29(suppl 1):A235</i> [PMID ] </p> <p> <b>Kedev, 1997 : </b> Kedev S, Petrovski B, Kotevski V, Antov S, Sokolov I, Jovanova S.Primary coronary angioplasty versus intravenous streptokinase in acute myocardial infarction [abstract] <i>J Am Coll Cardiol. 1997;29(suppl A):92542</i> [PMID ] </p> <p> <b>O'Neill, 1986 : </b> O'Neill W, Timmis GC, Bourdillon PD, Lai P, Ganghadarhan V, Walton J Jr, Ramos R, Laufer N, Gordon S, Schork MAA prospective randomized clinical trial of intracoronary streptokinase versus coronary angioplasty for acute myocardial infarction. <i>N Engl J Med 1986;314:812-8</i> [PMID 2936956] </p> <p> <b>AIR-PAMI , 2002 : </b> Grines CL, Westerhausen DR Jr, Grines LL, Hanlon JT, Logemann TL, Niemela M, Weaver WD, Graham M, Boura J, O'Neill WW, Balestrini CA randomized trial of transfer for primary angioplasty versus on-site thrombolysis in patients with high-risk myocardial infarction: the Air Primary Angioplasty in Myocardial Infarction study. <i>J Am Coll Cardiol 2002;39:1713-9</i> [PMID 12039480] </p> <p> <b>DANAMI-2 , 2003 : </b> Fosbøl EL, Thune JJ, Kelbaek H, Andersen HR, Saunamäki K, Nielsen TT, Mortensen LS, Køber LLong-term outcome of primary angioplasty compared with fibrinolysis across age groups: a Danish Multicenter Randomized Study on Fibrinolytic Therapy Versus Acute Coronary Angioplasty in Acute Myocardial Infarction (DANAMI-2) substudy. <i>Am Heart J 2008 Aug;156:391-6</i> [PMID 18657676] </p> <p> <b>DANAMI-2 , 2003 : </b> Madsen JK, Grande P, Saunamäki K, Thayssen P, Kassis E, Eriksen U, Rasmussen K, Haunsø S, Nielsen TT, Haghfelt T, Fritz-Hansen P, Hjelms E, Paulsen PK, Alstrup P, Arendrup H, Niebuhr-Jørgensen U, Andersen LIDanish multicenter randomized study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction. <i>Circulation 1997 Aug 5;96:748-55</i> [PMID 9264478] </p> <p> <b>DANAMI-2 , 2003 : </b> Madsen JK, Nielsen TT, Grande P, Eriksen UH, Saunamäki K, Thayssen P, Kassis E, Rasmussen K, Haunsø S, Haghfelt T, Fritz-Hansen P, Hjelms E, Paulsen PK, Alstrup P, Arendrup H, Niebuhr-Jørgensen U, Andersen LIRevascularization compared to medical treatment in patients with silent vs. symptomatic residual ischemia after thrombolyzed myocardial infarction--the DANAMI study. <i>Cardiology 2007;108:243-51</i> [PMID 17114878] </p> <p> <b>DANAMI-2 , 2003 : </b> Andersen HR, Nielsen TT, Rasmussen K, Thuesen L, Kelbaek H, Thayssen P, Abildgaard U, Pedersen F, Madsen JK, Grande P, Villadsen AB, Krusell LR, Haghfelt T, Lomholt P, Husted SE, Vigholt E, Kjaergard HK, Mortensen LSA comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. <i>N Engl J Med 2003 Aug 21;349:733-42</i> [PMID 12930925] </p> <p> <b>PRAGUE-2 , 2003 : </b> Widimský P, Budesínský T, Vorác D, Groch L, Zelízko M, Aschermann M, Branny M, St'ásek J, Formánek PLong distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of the randomized national multicentre trial--PRAGUE-2. <i>Eur Heart J 2003;24:94-104</i> [PMID 12559941] </p> <p> <b>PRAGUE-2 , 2003 : </b> Widimský P, Budesínský T, Vorác D, Groch L, Zelízko M, Aschermann M, Branny M, St'ásek J, Formánek PLong distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of the randomized national multicentre trial--PRAGUE-2. <i>Eur Heart J 2003;24:94-104</i> [PMID 12559941] </p> <p> <b>STAT, 2001 : </b> Le May MR, Labinaz M, Davies RF, Marquis JF, Laramée LA, O'Brien ER, Williams WL, Beanlands RS, Nichol G, Higginson LAStenting versus thrombolysis in acute myocardial infarction trial (STAT). <i>J Am Coll Cardiol 2001;37:985-91</i> [PMID 11263625] </p> <p> <b>STOPAMI 1, 2000 : </b> Schömig A, Kastrati A, Dirschinger J, Mehilli J, Schricke U, Pache J, Martinoff S, Neumann FJ, Schwaiger MCoronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators. <i>N Engl J Med 2000;343:385-91</i> [PMID 10933737] </p> <p> <b>C-PORT, 2002 : </b> Aversano T, Aversano LT, Passamani E, Knatterud GL, Terrin ML, Williams DO, Forman SAThrombolytic therapy vs primary percutaneous coronary intervention for myocardial infarction in patients presenting to hospitals without on-site cardiac surgery: a randomized controlled trial. <i>JAMA 2002;287:1943-51</i> [PMID 11960536] </p> <p> <b>STOPAMI 2, 2002 : </b> Kastrati A, Mehilli J, Dirschinger J, Schricke U, Neverve J, Pache J, Martinoff S, Neumann FJ, Nekolla S, Blasini R, Seyfarth M, Schwaiger M, Schömig AMyocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction: a randomised trial. <i>Lancet 2002;359:920-5</i> [PMID 11918909] </p> <p> <b>TRIANA, 2009 : </b> Clauw et alThe efficacy and safety of milnacpran in the treatment of fibromyalgia <i>2007, poster 716</i> [PMID ] </p> <p> <b>TRIANA, 2009 : </b> Bueno H, Betriu A, Heras M, Alonso JJ, Cequier A, García EJ, López-Sendón JL, Macaya C, Hernández-Antolín RPrimary angioplasty vs. fibrinolysis in very old patients with acute myocardial infarction: TRIANA (TRatamiento del Infarto Agudo de miocardio eN Ancianos) randomized trial and pooled analysis with previous studies. <i>Eur Heart J 2010;:</i> [PMID 20971744] 10.1093/eurheartj/ehq375 </p> <p> <b>PASEO, 2009 : </b> Di Lorenzo E, De Luca G, Sauro R, Varricchio A, Capasso M, Lanzillo T, Manganelli F, Mariello C, Siano F, Pagliuca MR, Stanco G, Rosato GThe PASEO (PaclitAxel or Sirolimus-Eluting Stent Versus Bare Metal Stent in Primary Angioplasty) Randomized Trial. <i>JACC Cardiovasc Interv 2009 Jun;2:515-23</i> [PMID 19539255] </p> <p> <b>PASEO, 2009 : </b> Di Lorenzo E, Sauro R, Varricchio A, Carbone G, Cortese G, Capasso M, Lanzillo T, Manganelli F, Mariello C, Siano F, Pagliuca MR, Stanco G, Rosato G, De Luca GLong-Term outcome of drug-eluting stents compared with bare metal stents in ST-segment elevation myocardial infarction: results of the paclitaxel- or sirolimus-eluting stent versus bare metal stent in Primary Angioplasty (PASEO) Randomized Trial. <i>Circulation 2009;120:964-72</i> [PMID 19720939] </p> <p> <b>Juwana, 2009 : </b> Juwana YB, Suryapranata H, Ottervanger JP, De Luca G, van't Hof AW, Dambrink JH, de Boer MJ, Gosselink AT, Hoorntje JCComparison of rapamycin- and paclitaxel-eluting stents in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction. <i>Am J Cardiol 2009;104:205-9</i> [PMID 19576348] </p>