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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

diabetes - anti hypertensive agent - type1 and 2 diabetic patients with hypertension

hypertension - anti hypertensive agent - diabetic patients


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INSIGHT (diabetic subgroup), 2000 - Nifedipine vs coamilozide

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NORDIL (diabetic subgroup), 2000 - Diltiazem vs diuretic or beta-blocker

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See also:

  • All diabetes clinical trials
  • All hypertension clinical trials
  • All clinical trials of anti hypertensive agent
  • All clinical trials of Diltiazem
    		•  

    NORDIL (diabetic subgroup) study, 2000

    Facebook    pdf : Diltiazem - anti hypertensive agent for hypertension

    Treatments

    Studied treatment Diltiazem 180–360 mg diltiazem daily at step one
    In step two, an angiotensin-converting-enzyme (ACE) inhibitor was added, and in step three, a diuretic or alpha-blocker was added to the ACE inhibitor. Any other antihypertensive compound could be added as step four.
    Control treatment thiazide diuretic or a beta-blocker at step one
    in step two, the two were combined. In step three an ACE inhibitor or alpha-blocker was added. In step four, any other antihypertensive compound could be added except a calcium antagonist

    Patients

    Patients diabetic patients (subgroup), aged 50-74 years who had diastolic blood pressure of 100 mm Hg or more
    Baseline characteristics
    subgroup yes 

    Method and design

    Randomized effectives 351 / 376 (studied vs. control)
    Design Parallel groups
    Blinding open
    Follow-up duration 4.5 y
    Number of centre 1032
    Geographic area Norway, Sweden
    Hypothesis Superiority
    Primary endpoint CV events


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    cardiovascular event (fatal and non fatal)

    NA / 10881
         NA / 0
         1,01 [0,66;1,54]

    All cause death

    NA / 10881
         NA / 0
         1,07 [0,63;1,82]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.

    Meta-analysis of all similar trials:

    anti hypertensive agent in diabetes for type1 and 2 diabetic patients with hypertension

    anti hypertensive agent in hypertension for diabetic patients



    Reference(s)

    Trials register # NA
    • Hansson L, Hedner T, Lund-Johansen P, Kjeldsen SE, Lindholm LH, Syvertsen JO, Lanke J, de Faire U, Dahlöf B, Karlberg BE. Randomised trial of effects of calcium antagonists compared with diuretics and beta-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study.. Lancet 2000;356:359-65
      Pubmed | Hubmed | Fulltext

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