List Of Non Gamstop Casinos UKCasinos Not On GamstopNon Gamstop CasinosCasino Non Aams ItaliaNon Gamstop Casinos
Trial-Results center  
Clinical trial results database Feedback    Home

Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

diabetes - anti hypertensive agent - type1 and 2 diabetic patients with hypertension

hypertension - anti hypertensive agent - diabetic patients


Related trials

ACCOMPLISH (diabetic subgroup), 2010 - benazepril + amlodipine vs benazepril + hydrochlorothiazide

ACCORD blood pressure, 2010 - more intensive blood pressure lowering strategie vs less intensive blood pressure lowering strategie

AVOID, 2008 - aliskiren vs placebo

ABCD (N), 2002 - more intensive blood pressure lowering strategie vs less intensive blood pressure lowering strategie

ALLHAT (lisi vs chlor, diabetic subgroup), 2002 - lisinopril vs chlorthalidone

LIFE (diabetic subgroup), 2002 - losartan vs atenolol

ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002 - amlodipine vs chlorthalidone

IPDM, 2001 - irbesartan vs placebo

IDNT amlodipine, 2001 - amlodipine vs placebo

RENAAL, 2001 - losartan vs placebo

IDNT irbesartan, 2001 - Irbesartan vs placebo

IDNT (irbesartan vs amlodipine), 2001 - Irbesartan vs amlodipine

STOP-2 CCB (diabetic subgroup), 2000 - calcium-channel blocker vs diuretic or beta-blocker

INSIGHT (diabetic subgroup), 2000 - Nifedipine vs coamilozide

ABCD (H), 2000 - more intensive blood pressure lowering strategie vs less intensive blood pressure lowering strategie

NORDIL (diabetic subgroup), 2000 - Diltiazem vs diuretic or beta-blocker

STOP-2 (ACEI vs CCB) (diabetic subgroup), 2000 - ACE inhibitor vs CCB

HOPE (diabetic subgroup), 2000 - ACE inhibitor vs placebo

STOP-2 ACEI (diabetic subgroup), 2000 - ACE inhibitor vs diuretic or beta-blocker

CAPP (diabetic subgroup), 1999 - captopril vs diuretic or beta-blocker

Syst-Eur (diabetic subgroup), 1999 - nitrendipine vs placebo

ABCD, 1998 - nisoldipine vs enalapril

UKPDS 38, 1998 - captopril or atenolol vs control

UKPDS 39, 1998 - captopril vs atenolol

FACET, 1997 - amlodipine vs fosinopril



See also:

  • All diabetes clinical trials
  • All hypertension clinical trials
  • All clinical trials of anti hypertensive agent
  • All clinical trials of calcium-channel blocker
    		•  

    STOP-2 CCB (diabetic subgroup) study, 2000

    Facebook    pdf : calcium-channel blocker - anti hypertensive agent for hypertension

    Treatments

    Studied treatment Calcium-channel blocker
    felodipine 2·5 mg or isradipine 2·5 mg daily. if the target blood pressure (
    Control treatment diuretic or beta-blocker
    atenolol 50 mg, metoprolol 100 mg, pindolol 5 mg, or fixed-ratio hydrochlorothiazide 25 mg plus amiloride 2·5 mg daily. Patients on beta-blockers were given hydrochlorothiazide 25 mg plus amiloride 2·5 mg as additional treatment if the target blood pressure (

    Patients

    Patients diabetic (subgroup) elderly patients aged 70-84 years
    Inclusion criteria hypertension (blood pressure >=180 mm Hg systolic, >=105 mmHg diastolic, or both); aged 70–84 years; isolated systolic hypertension could be included
    Remarks Of all 6614 patients included in the trial, 719 had diabetes
    Baseline characteristics
    Glycosylated hemoglobin 7.6% 
    BP (systolic/diastolic) 195/96 mmHg 
    Female (%) 60% 
    Age 75.8 y 
    subgroup yes 
    hypertension (%) 100% 

    Method and design

    Randomized effectives 231 / 253 (studied vs. control)
    Design Parallel groups
    Blinding open with blind assessment
    Follow-up duration 5.03y
    Number of centre 312
    Geographic area Sweden
    Primary endpoint renal death
    Remarks


    Results



    Endpoints and data reported in the trial's publication(s)

    Endpoint Events (%) Relative Risk 95% CI
    Studied treat. Control treat.
    Cardiovascular mortality 33 / 231 (14,3%) 45 / 253 (17,8%) 0,80 [0,53;1,21]
    Fatal myocardial infarction 7 / 231 (3,0%) 9 / 253 (3,6%) 0,85 [0,32;2,25]
    Fatal stroke 8 / 231 (3,5%) 9 / 253 (3,6%) 0,97 [0,38;2,48]
    Sudden death 11 / 231 (4,8%) 12 / 253 (4,7%) 1,00 [0,45;2,23]
    Other cardiovascular mortality 7 / 231 (3,0%) 15 / 253 (5,9%) 0,51 [0,21;1,23]
    All myocardial infarction 32 / 231 (13,9%) 26 / 253 (10,3%) 1,35 [0,83;2,19]
    All stroke 29 / 231 (12,6%) 39 / 253 (15,4%) 0,81 [0,52;1,27]
    All major cardiovascular events 69 / 231 (29,9%) 82 / 253 (32,4%) 0,92 [0,71;1,20]
    Total mortality 50 / 231 (21,6%) 67 / 253 (26,5%) 0,82 [0,59;1,13]
    Atrial fibrillation 24 / 231 (10,4%) 26 / 253 (10,3%) 1,01 [0,60;1,71]
    Congestive heart failure 24 / 231 (10,4%) 29 / 253 (11,5%) 0,91 [0,54;1,51]

    Endpoints used by the meta-analysis and data retained for this trial

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    cardiovascular event (fatal and non fatal)

    NA / 719
         NA / 0
         0,91 [0,66;1,26]

    Cardiovascular death

    NA / 719
         NA / 0
         0,78 [0,50;1,22]

    All cause death

    NA / 719
         NA / 0
         0,79 [0,54;1,15]

    stroke (fatal and non fatal)

    NA / 719
         NA / 0
         0,80 [0,49;1,30]

    myocardial infarction (fatal and non fatal)

    NA / 719
         NA / 0
         classic 1,31 [0,78;2,20]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.

    Meta-analysis of all similar trials:

    anti hypertensive agent in diabetes for type1 and 2 diabetic patients with hypertension

    anti hypertensive agent in hypertension for diabetic patients



    Reference(s)

    Trials register # NA
    • Lindholm LH, Hansson L, Ekbom T, Dahlöf B, Lanke J, Linjer E, Scherstén B, Wester PO, Hedner T, de Faire U. Comparison of antihypertensive treatments in preventing cardiovascular events in elderly diabetic patients: results from the Swedish Trial in Old Patients with Hypertension-2. STOP Hypertension-2 Study Group.. J Hypertens 2000;18:1671-5
      Pubmed | Hubmed | Fulltext
    • Hansson L, Lindholm LH, Ekbom T, Dahlöf B, Lanke J, Scherstén B, Wester PO, Hedner T, de Faire U. Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study.. Lancet 1999;354:1751-6
      Pubmed | Hubmed | Fulltext

    (c) 2004-2010 TrialResults-center - All Rights Reserved

    Tweet this  |  notify a friend

    Digital discoveries