new version V2017

Bivalirudin antithrombotics
Description Results

Hirulog-1 Hirulog Angiomax      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

BAT (Bittl), 1995bivalirudinheparin Low risk of bias Suggesting
HERO, 1997bivalirudinheparin Exploratory Suggesting
PROTECT-TIMI 30, 2006bivalirudineptifibatide + heparin Exploratory - NCT00250471
ACUITY (biva alone vs hep+aGP2b3a), 2006bivalirudinheparin + GP2b3a inhibitorsSuggestingNCT00093158
ACUITY (biva+aGP2b3a vs hep+aGP2b3a), 2006bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsNegativeNCT00093158
ACUITY (sub groups PCI, bivalirudin +aGP2b3a) importé, 2007bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsNegative
ACUITY (sub groups PCI, bivalirudin alone) importé, 2007bivalirudinheparin + GP2b3a inhibitorsSuggesting

acute myocardial infarction

HERO, 1997bivalirudinheparin Exploratory Suggesting

percutaneous coronary intervention

ARMYDA BIVALVEbivalirudinUFH -
BAT (Bittl), 1995bivalirudinUFH Low risk of bias Suggesting
Kleiman, 2002bivalirudin + eptifibatideheparin + GP2b3a inhibitors Exploratory -
REPLACE-2, 2003bivalirudinheparin + GP2b3a inhibitors -
REPLACE-1, 2004bivalirudinUFH Exploratory Negative
ACUITY (Stone) (bivalirudin alone), 2006bivalirudinheparin + GP2b3a inhibitors Risk of bias - NCT00093158
HORIZONS-AMI (Stone), 2008bivalirudinheparin + GP2b3a inhibitors Risk of bias SuggestingNCT00433966
ISAR-REACT 3, 2008bivalirudinUFH Low risk of bias - NCT00262054
NAPLES (Tavano), 2009bivalirudinUFH plus tirofiban Risk of bias Suggesting
BRAVE-4 ongoing Prasugrel and BivalirudinClopidogrel and Heparin - NCT00976092



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