new version V2017

acute coronary syndrome
Description Results

     

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

anti-anginal drugs

ranolazine
MERLIN TIMI 36, 2007ranolazine placeboSuggestingNCT00099788

antithrombotics

apixaban
APPRAISE-1 (10mg od), 2009apixabanplacebo Exploratory Negative NCT00313300
APPRAISE-1 (2.5 mg bid), 2009apixabanplaceboNegativeNCT00313300
APPRAISE 2, 2011apixabanplacebo Low risk of bias Negative NCT00831441
APPRAISE japan ongoing apixabanplacebo Exploratory - NCT00852397
argatroban
ARGAMI-2, 1998Argatrobanheparin -
aspirin
VA-pilotaspirinplaceboNegative
ALDUSA-pilotaspirinplaceboNegative
VA-main, 1983aspirinplaceboSuggesting
Canadian (Aspirin + sulfinpyrazone), 1985aspirin + sulfinpyrazoneplaceboNegative
Canadian (Aspirin vs PBO), 1985aspirinplacebo -
Théroux, 1988aspirinplaceboSuggesting
ATACS-pilot, 1990aspirincontrolNegative
RISC, 1990aspirinplaceboSuggesting
atopaxar
LANCELOT ACSatopaxarplacebo Exploratory -
J-LANCELOT, 2010atopaxarplacebo Exploratory -
bivalirudin
BAT (Bittl), 1995bivalirudinheparin Low risk of bias Suggesting
HERO, 1997bivalirudinheparin Exploratory Suggesting
PROTECT-TIMI 30, 2006bivalirudineptifibatide + heparin Exploratory - NCT00250471
ACUITY (biva alone vs hep+aGP2b3a), 2006bivalirudinheparin + GP2b3a inhibitorsSuggestingNCT00093158
ACUITY (biva+aGP2b3a vs hep+aGP2b3a), 2006bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsNegativeNCT00093158
ACUITY (sub groups PCI, bivalirudin +aGP2b3a) importé, 2007bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsNegative
ACUITY (sub groups PCI, bivalirudin alone) importé, 2007bivalirudinheparin + GP2b3a inhibitorsSuggesting
clopidogrel
CURE, 2001clopidogrel + aspirinaspirinSuggesting
CURE (PCI sub study), 2001clopidogrelplacebo Exploratory -
CURRENT OASIS 7 (clopidogrel), 2010clopidogrel high-dose regimenclopidogrel standard-dose Low risk of bias Negative NCT00335452
coumadin
ASPECT-2 (coumadin vs aspirin), 2002coumadinaspirinSuggesting
ASPECT-2 (coumadin+asp vs asp), 2002coumadincontrol (on top of aspirin)Suggesting
dabigatran
REDEEM, 2009dabigatranplaceboNegativeNCT00621855
dalteparin
FRISC (long term), 1996dalteparinplacebo (on top of aspirin) Exploratory Suggesting
FRISC (short term), 1996dalteparinplacebo (on top of aspirin) Low risk of bias -
FRIC prolonged treatment phase (LWMH vs PBO), 1997dalteparinplacebo (on top of aspirin)Negative
FRIC (acute phase LMWH vs UFH), 1997dalteparinUFH (on top of aspirin) Exploratory Negative
dipyridamol
Prandoni, 1991aspirin + dipyridamolplaceboNegative
Efegatran
Klootwijk, 1999Efegatranheparin Exploratory -
enoxaparin
RESCUEenoxaparinunfractionated heparin - NCT00077818
ESSENCE, 1997enoxaparinUFH (on top of aspirin)Suggesting
TIMI 11 B (short term), 1998enoxaparinUFH (on top of aspirin)Suggesting
TIMI 11 B (long term), 1998enoxaparinUFH (on top of aspirin)Negative
EVET, 2005enoxaparintinzaparinSuggesting
SYNERGY, 2005enoxaparinUFH (on top of aspirin)Negative NCT00043784
INTERACT, 2006enoxaparinUFH (on top of aspirin)Suggesting
fondaparinux
PENTUA, 2004fondaparinuxenoxaparin -
OASIS 5, 2006fondaparinuxenoxaparin - NCT00139815
hirudin
HELVETICA (Serruys), 1995Hirudinheparin Low risk of bias -
TIMI 9B, 1996Hirudinheparin Risk of bias -
GUSTO IIB, 1996Hirudinheparin Risk of bias -
OASIS pilot, 1997Hirudinheparin Exploratory -
OASIS, 1997Hirudinheparin Risk of bias -
HIT-4, 1999Hirudinheparin Exploratory -
OASIS 2, 1999Hirudinheparin Low risk of bias -
inogatran
TRIM, 1997Inogatranheparin Exploratory -
nadroparin
FRAXIS (6days), 1998nadroparinUFH (on top of aspirin) Low risk of bias Negative
FRAXIS (14 days), 1998nadroparinUFH (on top of aspirin)Negative
otamixaban
SEPIA-ACS1 TIMI 42, 2009otamixabanunfractionated heparin Exploratory SuggestingNCT00317395
prasugrel
TRITON-TIMI 38, 2007prasugrelclopidogrel Low risk of bias Suggesting NCT00097591
TRILOGY ACS (overall population), 2012prasugrelclopidogrel Low risk of bias NegativeNCT00699998
ACAPULCO ongoing prasugrelclopidogrel -
rivaroxaban
ATLAS ACS-TIMI 46 (5mg), 2009rivaroxaban 5mgplaceboNegative NCT00402597
ATLAS ACS-TIMI 46 (2.5mg), 2009rivaroxaban 2.5mgplaceboNegativeNCT00402597
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011rivaroxaban 2.5mgplacebo Low risk of bias Suggesting NCT00809965
ATLAS ACS 2 - TIMI 51 (5mg), 2011rivaroxaban 5mgplaceboSuggesting NCT00809965
sulfinpyrazone
Canadian (sulfinpyrazone alone), 1985sulfinpyrazoneplacebo -
ticagrelor
DISPERSE-2 (90mg), 2007ticagrelorclopidogrel Exploratory Negative
PLATO, 2009ticagrelorclopidogrel Low risk of bias SuggestingNCT00391872
ticlopidine
Florida UAticlopidineplaceboNegative
STAI, 1990ticlopidinecontrolSuggesting
trapidil
ModenatrapidilplaceboSuggesting
triflusal
Plaza, 1993triflusalplaceboSuggesting
UFH
Theroux (heparin+ASP vs ASP), 1988UFHcontrol (on top of aspirin)Suggesting
Theroux (heparin+aspirin vs PBO), 1988UFH + aspirinplaceboSuggesting
Theroux (heparin vs PBO), 1988UFHplaceboSuggesting
Cohen (ATACS pilot) (heparin vs asp), 1990UFH, warfarinaspirinNegative
Cohen (ATACS pilot) (heparin+aspirin vs asp), 1990UFH, warfarincontrol (on top of aspirin)Negative
RISC (heparin+aspirin vs ASP), 1990UFHcontrol (on top of aspirin)Negative
RISC (heparin vs PBO), 1990UFHplaceboNegative
RISC (ASP+ heparin vs PBO), 1990UFH + aspirinplaceboSuggesting
ATACS (Cohen), 1994UFH, warfarincontrol (on top of aspirin)Negative
Holdright, 1994UFHcontrol (on top of aspirin)Negative
Gurfinkel (UFH+aspririn vs aspirin), 1995UFHplacebo (on top of aspirin)Negative
warfarin
ATACS (pilot study) warfarin vs aspirin, 1990warfarinaspirinNegative
ATACS (pilot study) (warfarin vs control), 1990warfarincontrol (on top of aspirin)Negative
ATACS, 1994warfarincontrol (on top of aspirin)Negative
CARS, 1997warfarincontrol (on top of aspirin)Negative
Williams, 1997warfarinplacebo (on top of aspirin)Negative
OASIS Pilot (phase 1), 1998warfarincontrol (on top of aspirin)Negative
OASIS Pilot (phase 2), 1998warfarincontrol (on top of aspirin)Negative
OASIS-2 Warfarin Substudy, 2001warfarincontrol (on top of aspirin)Negative
Huyhn, 2001warfarinplacebo (on top of aspirin)Negative
APRICOT-2, 2002warfarincontrol (on top of aspirin)Negative
CHAMP, 2002warfarincontrol (on top of aspirin)Negative
WARIS, 2002warfarincontrol (on top of aspirin)Suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Negative
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)Negative
ximelagatran
ESTEEM, 2003ximelagatranplacebo Exploratory -

calcium channel blockers

diltiazem
DRS, 1986diltiazemplacebo -
Göbel (Dutch study), 1995diltiazemplacebo -
nifedipine
HINT (nifedipine vs metoprolol), 1988nifedipinemetoprolol -

cholesterol lowering intervention

atorvastatin
MIRACL, 2001atorvastatinplaceboacute coronary syndrome Low risk of bias Suggesting
Colivicchi, 2002atorvastatinusual careacute coronary syndrome Exploratory Negative
PROVE IT - TIMI 22, 2004atorvastatinpravastatinacute coronary syndromeSuggesting
ESTABLISH, 2004atorvastatinusual careacute coronary syndrome Exploratory Negative
fluvastatin
LIPS (sub groups), 2002fluvastatinplaceboacute coronary syndrome Exploratory Negative
FLORIDA, 2002fluvastatinplaceboacute coronary syndrome Low risk of bias Negative
Czech trial ongoing fluvastatinplaceboacute coronary syndrome Exploratory - NCT00171275
pravastatin
LAMIL, 1997pravastatinplaceboacute coronary syndrome Exploratory Negative
RECIFE, 1999pravastatinplaceboacute coronary syndrome Exploratory Negative
L-CAD, 2000pravastatinusual careacute coronary syndrome Exploratory Suggesting
PAIS, 2001pravastatinplaceboacute coronary syndrome Exploratory Negative
PTT, 2002pravastatinusual careacute coronary syndrome Exploratory Suggesting
PACT, 2004pravastatinplaceboacute coronary syndrome Low risk of bias Suggesting
simvastatin
A to Z, 2004simvastatinplaceboacute coronary syndromeNegative

myocardial revascularization

anistreplase
UNASEM, 1992anistreplaseplacebo Exploratory -
t-pa
Gold, 1987t-PAplacebo Exploratory -
Topol, 1988t-PAplacebo Exploratory Negative
Nicklas, 1989t-PAplacebo Exploratory Negative
Williams, 1990t-PAplacebo Exploratory Negative
Ardissino, 1990t-PAplacebo Exploratory Negative
van der Brand, 1991t-PAplacebo Exploratory Negative
Freeman, 1992t-PAplacebo Low risk of bias Negative
charbonnier, 1992t-PAplacebo Exploratory -
TIMI 3A, 1993t-PAplacebo Exploratory -
TIMI 3B, 1995t-PAplacebo Low risk of bias -

nitrates

nitroglycerin
Karlberg, 1998placebo -
Doucet, 2000placebo -



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