Trial-Results center  
Clinical trial results database in Heart and vessels Feedback    Home

Related trials

ACCELERATE, 2015 - evacetrapib vs placebo

IMPROVE-IT, 2014 - ezetimibe vs control

dal-OUTCOMES, 2012 - dalcetrapib vs placebo

dal-VESSEL, 2011 - dalcetrapib vs placebo

AIM-HIGH, 2011 - niacin vs placebo (on top statin)

SEARCH, 2010 - simvastatin high dose vs simvastatin

ACCORD lipid, 2010 - fenofibrate vs placebo (on top simvastatine)

DEFINE, 2010 - anacetrapib vs placebo

SHARP, 2010 - ezetimibe+simvastatin vs placebo

ARBITER-HALTS 6, 2010 - ezetimibe vs niacin

ARBITER 2, 2009 - niacin vs placebo (on top statin)

Oxford Niaspan Study, 2009 - niacin vs placebo (on top statin)

Emmerich, 2009 - etofibrate vs placebo

ARBITER 6-HALTS (niacin vs ezetimibe), 2009 - niacin vs ezetimibe

SANDS, 2008 - aggressive treatment vs standard teatment

Tuttle, 2008 - low fat diet vs mediterranean-style diet

Guyton, 2008 - niacin+ezetimibe vs simvastatin+ezetimibe

GISSI-HF rosuvastatine, 2008 - rosuvastatin vs placebo

JUPITER, 2008 - rosuvastatin vs placebo

SAGE, 2007 - atorvastatin high dose vs pravastatin

RADIANCE 2, 2007 - torcetrapib vs placebo (on top of atorvastatin)

Krum, 2007 - rosuvastatin vs placebo

ILLUMINATE, 2007 - torcetrapib vs placebo (on top of atorvastatin)

CORONA, 2007 - rosuvastatin vs placebo

METEOR, 2007 - rosuvastatin vs placebo

See also:

  • All cardiovascular prevention clinical trials
  • All clinical trials of niacin
  • All clinical trials of niacin
     Oxford Niaspan Study study, 2009 TRC10051 
    [NCT00232531] download pdf: niacin | cholesterol lowering intervention for cardiovascular prevention


    Studied treatment niacin 2g daily (added to statin therapy)
    Control treatment placebo (statins alone)
    Concomittant treatment statin therapy


    Patients patients with low HDL-C (<40 mg/dl) and either a type 2 diabetes with coronary heart disease or a carotid/peripheral atherosclerosis
    Inclusion criteria 1) HDL-C <40 mg/dl in the previous 12 months together with either: 2a) carotid atherosclerosis (30% to 70% stenosis identified using carotid ultrasound); 2b) peripheral arterial disease (ankle-brachial pressure index <0.9); or 2c) type 2 diabetes with coronary artery disease (>50% stenosis of major epicardial vessel at angiography). There was no specific LDL-C inclusion criterion, but all patients were already taking statins
    Exclusion criteria contraindications to MRI or to NA (e.g., elevated liver enzymes or known intolerance); severe carotid stenosis (>70%); existing treatment with fibrates, nicorandil, or oral nitrates; recent acute coronary syndrome; uncontrolled diabetes; fasting triglyceride level >500 mg/dl; active peptic ulcer disease; and cardiac failure requiring diuretic treatment
    Baseline characteristics
    Male (%) 94% 
    Age (years) 65y 
    Diabetes (%) 64% 

    Method and design

    Randomized effectives 35 / 36 (studied vs. control)
    Design Parallel groups
    Blinding double blind
    Follow-up duration 1 year
    Number of centre single-center
    Geographic area USA
    Hypothesis Superiority
    Primary endpoint carotid artery wall area


    No results available for this trial - no clinical endpoint reported

    Meta-analysis of all similar trials:

    cholesterol lowering intervention in cardiovascular prevention for all chronical situations

    HDL increasing drugs in cardiovascular prevention for all type of patients

    niacin in cardiovascular prevention for all type of patients


    TrialResults-center ID TRC10051
    Trials register # NCT00232531
    • Lee JM, Robson MD, Yu LM, Shirodaria CC, Cunnington C, Kylintireas I, Digby JE, Bannister T, Handa A, Wiesmann F, Durrington PN, Channon KM, Neubauer S, Choudhury RP. Effects of high-dose modified-release nicotinic Acid on atherosclerosis and vascular function a randomized, placebo-controlled, magnetic resonance imaging study.. J Am Coll Cardiol 2009;54:1787-94
      Pubmed | Hubmed | Fulltext

    (c) 2004-2016 TrialResults-center - All Rights Reserved

    Tweet this  |  Facebook  |  notify a friend

    100Heart and vessels