Trial-Results center  
Clinical trial results database Feedback    Home


Related trials

Lopaciuk, 3000 - subcutaneous heparin vs intravenous heparin

RE-COVER, 2009 - dabigatran vs vitamin K antagonists

EINSTEIN-extension, 2009 - rivaroxaban vs placebo

Romera, 2009 - Tinzaparin vs acenocoumarol

González-Fajardo, 2008 - Enoxaparin vs coumarin

Botticelli DVT, 2008 - apixaban vs heparin/VKA

Einstein-DVT Dose-Ranging Study, 2008 - rivaroxaban vs heparin/VKA

VanGogh DVT, 2007 - idraparinux vs heparin/VKA

VanGogh PE, 2007 - idraparinux vs heparin/VKA

Daskalopoulos, 2005 - LMWH at home vs UFH in hospital

Fiessinger , 2005 - ximelagatran vs vitamin K antagonists

Chong, 2005 - LMWH at home vs UFH in hospital

Kearon, 2004 - 4 months vs 3 months

Ramacciotti, 2004 - LMWH at home vs UFH in hospital

MATISSE, 2004 - fondaparinux vs enoxaparin

Lee, 2003 - Dalteparin vs warfarin

Agnelli, 2003 - 6-12 months vs 3 months

Kakkar, 2003 - Bemiparin vs warfarin

Deitcher, 2003 - Enoxaparin vs warfarin

MATISSE PE, 2003 - fondaparinux vs heparin/VKA

Hull, 2002 - Tinzaparin vs warfarin

Meyer, 2002 - Enoxaparin vs warfarin

Agnelli, 2001 - 12 months vs 3 months

Merli (once daily vs UFH), 2001 - once daily enoxaparin vs UFH

Lopez-Beret, 2001 - Nadroparin vs acenocoumarol



See also:

  • All venous thrombosis clinical trials
  •  

    Botticelli DVT study, 2008

    [NCT00252005]

    Treatments

    Studied treatment apixaban 5 mg twice-daily, 10 mg twice-daily, or 20 mg once-daily for 84-91 days
    Control treatment low molecular weight heparin followed by vitamin K antagonists

    Patients

    Patients patients with symptomatic deep vein thrombosis
    Inclusion criteria symptomatic proximal DVT or extensive calf vein thrombosis, involving at least the upper third of the deep calf veins (trifurcation area) confirmed by compression ultrasonography (CUS) or venography
    Exclusion criteria symptomatic pulmonary embolism; creatinine clearance below 30 mL/min;impaired liver function; caval filter, fibrinolytic agent for the current episode; indications for VKAs other than DVT; more than 24 h of prerandomization treatment with therapeutic doses of unfractionated heparin, LMWH or fondaparinux or more than a single starting dose of VKA prior to randomization; active bleeding or high risk for bleeding contraindicating treatment with LMWH, fondaparinux or VKA; systolic blood pressure higher than 200 mmHg or diastolic blood pressure higher than 110 mmHg; more than 165 mg of acetylsalicylic acid/day; childbearing potential without adequate contraception; pregnancy; breast-feeding; any other contraindication listed in the local labeling of enoxaparin, tinzaparin fondaparinux, warfarin, acenocoumarol, or phenprocoumon

    Method and design

    Randomized effectives 358 / 118 (studied vs. control)
    Design Parallel groups
    Blinding open
    Hypothesis Superiority
    Primary endpoint recurrent VTE or asymptomatic deterioration in the
    Remarks dose-ranging study; the primary efficacy endpoint was the composite of symptomatic recurrent venous thromboembolism and asymptomatic deterioration of bilateral compression ultrasound or perfusion lung scan


    Results

    No results available for this trial - no clinical endpoint reported



    Reference(s)

    Trials register # NCT00252005
    • Buller H, Deitchman D, Prins M, Segers A. Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study.. J Thromb Haemost 2008 Aug;6:1313-8
      Pubmed | Hubmed | Fulltext

    (c) 2004-2010 TrialResults-center - All Rights Reserved

    Tweet this  |  notify a friend