Related trials
Lopaciuk, 3000 - subcutaneous heparin vs intravenous heparin
RE-COVER, 2009 - dabigatran vs vitamin K antagonists
Romera, 2009 - Tinzaparin vs acenocoumarol
Gonz�lez-Fajardo, 2008 - Enoxaparin vs coumarin
Botticelli DVT, 2008 - apixaban vs heparin/VKA
Einstein-DVT Dose-Ranging Study, 2008 - rivaroxaban vs heparin/VKA
VanGogh DVT, 2007 - idraparinux vs heparin/VKA
VanGogh PE, 2007 - idraparinux vs heparin/VKA
Daskalopoulos, 2005 - LMWH at home vs UFH in hospital
Fiessinger , 2005 - ximelagatran vs vitamin K antagonists
Chong, 2005 - LMWH at home vs UFH in hospital
Kearon, 2004 - 4 months vs 3 months
Ramacciotti, 2004 - LMWH at home vs UFH in hospital
MATISSE, 2004 - fondaparinux vs enoxaparin
Lee, 2003 - Dalteparin vs warfarin
Agnelli, 2003 - 6-12 months vs 3 months
Kakkar, 2003 - Bemiparin vs warfarin
Deitcher, 2003 - Enoxaparin vs warfarin
MATISSE PE, 2003 - fondaparinux vs heparin/VKA
Hull, 2002 - Tinzaparin vs warfarin
Meyer, 2002 - Enoxaparin vs warfarin
Agnelli, 2001 - 12 months vs 3 months
Merli (once daily vs UFH), 2001 - once daily enoxaparin vs UFH
Lopez-Beret, 2001 - Nadroparin vs acenocoumarol
Merli, 2001 - once daily enoxaparin vs twice daily enoxaparin
See also:
All venous thrombosis clinical trials
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Treatments
Studied treatment |
LMWH: 1a, 1 mg/kg q12h; 1b, 1 mg/kg qd12h followed by Enoxaparin 1a: 1 mg/kg qd; 1b: 1.5 mg/kg qd
|
Control treatment |
LMWH, 1 mg/kg q12h followed by Warfarin target INR 2-3
|
Patients
Patients |
patients with objective diagnosis of DVT |
Baseline characteristics |
objective DVT diagnosis |
NA |
objective PR diagnosis |
Unknown |
cancer (%) |
100% |
Outcome assessment blinded |
NA |
|
Method and design
Randomized effectives |
51 / 30 (studied vs. control) |
Blinding |
open |
Follow-up duration |
6 mo |
Number of centre |
multicenter |
Results
Endpoint
Studied treat. n/N
Control treat. n/N
Graph
RR [95% CI]
VTE during active anticoagulant treatment
2 / 51
2 / 30
classic
0,59 [0,09;3,96]
0
2
1.0
Relative risks
|
Endpoint |
Events (%) |
Relative Risk |
95% CI |
Endpoint definition in the trial |
Studied treat. |
Control treat. |
VTE during active anticoagulant treatment
|
2 / 51 (3,9%) |
2 / 30 (6,7%) |
0,59 |
[0,09;3,96] |
|
The primary endpoint (if exists) appears in blod characters
|
Endpoint |
studied treat. |
control treat. |
mean diff |
Absolute risk reduction
|
Endpoint |
Events rate |
Absolute risk reduction (ARR) |
Studied treat. |
Control treat. |
VTE during active anticoagulant treatment |
3,92% |
6,67% |
-27,5‰
|
Reference(s)
-
Deitcher SR, Kessler MG, Lyons RM., imag.
Treatment of venous
thromboembolic events (VTE) in patients with active malignancy:
a randomized study of enoxaparin alone versus initial
enoxaparin followed by warfarin for a 180-day period [abstract].s-e.
Blood 2003; 102:322a
Pubmed
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Hubmed
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