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See also:

  • All venous thrombosis clinical trials
  •  

    Hull study, 2002

    Treatments

    Studied treatment LMWH, 175 IU/kg qd followed by Tinzaparin 175 IU/kg qd
    Control treatment UFH 5 d, followed by UFH therapeutic APTT followed by Warfarin target INR 2-3

    Patients

    Patients patients with objective diagnosis of DVT by Venography/compression ultrasonography
    Baseline characteristics
    objective DVT diagnosis Venography/CUS 
    objective PR diagnosis not applicable 
    cancer (%) 28%  
    Outcome assessment blinded NA 

    Method and design

    Randomized effectives 369 / 368 (studied vs. control)
    Blinding open
    Follow-up duration 9 mo
    Number of centre multicenter


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    VTE during active anticoagulant treatment

    16 / 369
    21 / 368
    0,76 [0,40;1,43]

    VTE during follow-up after active anticoagulant treatment

    15 / 344
    15 / 344
    classic 1,00 [0,50;2,01]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Studied treat. Control treat.
    VTE during active anticoagulant treatment 16 / 369 (4,3%) 21 / 368 (5,7%) 0,76 [0,40;1,43]  
    VTE during follow-up after active anticoagulant treatment 15 / 344 (4,4%) 15 / 344 (4,4%) 1,00 [0,50;2,01]  
    The primary endpoint (if exists) appears in blod characters

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    VTE during active anticoagulant treatment 4,34% 5,71% -13,7‰
    VTE during follow-up after active anticoagulant treatment 4,36% 4,36% 0,0‰


    Reference(s)

    Trials register # NA
    • Hull RD, Pineo GF, Mah AF, et al, for the LITE Study. A randomized trial evaluating long-term lowmolecular- weight heparin therapy for three months versus intravenous heparin followed by warfarin sodium [abstract].582258. Blood 2002; 100:148a
      Pubmed | Hubmed | Fulltext

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