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See also:

  • All venous thrombosis clinical trials
  •  

    Meyer study, 2002

    Treatments

    Studied treatment LMWH, 1.5 mg/kg qd followed by Enoxaparin 1.5 mg/Kg qd
    Control treatment LMWH, 1.5 mg/kg qd followed by Warfarin target INR 2-3

    Patients

    Patients patients with cancer and objective diagnosis of DVT by Venography/compression ultrasonography
    Baseline characteristics
    objective DVT diagnosis Venography/CUS 
    objective PR diagnosis PA/VPLS 
    cancer (%) 100%  
    Outcome assessment blinded Yes 

    Method and design

    Randomized effectives 71 / 58 (studied vs. control)
    Blinding open
    Follow-up duration 3 mo
    Number of centre multicenter
    Primary endpoint major bleeding or recurrent venous thromboembolism


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    VTE during follow-up after active anticoagulant treatment

    3 / 63
    0 / 58
    classic 11,97 [0,21;688,54]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Studied treat. Control treat.
    VTE during follow-up after active anticoagulant treatment 3 / 63 (4,8%) 0 / 58 (0,9%) 5,52 [0,28;107,95]  
    The primary endpoint (if exists) appears in blod characters

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.


    Reference(s)

    Trials register # NA
    • Meyer G, Marjanovic Z, Valcke J, Lorcerie B, Gruel Y, Solal-Celigny P, Le Maignan C, Extra JM, Cottu P, Farge D. Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study.. Arch Intern Med 2002;162:1729-35
      Pubmed | Hubmed | Fulltext

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