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See also:

  • All venous thrombosis clinical trials
  •  

    Lopez-Beret study, 2001

    Treatments

    Studied treatment LMWH, 1,025 IU/10 kg bid followed by Nadroparin 1,025 IU/10 kg bid
    Control treatment LMWH, 1,025 IU/10 kg bid followed by Acenocoumarol target INR 2-3

    Patients

    Patients patients with objective diagnosis of DVT by compression ultrasonography
    Baseline characteristics
    objective DVT diagnosis CUS 
    objective PR diagnosis HCT/PA 
    cancer (%) 22.1%  
    Outcome assessment blinded Yes 

    Method and design

    Randomized effectives 81 / 77 (studied vs. control)
    Blinding open
    Follow-up duration 6-9 mo
    Number of centre single center
    Primary endpoint none defined


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    VTE during active anticoagulant treatment

    9 / 81
    3 / 77
    classic 2,85 [0,80;10,14]

    VTE during follow-up after active anticoagulant treatment

    2 / 74
    4 / 74
    classic 0,50 [0,09;2,65]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Studied treat. Control treat.
    VTE during active anticoagulant treatment 9 / 81 (11,1%) 3 / 77 (3,9%) 2,85 [0,80;10,14]  
    VTE during follow-up after active anticoagulant treatment 2 / 74 (2,7%) 4 / 74 (5,4%) 0,50 [0,09;2,65]  
    The primary endpoint (if exists) appears in blod characters

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    VTE during active anticoagulant treatment 11,11% 3,90% 7,2%
    VTE during follow-up after active anticoagulant treatment 2,70% 5,41% -27,0‰


    Reference(s)

    Trials register # NA
    • López-Beret P, Orgaz A, Fontcuberta J, Doblas M, Martinez A, Lozano G, Romero A. Low molecular weight heparin versus oral anticoagulants in the long-term treatment of deep venous thrombosis.. J Vasc Surg 2001;33:77-90
      Pubmed | Hubmed | Fulltext

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