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See also:
All cardiovascular prevention clinical trials
All clinical trials of lifestyle intervention
All clinical trials of Multiple risk factor interventions
|
|
Treatments
Studied treatment |
Multifactorial prevention of cardiovascular diseases
dietetic-hygienic measures and hypolipidemic (mainly probucol and clofibrate) and antihypertensive (mainly diuretics and beta-blockers) agents
|
Control treatment |
no intervention
|
Patients
Patients |
healthy men 40-58 y at high risk |
Baseline characteristics |
Age (yr) |
48 y |
Age range (yr) |
40-55 |
interventions |
Diet, smoking, exercise, antihypertensive drugs, cholesterol lowering drugs |
|
Method and design
Randomized effectives |
612 / 610 (studied vs. control) |
Design |
Parallel groups |
Blinding |
open |
Follow-up duration |
5 yr |
Number of centre |
2 |
Geographic area |
Finland |
Primary endpoint |
total mortality |
Results
Endpoint
Studied treat. n/N
Control treat. n/N
Graph
RR [95% CI]
All cause death
10 / 612
5 / 610
classic
1,99 [0,69;5,80]
Smoking prevalence
125 / 575
131 / 580
0,96 [0,78;1,19]
Coronary death
4 / 612
1 / 610
classic
3,99 [0,45;35,57]
0
2
1.0
Relative risks
|
Endpoint |
Events (%) |
Relative Risk |
95% CI |
Endpoint definition in the trial |
Ref |
Studied treat. |
Control treat. |
All cause death
|
10 / 612 (1,6%) |
5 / 610 (0,8%) |
1,99 |
[0,69;5,80] |
|
0 |
Smoking prevalence
|
125 / 575 (21,7%) |
131 / 580 (22,6%) |
0,96 |
[0,78;1,19] |
|
|
Coronary death
|
4 / 612 (0,7%) |
1 / 610 (0,2%) |
3,99 |
[0,45;35,57] |
|
0 |
The primary endpoint (if exists) appears in blod characters
|
Reference(s) used for data extraction:
0:
8304: Ketola E, Sipil� R, M�kel� MEffectiveness of individual lifestyle interventions in reducing cardiovascular disease and risk factors.Ann Med 2000;32:239-51
|
Endpoint |
studied treat. |
control treat. |
mean diff |
Absolute risk reduction
|
Endpoint |
Events rate |
Absolute risk reduction (ARR) |
Studied treat. |
Control treat. |
All cause death |
1,63% |
8,20‰ |
8,1‰
|
Smoking prevalence |
21,74% |
22,59% |
-8,5‰
|
Coronary death |
6,54‰ |
1,64‰ |
4,9‰
|
Meta-analysis of all similar trials:
lifestyle intervention in cardiovascular prevention for all type of patients
lifestyle intervention in cardiovascular prevention for primary prevention
Reference(s)
-
Miettinen TA, Huttunen JK, Naukkarinen V, Strandberg T, Mattila S, Kumlin T, Sarna S.
Multifactorial primary prevention of cardiovascular diseases in middle-aged men. Risk factor changes, incidence, and mortality..
JAMA 1985;254:2097-102
Pubmed
|
Hubmed
| Fulltext
-
Strandberg TE, Salomaa VV, Naukkarinen VA, Vanhanen HT, Sarna SJ, Miettinen TA.
Long-term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle-aged men..
JAMA 1991;266:1225-9
Pubmed
|
Hubmed
| Fulltext
-
Strandberg TE, Salomaa VV, Vanhanen HT, Naukkarinen VA, Sarna SJ, Miettinen TA.
Mortality in participants and non-participants of a multifactorial prevention study of cardiovascular diseases: a 28 year follow up of the Helsinki Businessmen Study..
Br Heart J 1995;74:449-54
Pubmed
|
Hubmed
| Fulltext
|