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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

cardiovascular prevention - lifestyle intervention - all type of patients

cardiovascular prevention - lifestyle intervention - primary prevention


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Helsinki Businessmen Study, 1985 - Multiple risk factor interventions vs control

Finnish Mental Hospital (Miettinen), 1985 - diet vs usual diet

Johns Hopkins, 1983 - Multiple risk factor interventions vs control

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See also:

  • All cardiovascular prevention clinical trials
  • All clinical trials of lifestyle intervention
  • All clinical trials of Multiple risk factor interventions
    		•  

    Helsinki Businessmen Study study, 1985

    download pdf: Multiple risk factor interventions | lifestyle intervention for cardiovascular prevention

    Treatments

    Studied treatment Multifactorial prevention of cardiovascular diseases
    dietetic-hygienic measures and hypolipidemic (mainly probucol and clofibrate) and antihypertensive (mainly diuretics and beta-blockers) agents
    Control treatment no intervention

    Patients

    Patients healthy men 40-58 y at high risk
    Baseline characteristics
    Age (yr) 48 y 
    Age range (yr) 40-55 
    interventions Diet, smoking, exercise, antihypertensive drugs, cholesterol lowering drugs 

    Method and design

    Randomized effectives 612 / 610 (studied vs. control)
    Design Parallel groups
    Blinding open
    Follow-up duration 5 yr
    Number of centre 2
    Geographic area Finland
    Primary endpoint total mortality


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    All cause death

    10 / 612
         5 / 610
         classic 1,99 [0,69;5,80]

    Smoking prevalence

    125 / 575
         131 / 580
         0,96 [0,78;1,19]

    Coronary death

    4 / 612
         1 / 610
         classic 3,99 [0,45;35,57]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    All cause death 10 / 612 (1,6%) 5 / 610 (0,8%) 1,99 [0,69;5,80] 0
    Smoking prevalence 125 / 575 (21,7%) 131 / 580 (22,6%) 0,96 [0,78;1,19]
    Coronary death 4 / 612 (0,7%) 1 / 610 (0,2%) 3,99 [0,45;35,57] 0
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 0:
  • 8304: Ketola E, Sipil� R, M�kel� MEffectiveness of individual lifestyle interventions in reducing cardiovascular disease and risk factors.Ann Med 2000;32:239-51

    • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    All cause death 1,63% 8,20‰ 8,1‰
    Smoking prevalence 21,74% 22,59% -8,5‰
    Coronary death 6,54‰ 1,64‰ 4,9‰

    Meta-analysis of all similar trials:

    lifestyle intervention in cardiovascular prevention for all type of patients

    lifestyle intervention in cardiovascular prevention for primary prevention



    Reference(s)

    Trials register # NA
    • Miettinen TA, Huttunen JK, Naukkarinen V, Strandberg T, Mattila S, Kumlin T, Sarna S. Multifactorial primary prevention of cardiovascular diseases in middle-aged men. Risk factor changes, incidence, and mortality.. JAMA 1985;254:2097-102
      Pubmed | Hubmed | Fulltext
    • Strandberg TE, Salomaa VV, Naukkarinen VA, Vanhanen HT, Sarna SJ, Miettinen TA. Long-term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle-aged men.. JAMA 1991;266:1225-9
      Pubmed | Hubmed | Fulltext
    • Strandberg TE, Salomaa VV, Vanhanen HT, Naukkarinen VA, Sarna SJ, Miettinen TA. Mortality in participants and non-participants of a multifactorial prevention study of cardiovascular diseases: a 28 year follow up of the Helsinki Businessmen Study.. Br Heart J 1995;74:449-54
      Pubmed | Hubmed | Fulltext

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