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See also:

  • All test diabète clinical trials
  • All diabetes clinical trials
  • All type 2 diabetes - sanofi clinical trials
  • All clinical trials of insulin secretagogues peptides (incretins)
  • All clinical trials of liraglutide
    		•  

    Madsbad (vs placebo) study, 2004

    download pdf: liraglutide | insulin secretagogues peptides (incretins) for diabetes

    Treatments

    Studied treatment Liraglutide 0.045–0.75 mg daily
    Control treatment Placebo
    Concomittant treatment None

    Patients

    Baseline characteristics
    Age (year) 57  
    Duration of diabetes (year) 4.5 y 
    HbA1c (%) 7.5 
    BMI 30.4 
    Add-on to None 

    Method and design

    Randomized effectives 135 / 29 (studied vs. control)
    Blinding open
    Follow-up duration 12 weeks


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    severe hypoglycemia

    0 / 135
         0 / 29
         classic 0,21 [0,00;54,12]

    diarrhoea

    5 / 135
         0 / 29
         classic 4,51 [0,08;244,37]

    All cause death

    0 / 135
         0 / 29
         classic 0,21 [0,00;54,12]

    all hypoglycemia

    1 / 135
         0 / 29
         classic 1,07 [0,01;77,23]

    vomiting

    3 / 135
         0 / 29
         classic 2,79 [0,05;159,99]

    cardiovascular events

    0 / 135
         0 / 29
         classic 0,21 [0,00;54,12]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    severe hypoglycemia 0 / 135 (0,4%) 0 / 29 (1,7%) 0,21 [0,00;10,61] 12053
    vomiting 3 / 135 (2,2%) 0 / 29 (1,7%) 1,29 [0,07;25,05] 12053
    cardiovascular events 0 / 135 (0,4%) 0 / 29 (1,7%) 0,21 [0,00;10,61] 12053
    all hypoglycemia 1 / 135 (0,7%) 0 / 29 (1,7%) 0,43 [0,01;12,51] 12053
    diarrhoea 5 / 135 (3,7%) 0 / 29 (1,7%) 2,15 [0,12;38,24] 12053
    All cause death 0 / 135 (0,4%) 0 / 29 (1,7%) 0,21 [0,00;10,61] 12053
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 12053: Monami M, Marchionni N, Mannucci EGlucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized clinical trials.Eur J Endocrinol 2009;160:909-17
  • 0:

    • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.

    Meta-analysis of all similar trials:

    antidiabetic drugs in test diabète for type 2 daibetes (NIDD)

    insulin secretagogues peptides (incretins) in diabetes for all type of patients

    insulin secretagogues peptides (incretins) in type 2 diabetes - sanofi for all type of patients



    Reference(s)

    Trials register # NA
    • Madsbad S, Schmitz O, Ranstam J, Jakobsen G, Matthews DR. Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial.. Diabetes Care 2004;27:1335-42
      Pubmed | Hubmed | Fulltext

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