MRFIT, 1982 trial summary

A randomised clinical trial investigating the effect of Multiple risk factor interventions versus control in high-risk men aged 35 to 57 years

Studied treatment	special intervention (SI) program consisting of stepped-care treatment for hypertension, counseling for cigarette smoking, and dietary advice for lowering blood cholesterol levels
Control treatment	no intervention
Age (yr)	46 y
Age range (yr)	35-47
interventions	Diet, smoking, weight, antihypertensive drugs

Patients	high-risk men aged 35 to 57 years
Group sizes	6428 / 6438

Blindness	open	Inclusion period
Follow-up duration	6 yr	Centers
Lost to FU		geographical localisation
Primary endpoint		Design	Parallel groups

Randomisation of individuals

Mortality rates after 10.5 years for participants in the Multiple Risk Factor Intervention Trial. Findings related to a priori hypotheses of the trial. The Multiple Risk Factor Intervention Trial Research Group. JAMA 1990;263:1795-801 [PMID: 2179590] link to pdf add to Mendeley

Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. JAMA 1982;248:1465-77 [PMID: 7050440] link to pdf add to Mendeley

ClinicalTrial.gov record NCT00000487?acronym=

Registering number	NCT00000487?acronym= (see trial on clinicaltrials.gov)
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