PATS, 1995 trial summary    PDF trial summary

A randomised clinical trial investigating the effect of indapamide versus placebo in

        Z

Chin Med J (Engl) 1995;108:710-7  



Studied treatment indapamide 2.5 mg/d
Control treatment placebo
Female (%) 28%
Age 60 y



Patients
Group sizes2841 / 2841
Inclusion criteriamen and women with history of TIA or stroke not severely disabled, irrespective of their blood pressure
Exclusion criterianeoplasm, rheumatic valvular disease, congestive cardiomyopathy, atrial fibrillation, secondary hypertension, hyperthyroidism, renal and hepatic disease, haemorrhagic disease, insulin dependent diabetes
Inclusion SBP nil
Inclusion DBP nil
Number of selection measures
prior cardiovascular disease
prior stroke
heart failure
Diabetes (%)
prior myocardial infarction (%)



Blindness Double blind Inclusion period
Follow-up duration 2y Centers
Lost to FU ND geographical localisation China
Primary endpoint Design Parallel groups
ArretTrt1ND
HypotheseSuperiority
baseline BP 154/93 (80-280/50-150)
Isolated systolic hypertension



EndpointX1N1X0N0TE95% CI myocardial infarction (fatal and non fatal) - 2841 - 2841 no data Heart failure - 2841 - 2841 no data Stroke 159 2841 217 2841 0,73[0,59; 0,91] All-cause death 146 2841 158 2841 0,92[0,73; 1,16] Coronary event 25 2841 21 2841 1,19[0,66; 2,13] Cardiovascular death 87 2841 101 2841 0,86[0,64; 1,15] cardiovascular event 247 2841 194 2841 1,27[1,05; 1,55] fatal stroke 60 2841 77 2841 0,78[0,55; 1,10] cardiovascular death 87 2841 101 2841 0,86[0,64; 1,15] coronary death 17 2841 13 2841 1,31[0,63; 2,70]0,22,01,0

Post-stroke antihypertensive treatment study. A preliminary result. PATS Collaborating Group. Chin Med J (Engl) 1995;108:710-7     [PMID: 8575241]   link to pdf   add to Mendeley  



Registering number (see trial on clinicaltrials.gov)
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All trials of indapamide

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