ASTRONOMER, 2010 trial summary    PDF trial summary

A randomised clinical trial investigating the effect of rosuvastatin versus placebo in asymptomatic patients with mild to moderate aortic stenosis and no clinical indications for cholesterol lowering

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ISRCTN 32424163    Circulation 2010 Jan 4;:
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Studied treatment rosuvastatin 40 mg daily
Control treatment placebo



Patients asymptomatic patients with mild to moderate aortic stenosis and no clinical indications for cholesterol lowering
Group sizes134 / 135



Blindness double blind Inclusion period
Follow-up duration 3.5 y Centers
Lost to FU geographical localisation
Primary endpoint Design Parallel groups



EndpointX1N1X0N0TE95% CI - -9 - -9 no data 102 -9 67 -9 no data CV death - 134 - 135 no data Death from any cause - 134 - 135 no data Aortic-valve replacement - 134 - 135 no data Hospitalization for severe aortic stenosis - 134 - 135 no data CV detah, aortic replacement, hospitalization for severe aortic stenosis - 134 - 135 no data - 134 - 135 no data0,22,01,0

Chan KL, Teo K, Dumesnil JG, Ni A, Tam J Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis. Results of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial. Circulation 2010 Jan 4;:     [PMID: 20048204]   link to pdf   add to Mendeley  

ClinicalTrial.gov record ISRCTN 32424163



Registering number ISRCTN 32424163 (see trial on clinicaltrials.gov)
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All trials of rosuvastatin

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