Dickler (CALGB 40503°, 2015 trial summary

A randomised clinical trial investigating the effect of Letrozole plus bevacizumab versus letrozole in

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Studied treatment
Control treatment



Patients
Group sizes-9 / -9



Blindness Inclusion period
Follow-up duration Centers
Lost to FU geographical localisation
Primary endpoint Design



EndpointX1N1X0N0TE95% CI objective response - -9 - -9 no data progression-free survival (PFS) - -9 - -9 no data overall survival (OS) - -9 - -9 no data wound-healing complications (grade 3) - -9 - -9 no data treatment-related deaths - -9 - -9 no data hypertension (grade 3) - -9 - -9 no data arterial thromboembolic event - -9 - -9 no data gastrointestinal perforation (grade 3) - -9 - -9 no data left ventricular systolic dysfunction (grade 2 or 3) - -9 - -9 no data high-grade congestive heart failure - -9 - -9 no data serious adverse events - -9 - -9 no data arterial/venous thromboembolism (grade 3) - -9 - -9 no data pulmonary embolism (grade 3) - -9 - -9 no data bleeding (grade 3) - -9 - -9 no data cardiomyopathy (grade 3) - -9 - -9 no data permanent discontinuation - -9 - -9 no data adverse events grade 3 - -9 - -9 no data venous thromboembolic event (grade 3) - -9 - -9 no data proteinuria (grade 3) - -9 - -9 no data0,22,01,0

Dickler M, Barry WT, Cirrincione C, Ellis MJ, Moynahan ME, Innocenti F. Phase III trial evaluating the additionof bevacizumab to letrozole as first-line endocrine therapyfor treatment of hormone-receptor positive advancedbreast cancer: CALGB 40503 (Alliance). J Clin Oncol 2015;33 (suppl; abstr 501).     [PMID: ]   link to pdf   add to Mendeley  

    [PMID: ]   link to pdf   add to Mendeley  



Registering number (see trial on clinicaltrials.gov)
Code Name

 

All trials of Letrozole plus bevacizumab

Appears in following systematic reviews:

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