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plasma homocysteine lowering intervention in cardiovascular prevention for all type of patients, clinical trials results

folic acid versus control
FOLARDA (Liem), 2004	folic acid 5 mg per day for 1 year versus usual care	patients with acute MI and total cholesterol >6.5 mmol/l	open Follow-up duration: 1 year The Netherlands
GOES (Liem), 2003	folic acid 0.5 mg per day versus usual care	patients with stable coronary artery disease	open Follow-up duration: 24 months The Netherlands
folic acid versus placebo
CSPPT, 2015 NCT00794885	enalapril 10 mg / folic acid 0.8 mg daily versus Enalapril maleate 10 mg daily	patients with primary hypertension	double-blind China
CHAOS-2, 2002	folic acid 5 mg per day (for 2 years) versus placebo	patient with CHD	double blind Follow-up duration: 1.7 y
folic acid, B12 versus control
NORVIT (folic acid + B12) (Bonaa), 2006 NCT00266487	folic acid 0.8mg and B12 0.4 mg daily versus no folic acid and B12	men and women who had had an acute myocardial infarction within seven days before	double-blind Follow-up duration: 36 months Norway
folic acid, B12 versus placebo
WENBIT (folic ac,B12), 2008 NCT00354081	folic acid 0.8mg, vit B12 0.4mg daily versus placebo	adult participants undergoing coronary angiography	double blind Follow-up duration: 38.4 mo Norway
SEARCH, 2007 NCT00124072	folic acid 2mg/d + vitamin B12 1mg/d versus placebo	patients survivors of myocardial infarction	double blind Follow-up duration: 7 years UK
folic acid, vit B12 and vit B6 versus control
NORVIT (folic acid, B12 and vit B6) (Bonaa), 2006 NCT00266487	0.8 mg of folic acid, 0.4 mg of vitamin B12, and 40 mg of vitamin B6 versus placebo	men and women who had had an acute myocardial infarction within seven days	double-blind Follow-up duration: 36 months Norway
folic acid, vit B12 and vit B6 versus placebo
VITATOPS, 2010 NCT00097669ÐX&	folic acid and vitamins B12 and B6 in a single tablet versus placebo	patients with recent stroke or TIA (within the past seven months)	double-blind Follow-up duration: 3.4 y 20 countries
SU.FOL.OM3, ISRCTN41926726	supplementation with natural foLate, vitamin B6 and B12 versus placebo	patients with coronary or cerebral event within the previous 12 months	double-blind France
HOPE-2 (Lonn), 2006 NCT00106886	folic acid, 2.5 mg, vitamin B6,50 mg and vitamin B12, 1mg versus placebo	patients 55 years of age or older who had vascular disease or diabetes and additional risk factors for atherosclerosis	double blind Follow-up duration: Jan 2000 - dec 2000 13 countries
WAFACS, 2008 NCT00000541	folic acid 2.5mg, vitamin B6 50mg, and vitamin B12 1mg daily versus placebo	women aged 42 years or older, with either a history of CVD or 3 or more coronary risk factors	double blind Follow-up duration: 7.3 y US
high dose - folic acid, vit B12 and vit B6 versus low dose - folic acid, vit B12 and vit B6
VISP (Toole), 2004	high-dose of folic acid, pyridoxine (vitamin B6), and cobalamin (vitamin B12) versus low-dose of folic acid, pyridoxine (vitamin B6), and cobalamin (vitamin B12)	adults with nondisabling cerebral infarction	double blind Follow-up duration: 2 y United States, Canada, Scotland
vit B6 versus control
NORVIT (vit B6) (Bonaa), 2006 NCT00266487	vit B6 40 mg daily versus no vit B6	men and women who had had an acute myocardial infarction within seven days	double-blind Follow-up duration: 36 months Norway
vit B6 versus placebo
WENBIT (vit B6), 2008 NCT00354081	vit B6 40mg daily versus placebo	adult participants undergoing coronary angiography	double blind Follow-up duration: 38.4 mo Norway

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