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plasma homocysteine lowering intervention in cardiovascular prevention for all type of patients, clinical trials results

folic acid versus control
FOLARDA (Liem), 2004
folic acid 5 mg per day for 1 year
versus
usual care
patients with acute MI and total cholesterol >6.5 mmol/l open
Follow-up duration: 1 year
The Netherlands
GOES (Liem), 2003
folic acid 0.5 mg per day
versus
usual care
patients with stable coronary artery diseaseopen
Follow-up duration: 24 months
The Netherlands
folic acid versus placebo
CSPPT, 2015
NCT00794885
enalapril 10 mg / folic acid 0.8 mg daily
versus
Enalapril maleate 10 mg daily
patients with primary hypertension double-blind
China
CHAOS-2, 2002
folic acid 5 mg per day (for 2 years)
versus
placebo
patient with CHDdouble blind
Follow-up duration: 1.7 y
folic acid, B12 versus control
NORVIT (folic acid + B12) (Bonaa), 2006
NCT00266487
folic acid 0.8mg and B12 0.4 mg daily
versus
no folic acid and B12
men and women who had had an acute myocardial infarction within seven days before double-blind
Follow-up duration: 36 months
Norway
folic acid, B12 versus placebo
WENBIT (folic ac,B12), 2008
NCT00354081
folic acid 0.8mg, vit B12 0.4mg daily
versus
placebo
adult participants undergoing coronary angiography double blind
Follow-up duration: 38.4 mo
Norway
SEARCH, 2007
NCT00124072
folic acid 2mg/d + vitamin B12 1mg/d
versus
placebo
patients survivors of myocardial infarctiondouble blind
Follow-up duration: 7 years
UK
folic acid, vit B12 and vit B6 versus control
NORVIT (folic acid, B12 and vit B6) (Bonaa), 2006
NCT00266487
0.8 mg of folic acid, 0.4 mg of vitamin B12, and 40 mg of vitamin B6
versus
placebo
men and women who had had an acute myocardial infarction within seven days double-blind
Follow-up duration: 36 months
Norway
folic acid, vit B12 and vit B6 versus placebo
VITATOPS, 2010
NCT00097669ÐX&
folic acid and vitamins B12 and B6 in a single tablet
versus
placebo
patients with recent stroke or TIA (within the past seven months)double-blind
Follow-up duration: 3.4 y
20 countries
SU.FOL.OM3,
ISRCTN41926726
supplementation with natural foLate, vitamin B6 and B12
versus
placebo
patients with coronary or cerebral event within the previous 12 monthsdouble-blind
France
HOPE-2 (Lonn), 2006
NCT00106886
folic acid, 2.5 mg, vitamin B6,50 mg and vitamin B12, 1mg
versus
placebo
patients 55 years of age or older who had vascular disease or diabetes and additional risk factors for atherosclerosisdouble blind
Follow-up duration: Jan 2000 - dec 2000
13 countries
WAFACS, 2008
NCT00000541
folic acid 2.5mg, vitamin B6 50mg, and vitamin B12 1mg daily
versus
placebo
women aged 42 years or older, with either a history of CVD or 3 or more coronary risk factorsdouble blind
Follow-up duration: 7.3 y
US
high dose - folic acid, vit B12 and vit B6 versus low dose - folic acid, vit B12 and vit B6
VISP (Toole), 2004
high-dose of folic acid, pyridoxine (vitamin B6), and cobalamin (vitamin B12)
versus
low-dose of folic acid, pyridoxine (vitamin B6), and cobalamin (vitamin B12)
adults with nondisabling cerebral infarctiondouble blind
Follow-up duration: 2 y
United States, Canada, Scotland
vit B6 versus control
NORVIT (vit B6) (Bonaa), 2006
NCT00266487
vit B6 40 mg daily
versus
no vit B6
men and women who had had an acute myocardial infarction within seven days double-blind
Follow-up duration: 36 months
Norway
vit B6 versus placebo
WENBIT (vit B6), 2008
NCT00354081
vit B6 40mg daily
versus
placebo
adult participants undergoing coronary angiography double blind
Follow-up duration: 38.4 mo
Norway

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