cardiac arrest clinical trials results

active compression-decompression CPR versus standard CPR
Aufderheide, 2011
active compression-decompression cardiopulmonary resuscitation
versus
standard cardiopulmonary resuscitation
adults (presumed age or age >=18 years) who had a nontraumatic arrest of presumed cardiac causeopen
Follow-up duration: hospital discharge
USA
amiodarone versus lidocaine
ALIVE, 2002
intravenous amiodarone plus lidocaine placebo
versus
intravenous lidocaine plus amiodarone placebo
out-of-hospital ventricular fibrillation resistant to three shocks, intravenous epinephrine, and a further shock; or recurrent ventricular fibrillation after initially successful defibrillationdouble blind
Follow-up duration: 1 day
amiodarone versus placebo
ARREST, 1999
intravenous amiodarone 300mg
versus
placebo
Patients with cardiac arrest by ventricular fibrillation (or pulseless ventricular tachycardia) and not resuscitated after receiving three or more precordial shocksdouble blind
Automatic External Defibrillation versus Cardiopulmonary Resuscitation
HAT,
NCT00047411
Automatic External Defibrillation
versus
Cardiopulmonary Resuscitation
people who have had an anterior myocardial infarction open
PAD (Hallstrom), 2004
lay volunteers trained in cardiopulmonary resuscitation and the use of automated external defibrillators
versus
lay volunteers trained in cardiopulmonary resuscitation alone
open
US, Canada
compression-only CPR versus standard CPR
Rea, 2010
NCT00219687
dispatcher instructions to bystanders for performing CPR with chest compression alone
versus
dispatcher instructions to bystanders for performing CPR with chest compression plus rescue breathing
persons 18 years of age or older with out-of-hospital cardiac arrest open
Svensson, 2010
CT20080012
compression-only CPR
versus
standard CPR
Patients with suspected, witnessed, out-of-hospital cardiac arrest open
Hallstrom, 2000
CPR by chest compression alone
versus
CPR by chest compression plus mouth-to-mouth ventilation
open
Hallstrom + preliminary study,

versus
compressions first versus defibrillation first
Jost, 2010
chest compressions before defibrillation
versus
immediate defibrillation before chest compressions

France
Baker, 2008
chest compressions before defibrillation
versus
immediate defibrillation before chest compressions

Australia
Jacobs, 2005
chest compressions before defibrillation
versus
immediate defibrillation before chest compressions

Australia
Wik, 2003
chest compressions before defibrillation
versus
immediate defibrillation before chest compressions

Norway
fish oil versus placebo
Raitt , 2006
NCT00004558
Fish oil 1.3g
versus
placebo (olive oil)
double blind
SOFA , 2006
NCT00110838
Fish oil 0.9g
versus
placebo (High-oleic sunflower oil)
double blind
Follow-up duration: 356 days (14-379)
Europe
Leaf, 2005
Fish oil 2.6g
versus
placebo (olive oil)
t-PA versus placebo
Abu-Laban, 2002
t-PA 100mg over a 15-minute period
versus
placebo
Victims of cardiac arrest with pulseless electrical activity for more than one minute and had had no palpable pulse for more than three minutes during resuscitative efforts and at the time of the initiation of the study drugdouble blind
Canda
tenecteplase versus placebo
TROICA, 2008
NCT00157261
tenecteplase (dose according to estimated body weight)
versus
placebo
adults with witnessed out-of-hospital cardiac arrest of presumed cardiac origin and with initiation of basic or advanced life support within 10 minutes after collapsedoubel blind
Follow-up duration: 30 days
Europe
TICA, 2004
tenecteplase 50 mg
versus
placebo
All victims of out of hospital cardiac arrestdouble blind
Australia
vasopressin versus epinephrine
Lindner, 1997
Vasopressin 40 U IV
versus
epinephrine 1 mg intravenously
patients in ventricular fibrillation resistant to electrical defibrillationdouble blind
Germany
Li, 1999
Vasopressin, 0.5 U/kg (low dose) or 1.0 U/kg (high dose)
versus
epinephrine

China
Lee, 2000
Vasopressin, 40 U (unknown route)
versus
epinephrine

na
Stiell, 2001
Vasopressin, 40 U IV
versus
epinephrine 1 mg intravenously
adults who had cardiac arrest and required drug therapydouble blind
Canada
Wenzel, 2004
Vasopressin, 40 U IV
versus
epinephrine 1mg IV
adults who had had an out-of-hospital cardiac arrest open
Austria, Germany, Switzerland