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antithrombotics in thrombosis prevention for abdominal surgery, clinical trials results

certoparin versus unfractionated heparin
Schmitz-Huebner, 1984
Certoparin (dose 1 and dose 2) b.i.d.
versus
UFH 10 000 units
Abdominal surgeryBlind
Follow-up duration: 1 month
Sasahara, 1986
Certoparin 3000 + DHE
versus
UFH 10 000 units +DHE
Abdominal surgeryBlind
Follow-up duration: 7 days
Voigt, 1986
Certoparin 3000 + DHE
versus
UFH 10 000 units
Abdominal surgeryBlind
Follow-up duration: 10 days
Welzel, 1988
Certoparin 2500 + DHE
versus
UFH 10 000 units+DHE
Abdominal surgeryOpen
Follow-up duration: 7 days
Kakkar, 1989
Certoparin 3000 + DHE
versus
UFH 10 000 units+DHE
Abdominal surgeryBlind
Adolf, 1989
Certoparin 3000
versus
UFH 15 000 units
Abdominal surgeryBlind
Follow-up duration: 1 month
Baumgartner, 1989
Certoparin 3000 + DHE
versus
UFH 5 000 units+DHE
Abdominal surgeryBlind
Follow-up duration: 10 days
Hoffmann and Largiade, 1990
Certoparin 3000 + DHE
versus
UFH 10 000 units
Abdominal surgeryNA
Koppenhagen, 1990
Certoparin 3000 anti Xa units
versus
UFH 15 000 units
Abdominal surgeryBlind
Schielke, 1991
Certoparin 3000 anti Xa units + DHE
versus
UFH 10 000 units + DHE
Abdominal surgeryOpen
Koppenhagen, 1992
Certoparin 3000 anti Xa units
versus
UFH 15 000 units
Abdominal surgeryBlind
dalteparin versus unfractionated heparin
Bergqvist, 1986
Dalteparin 5000
versus
UFH 10 000 units
Abdominal surgeryBlind
Follow-up duration: 1 month
Onarheim, 1986
Dalteparin 5000
versus
UFH 10 000 units
Abdominal surgeryBlind
Follow-up duration: 1 month
Koller, 1986
Dalteparin 7500
versus
UFH 10 000 units
Abdominal surgeryBlind
Follow-up duration: 30 days
Koller, 1986
Dalteparin 2500
versus
UFH 10 000 units
Abdominal surgeryBlind
Follow-up duration: 30 days
Fricker, 1988
Dalteparin 5000
versus
UFH 15 000 units
Abdominopelvic surgeryOpen
Follow-up duration: 1-2 months
Bergqvist, 1988
Dalteparin 5000
versus
UFH 10 000 units
Abdominal surgeryBlind
Follow-up duration: 1 month
Caen, 1988
Dalteparin 2500
versus
UFH 10 000 units
Abdominal surgeryBlind
Follow-up duration: 1 month
Hartl, 1990
Dalteparin 2500
versus
UFH 10 000 units
Abdominal surgeryBlind
Follow-up duration: > 7 days
Kakkar, 1993
Dalteparin 2500 anti Xa units
versus
UFH 10 000 units
Abdominal surgeryBlind
enoxaparin versus unfractionated heparin
McLeod (Canadian), 1995
Enoxaparin 4000 anti Xa units
versus
UFH 15 000 units
Colorectal surgeryBlind
Gonzalez, 1996
Bemiparin 2500 anti Xa units
versus
UFH 10 000 units
Abdominal surgeryBlind
extended prophylaxis versus standard prophylaxis
Lausen, 1998
Tinzaparin 3500 UI/qd sc for 28 days started in preop
versus
Tinzaparin 3500 UI/qd + GES for 1 week started in preop
>18 years, open major abdominal surgery and non cardiac thoracic surgery of >1hour duration.Open, blinded evaluation
Follow-up duration: 28 days
ENOXACAN II (Bergqvist), 2002
Enoxaparin 40 mg UI/qd sc for 25-31 days started in preop
versus
Enoxaparin 40 mg IU/qd sc for 6 to 10 days (GES optional) started in preop
> 40 years, open major abdominal oncologic elective surgery of >45 minutes duration (includes gynecological surgery)double blind
Follow-up duration: 3 months
FAME (Rasmussen), 2006
Dalteparin 5000 UI/qd SC for 28 days started in preop
versus
Dalteparin 5000 UI/qd SC for 7 days + GES started in preop
> 18 years, major abdominal surgery of >1 hour durationOpen, blinded evaluation
Follow-up duration: 3 months
fondaparinux versus enoxaparin
PEGASUS, 2005
once-daily subcutaneous injections of fondaparinux 2·5 mg started 6 h after surgery for 5–9 days
versus
once-daily subcutaneous injections of dalteparin 5000 units for 5–9 days (2500 units each, given 2 h before surgery and 12 h after the preoperative administration)
patients undergoing major abdominal surgerydouble blind
Follow-up duration: 10 days (30 days)
22 countries
fondaparinux versus placebo (on top intermittent pneumatic comp.)
APOLLO (Turpie), 2007
fondaparinux 2.5 mg s.c. for 5-9 days, starting 6-8 h postoperatively + intermittent pneumatic compression
versus
placebo s.c. for 5-9 days, starting 6-8 h postoperatively + intermittent pneumatic compression
Patients aged at least 40 years undergoing abdominal surgerydouble blind
Follow-up duration: 10 days
US
nadroparin versus unfractionated heparin
EFS, 1988
Nadroparin 2850
versus
UFH 15 000 units
Abdominal surgeryOpen
Follow-up duration: 1 month
parnaparin versus unfractionated heparin
Catania, 1988
Parnaparin 3200
versus
UFH 15 000 units
Abdominal surgeryOpen
Salcuni, 1988
Parnaparin 3200
versus
UFH 15 000 units
Abdominal surgeryOpen
Verardi, 1989
Parnaparin 6400
versus
UFH 10 000 units
Abdominal/urological surgeryNA
Garcea, 1992
Parnaparin 3200 anti Xa units
versus
UFH 15 000 units
Abdominal surgeryOpen

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