DVT prophylaxis - new oral anticoagulant - elective hip replacement clinical trials results meta-analysis

<h1> <a href="index.html"> <strong>DVT prophylaxis</strong> - new oral anticoagulant </a> - elective hip replacement trial results systematic overview and meta-analysis </h1> <h2>Main characteristics of the included studies</h2> <table> <tr> <th>Trial</th> <th>Treatments</th> <th>Patients</th> <th>Methods</th> </tr> <tr> <td> <a href="TRC_t6729.html"> RE-NOVATE (220mg), 2007 </a> <br> NCT00168818 </td> <td> dabigatran etexilate 220 mg q.d. for 28-35 days<br>  <i>versus</i> <br> Enoxaparin 40 mg q.d. </td> <td> Total hip replacement </td> <td> follow-up 28-35 days, median 33d<br> n=1157/1162<br> Parallel groups<br> double blind <br> Europe, Australia, South Africa </td> </tr> <tr> <td> <a href="index.html"> RE-NOVATE (150mg), 2007 </a> <br> NCT00168818 </td> <td> dabigatran etexilate 150 mg q.d. 28-35 days <br>  <i>versus</i> <br> Enoxaparin 40 mg q.d. </td> <td> Total hip replacement </td> <td> follow-up 28-35 days, median 33d<br> n=1174/1162<br> <br> double blind <br> Europe, Australia, South Africa </td> </tr> <tr> <td> <a href="index.html"> BISTRO II (225mg bid), 2005 </a> <br> </td> <td> dabigatran etexilate 225 mg twice daily for 610 days<br>  <i>versus</i> <br> subcutaneous enoxaparin 40 mg once daily </td> <td> patients undergoing total hip or knee replacement </td> <td> follow-up <br> n=393/392<br> Parallel groups<br> double blind <br> Europe and South Africa (2 centres) </td> </tr> <tr> <td> <a href="index.html"> ODIXa-HIP 10mg, 2006 </a> <br> </td> <td> rivaroxaban 10mg daily for 59 days<br>  <i>versus</i> <br> once-daily subcutaneous enoxaparin dose of 40 mg for 59 days </td> <td> patients undergoing elective total hip replacement </td> <td> follow-up 5-9 days<br> n=142/157<br> Parallel groups<br> double blind <br> Europe, Israel </td> </tr> <tr> <td> <a href="index.html"> RECORD 1, 2008 </a> <br> NCT00329628 </td> <td> rivaroxaban 10mg once daily for 35 days<br>  <i>versus</i> <br> enoxaparin 40mg subcutaneous once daily </td> <td> patients undergoing total hip arthroplasty </td> <td> follow-up 36 days (range 30-42)<br> n=2209/2224<br> Parallel groups<br> double blind <br> 27 countries worldwide </td> </tr> <tr> <td> <a href="index.html"> RECORD 2, 2008 </a> <br> NCT00332020 </td> <td> extended thromboprophylaxis with rivaroxaban 10mg once daily for 31-39 days<br>  <i>versus</i> <br> short-term thromboprophylaxis with enoxaparin 40mg subcutaneous once daily for 10-14 days </td> <td> patients undergoing elective total hip replacement </td> <td> follow-up 30-42 days<br> n=1252/1257<br> Parallel groups<br> double blind <br> 21 countries worldwide </td> </tr> <tr> <td> <a href="TRC_t11113.html"> RE-NOVATE 2, 2010 </a> <br> NCT00657150 </td> <td> dabigatran 220mg once daily for 28-35 Days<br>  <i>versus</i> <br> enoxaparin 40mg subcutaneous </td> <td> patients undergoing total hip-replacement surgery </td> <td> follow-up 28-35 days (mean 32d)<br> n=1010/1003<br> Parallel groups<br> double-blind <br> </td> </tr> <tr> <td> <a href="TRC_t10332.html"> CV185-035, </a> <br> NCT00423319 </td> <td> apixaban 2.5mg twice daily 5 weeks<br>  <i>versus</i> <br> enoxaparin 40mg once daily 5 weeks </td> <td> patients undergoing elective total hip replacement surger </td> <td> follow-up 35 days<br> n=5406/0<br> Parallel groups<br> double blind <br> </td> </tr> </table> <h2>References</h2> <p> <b>RE-NOVATE (220mg), 2007 : </b> Eriksson BI, Dahl OE, Rosencher N, Kurth AA, van Dijk CN, Frostick SP, Prins MH, Hettiarachchi R, Hantel S, Schnee J, Büller HRDabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. <i>Lancet 2007;370:949-56</i> [PMID 17869635] </p> <p> <b>RE-NOVATE (150mg), 2007 : </b> Eriksson BI, Dahl OE, Rosencher N, Kurth AA, van Dijk CN, Frostick SP, Prins MH, Hettiarachchi R, Hantel S, Schnee J, Büller HRDabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. <i>Lancet 2007;370:949-56</i> [PMID 17869635] </p> <p> <b>BISTRO II (225mg bid), 2005 : </b> Eriksson BI, Dahl OE, Büller HR, Hettiarachchi R, Rosencher N, Bravo ML, Ahnfelt L, Piovella F, Stangier J, Kälebo P, Reilly PA new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial. <i>J Thromb Haemost 2005 Jan;3:103-11</i> [PMID 15634273] </p> <p> <b>ODIXa-HIP 10mg, 2006 : </b> Eriksson BI, Borris L, Dahl OE, Haas S, Huisman MV, Kakkar AK, Misselwitz F, Kälebo POral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement. <i>J Thromb Haemost 2006 Jan;4:121-8</i> [PMID 16409461] </p> <p> <b>ODIXa-HIP 10mg, 2006 : </b> Eriksson BI, Borris LC, Dahl OE, Haas S, Huisman MV, Kakkar AK, Muehlhofer E, Dierig C, Misselwitz F, Kälebo PA once-daily, oral, direct Factor Xa inhibitor, rivaroxaban (BAY 59-7939), for thromboprophylaxis after total hip replacement. <i>Circulation 2006 Nov 28;114:2374-81</i> [PMID 17116766] </p> <p> <b>RECORD 1, 2008 : </b> Eriksson BI, Borris LC, Friedman RJ, Haas S, Huisman MV, Kakkar AK, Bandel TJ, Beckmann H, Muehlhofer E, Misselwitz F, Geerts WRivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty <i>N Engl J Med 2008;358:2765-75</i> [PMID 18579811] 10.1056/NEJMoa0800374 </p> <p> <b>RECORD 2, 2008 : </b> Kakkar AK, Brenner B, Dahl OE, Eriksson BI, Mouret P, Muntz J, Soglian AG, Pap AF, Misselwitz F, Haas SExtended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. <i>Lancet 2008 Jun 24;:</i> [PMID 18582928] </p>