Trial-Results center  
Clinical trial results database Feedback    Home

Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

pulmonary hypertension - All mecanism - all patients


Related trials

PACES (Simonneau), 2008 - Sildenafil vs Placebo

EARLY (Galie), 2008 - Bosentan vs Placebo

ARIES (Galie=, 2008 - Ambrisentan vs Placebo

COMBI (Hoeper), 2006 - Inhaled iloprost vs Placebo

Singh, 2006 - Sildenafil vs Placebo

STEP (McLaughlin), 2006 - Inhaled iloprost vs Placebo

STRIDE-2 (Barst), 2006 - Sitaxsentan vs Placebo

BREATH-5 (Galie), 2006 - Bosentan vs Placebo

SERAPH (Wilkins), 2005 - Bosentan vs Sildenafil

SUPER-1 (Galie), 2005 - Sildenafil vs Placebo

STRIDE-1 (Barst), 2004 - Sitaxsentan vs Placebo

BREATH-2 (Humbert), 2004 - Epoprostenol + Bosentan vs Epoprostenol + placebo

Sastry, 2004 - Sildenafil vs Placebo

Barst, 2003 - Beraprost vs Placebo

BREATHE-1 (Rubin), 2002 - Bosentan vs Placebo

Langleben, 2002 - Terbogrel vs Placebo

AIR (Olschewski), 2002 - Iloprost vs Placebo

ALPHABET (Galie), 2002 - Beraprost vs Placebo

Simmoneau, 2002 - Treprostinil vs Placebo

Channick, 2001 - Bosentan vs Placebo

Badesch, 2000 - Epoprostenol vs control

Barst, 1996 - Epoprostenol vs control

Rubin, 1990 - Epoprostenol vs control



See also:

  • All pulmonary hypertension clinical trials
  • All clinical trials of All mecanism
  • All clinical trials of Epoprostenol + Bosentan
  •  

    BREATH-2 (Humbert) study, 2004

    Facebook    pdf : Epoprostenol + Bosentan - All mecanism for pulmonary hypertension

    Treatments

    Studied treatment Epoprostenol + Bosentan (62.5 mg b.i.d for 4 weeks then 125 mg b.i.d)
    Control treatment Epoprostenol + placebo

    Patients

    Patients patients with pulmonary arterial hypertension

    Method and design

    Randomized effectives 22 / 11 (studied vs. control)
    Blinding double blind
    Follow-up duration 16 weeks
    Primary endpoint pulmonary vascular resistance


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    All cause death

    3 / 22
    0 / 11
    classic 6,50 [0,12;355,98]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Ref
    Studied treat. Control treat.
    All cause death 3 / 22 (13,6%) 0 / 11 (4,5%) 3,00 [0,16;54,80]   10044 
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 10044: Galiè N, Manes A, Negro L, Palazzini M, Bacchi Reggiani ML, Branzi AEur Heart J 2009;:

  • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.

    Meta-analysis of all similar trials:

    All mecanism in pulmonary hypertension for all patients



    Reference(s)

    Trials register # NA

    (c) 2004-2011 TrialResults-center - All Rights Reserved

    Tweet this  |  notify a friend