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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

pulmonary hypertension - All mecanism - all patients


Related trials

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Sastry, 2004 - Sildenafil vs Placebo

Barst, 2003 - Beraprost vs Placebo

BREATHE-1 (Rubin), 2002 - Bosentan vs Placebo

Langleben, 2002 - Terbogrel vs Placebo

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ALPHABET (Galie), 2002 - Beraprost vs Placebo

Simmoneau, 2002 - Treprostinil vs Placebo

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Badesch, 2000 - Epoprostenol vs control

Barst, 1996 - Epoprostenol vs control

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See also:

  • All pulmonary hypertension clinical trials
  • All clinical trials of All mecanism
  • All clinical trials of Beraprost
  •  

    ALPHABET (Galie) study, 2002

    Facebook    pdf : Beraprost - All mecanism for pulmonary hypertension

    Treatments

    Studied treatment Beraprost
    Control treatment Placebo

    Patients

    Patients patients with pulmonary arterial hypertension NYHA II or III

    Method and design

    Randomized effectives 65 / 65 (studied vs. control)
    Blinding double blind
    Follow-up duration 12 weeks
    Primary endpoint six-minute walk distance


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    All cause death

    1 / 65
    1 / 65
    classic 1,00 [0,06;15,65]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Ref
    Studied treat. Control treat.
    All cause death 1 / 65 (1,5%) 1 / 65 (1,5%) 1,00 [0,06;15,65]   10044 
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 10044: Galiè N, Manes A, Negro L, Palazzini M, Bacchi Reggiani ML, Branzi AEur Heart J 2009;:

  • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    All cause death 1,54% 1,54% 0,0‰

    Meta-analysis of all similar trials:

    All mecanism in pulmonary hypertension for all patients



    Reference(s)

    Trials register # NA
    • Galiè N, Humbert M, Vachiéry JL, Vizza CD, Kneussl M, Manes A, Sitbon O, Torbicki A, Delcroix M, Naeije R, Hoeper M, Chaouat A, Morand S, Besse B, Simonneau G. . J Am Coll Cardiol 2002;39:1496-502
      Pubmed | Hubmed | Fulltext

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