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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

DVT prophylaxis - anticoagulant - orthopedic surgery

DVT prophylaxis - antithrombotics - orthopedic surgery


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See also:

  • All DVT prophylaxis clinical trials
  • All clinical trials of antithrombotics
  • All clinical trials of Acenocoumarol
  •  

    Samama study, 2001

    download pdf: Acenocoumarol | antithrombotics for DVT prophylaxis

    Treatments

    Studied treatment Acenocoumarol
    Control treatment Reviparin 4200 anti-Xa IU x1

    Patients

    Patients THR

    Method and design

    Randomized effectives 645 / 644 (studied vs. control)
    Blinding Open
    Follow-up duration 6 weeks


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    Deep vein thrombosis

    20 / 636
    15 / 643
    classic 1,35 [0,70;2,61]

    Symptomatic pulmonary embolism

    4 / 645
    0 / 644
    classic 16,97 [0,30;957,03]

    Major bleeding

    proximal DVT

    4 / 636
    3 / 643
    classic 1,35 [0,30;6,00]

    All cause death

    2 / 645
    0 / 644
    classic 8,99 [0,14;559,07]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Ref
    Studied treat. Control treat.
    Deep vein thrombosis 20 / 636 (3,1%) 15 / 643 (2,3%) 1,35 [0,70;2,61]
    Symptomatic pulmonary embolism 4 / 645 (0,6%) 0 / 644 (0,1%) 7,99 [0,42;150,79]
    proximal DVT 4 / 636 (0,6%) 3 / 643 (0,5%) 1,35 [0,30;6,00]
    All cause death 2 / 645 (0,3%) 0 / 644 (0,1%) 3,99 [0,18;88,40]
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    Deep vein thrombosis 3,14% 2,33% 8,1‰
    proximal DVT 6,29‰ 4,67‰ 1,6‰

    Meta-analysis of all similar trials:

    anticoagulant in DVT prophylaxis for orthopedic surgery

    antithrombotics in DVT prophylaxis for orthopedic surgery



    Reference(s)

    Trials register # NA
    • Samama CM, Vray M, Barré J, Fiessinger JN, Rosencher N, Lecompte T, Potron G, Basile J, Hull R, Desmichels D. Extended venous thromboembolism prophylaxis after total hip replacement: a comparison of low-molecular-weight heparin with oral anticoagulant.. Arch Intern Med 2002;162:2191-6
      Pubmed | Hubmed | Fulltext

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