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Related trials

ROADMAP, 2010 - olmesartan vs placebo

ADVANCE, 2007 - perindopril and indapamide vs placebo

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IDNT irbesartan, 2001 - Irbesartan vs placebo

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RENAAL, 2001 - losartan vs placebo

IDNT (irbesartan vs amlodipine), 2001 - Irbesartan vs amlodipine

STOP-2 ACEI (diabetic subgroup), 2000 - ACE inhibitor vs diuretic or beta-blocker

STOP-2 (ACEI vs CCB) (diabetic subgroup), 2000 - ACE inhibitor vs CCB

HOPE (diabetic subgroup), 2000 - ACE inhibitor vs placebo

CAPP (diabetic subgroup), 1999 - captopril vs diuretic or beta-blocker

UKPDS 38, 1998 - captopril or atenolol vs control

UKPDS 39, 1998 - captopril vs atenolol

ORIENT, - olmesartan vs placebo

See also:

  • All diabetes clinical trials
  • All clinical trials of anti hypertensive agent
  • All clinical trials of perindopril and indapamide

    ADVANCE study, 2007

    [NCT00145925] Facebook    pdf : perindopril and indapamide - anti hypertensive agent for diabetes


    Studied treatment fixed combination of perindopril and indapamide
    Control treatment placebo
    Concomittant treatment current therapy


    Patients patients with type 2 diabetes irrespective of initial blood pressure levels or the use of other blood pressure lowering drugs

    Method and design

    Randomized effectives NA / NA (studied vs. control)
    Primary endpoint composites of major macrovascular and microvascular events


    No results available for this trial - no clinical endpoint reported

    Meta-analysis of all similar trials:

    angiotensin renin system blockade in diabetes for all type of patients

    angiotensin-receptor blockers in diabetes for all type of patients

    anti hypertensive agent in diabetes for patients with or without hypertension


    Trials register # NCT00145925
    Study web site link ,
    • . Rationale and design of the ADVANCE study: a randomised trial of blood pressure lowering and intensive glucose control in high-risk individuals with type 2 diabetes mellitus. Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation.. J Hypertens Suppl 2001 Nov;19:S21-8
      Pubmed | Hubmed | Fulltext
    • Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee DE, Hamet P, Heller S, Liu LS, Mancia G, Mogensen CE, Pan CY, Rodgers A, Williams B. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial.. Lancet 2007 Sep 8;370:829-40
      Pubmed | Hubmed | Fulltext

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