Main characteristics of the included studies
Trial |
Treatments |
Patients |
Methods |
APIC, 1989
|
Acenocoumarol INR 2-4.5
versus
Placebo
|
AOMI syade II
|
follow-up 1 an
n=72/74
Factorial plan
Simple aveugle
|
De Smit, 1987
|
Phenprocoumon INR 2.8-4.8
versus
Placebo
|
AOMI de stade II (stades III et IV : 7%)
|
follow-up 5 ans
n=155/145
Parallel groups
Double aveugle
|
Calabro, 1993
|
H�parine de bas poids mol�culaire
versus
Placebo
|
AOMI stade II
|
follow-up 6 mois
n=18/18
Parallel groups
Double aveugle
|
Mannarino, 1991
|
H�parine de bas poids mol�culaire( PM= 5000 Dalton), 15000 U od sc
versus
Placebo en seringues pr�remplies de m�me aspect que le traitement
|
AOMI stade II
|
follow-up 6 mois
n=22/22
Parallel groups
Double aveugle
|
Antonicelli, 1999
|
H�parine calcique 12500 IU / j
versus
Placebo
|
AOMI stade II
|
follow-up 3 mois
n=101/100
Parallel groups
Double aveugle
|
Tesi, 1989
|
HBPM 8000 U / j
versus
Placebo
|
AOMI stade II
|
follow-up 6 mois
n=10/10
Parallel groups
Double aveugle
|
CLIPS, 2007
|
oral aspirin 100 mg daily
versus
placebo
|
outpatients with stage I-II PAD documented by angiography or ultrasound, with ankle/brachial index <0.85 or toe index <0.6
|
follow-up 20.7 months mean
n=185/181
Factorial plan
double blind
Europe
|
WAVE, 0
|
versus
|
|
follow-up
n=-9/-9
|
References
APIC, 1989 :
Acenocoumarol and pentoxifylline in intermittent claudication. A controlled clinical study. The APIC Study Group.Dettori AG, Pini M, Moratti A, Paolicelli M, Basevi P, Quintavalla R, Manotti C, Di Lecce C
Angiology 1989 Apr;40:237-48
[PMID 2650578]
De Smit, 1987 :
De Smit P, Van Urk H.Dutch oral anticoagulant trial.
Acta Chir Austriaca 1992; 24:5-7.
[PMID ]
Deutschinoff, 1987 :
Rheological and anticoagulant therapy of patients with chronic peripheral occlusive arterial disease (COAD).Deutschinoff A, Grozdinsky L
Angiology 1987 May;38:351-8
[PMID 3296861]
Calabro, 1993 :
Alessio Calabro, Francesco Piarulli, Daniele Milan,Alberto Rossi, Giovanna CoscettiClinical assessment of low molecular weight heparin . Effects in peripheral vascular disease
angiology 1993;44:188-195
[PMID ]
Mannarino, 1991 :
Mannarino E, Pasqualini L, Innocente S, Orlandi UEfficacy of low molecular weight heparin in the management of intermittent claudication
Angiology 1991;42:1-7
[PMID ]
Allegra , 1994 :
Allegra C, Pollari G, Carioti B, Sardina M.Thrombin and platelet inhibition with low-dose calcium heparin in comparison with ASA in patients with peripheral arterial occlusive disease at Leriche-Fontaine IIb class.
International journal of clinical pharmacology and therapeutics 1994; 32(12):654-651
[PMID ]
Antonicelli, 1999 :
Randomized trial of the effects of low-dose calcium-heparin in patients with peripheral arterial disease and claudication. Italian CAP Study Group.Antonicelli R, Sardina M, Scotti A, Bonizzoni E, Paciaroni E
Am J Med 1999 Sep;107:234-9
[PMID 10492316]
Tesi, 1989 :
[PMID ]
Tesi, 1989 :
Tesi M, Bronchi GF, Carini A, Morfini M, Cinotti S, Filiberti E.Efficacy and safety of a new low molecular weight heparin in the medium- term treatment of atherosclerotic arteriopathy of the lower limbs.
J Drug Dev 1989; 2(2):73-82.
[PMID ]
Andreozzi, 1993 :
Three-month therapy with calcium-heparin in comparison with ticlopidine in patients with peripheral arterial occlusive disease at Leriche-Fontaine IIb class.Andreozzi GM, Signorelli SS, Cacciaguerra G, Di Pino L, Martini R, Monaco S, Butto G, Sardina M
Angiology 1993 Apr;44:307-13
[PMID 8457082]
Serrao, 1991 :
Treatment of peripheral arteriopathies with a new low weight heparin. Results of a double blind, controlled study.Serrao E, Mangialardi N
Panminerva Med 1991 Oct-Dec;33:197-204
[PMID 1806878]
Simoni, 1993 :
Simoni G, Lucertini G, Decian F.Low molecular weight heparins: therapeutic insight in peripheral arterial occlusive disease.
Clinical trials and meta-analysis 1993;28:137-145
[PMID ]
Cina, 1996 :
[Physical training and low-dose heparin-calcium in patients suffering from chronic obliterating arteriopathy of the lower limbs with intermittent claudication]Cina G, Vernich M, Campisi C, Cascone C, Ofria F, Leopardi N, Maniscalco G, Moricca N, Ceccarelli V, Paolicelli D, Carbone D
Minerva Cardioangiol 1996 Apr;44:179-85
[PMID 8767599]
Montesi, 1991 :
Montesi G et alEfficacy of calcium heparin and ASA on long-term therapy of subjects with peripheral obstructive arterial disease
Minerva Cardioangiologica 1991 ;16 (2 suppl 1) 148-50
[PMID ]
Schweizer, 2001 :
Potential use of a low-molecular-weight heparin to prevent restenosis in patients with extensive wall damage following peripheral angioplasty.Schweizer J, Muller A, Forkmann L, Hellner G, Kirch W
Angiology 2001 Oct;52:659-69
[PMID 11666130]
Palmieri, 1988 :
A new low molecular weight heparin in the treatment of peripheral arterial disease.Palmieri G, Ambrosi G, Agrati AM, Ferraro G, Marcozzi S
Int Angiol 1988 Jul-Sep;7:41-7
[PMID 2850326]
WAVE, 0 :
The effects of oral anticoagulants in patients with peripheral arterial disease: rationale, design, and baseline characteristics of the Warfarin and Antiplatelet Vascular Evaluation (WAVE) trial, including a meta-analysis of trials.
Am Heart J 2006 Jan;151:1-9
[PMID 16368284]
CLIPS, 2007 :
Catalano M, Born G, Peto RPrevention of serious vascular events by aspirin amongst patients with peripheral arterial disease: randomized, double-blind trial.
J Intern Med 2007 Mar;261:276-84
[PMID 17305650]