Trial-Results center  
Clinical trial results database in 100 Feedback    Home


Related trials

ARISTOTLE, 2011 - apixaban vs warfarin standard dose

AVERROES, 2011 - apixaban vs aspirin

ROCKET-AF, 2010 - rivaroxaban vs warfarin standard dose

RE-LY (110mg), 2009 - dabigatran 110mg vs warfarin standard dose

ACTIVE A, 2009 - aspirin + clopidogrel vs aspirin

Lip (phase 2 AZD0837), 2009 - AZD0837 vs warfarin standard dose

RE-LY (150mg), 2009 - dabigatran 150mg vs warfarin standard dose

AMADEUS, 2008 - idraparinux vs warfarin standard dose

PETRO (150mg), 2007 - dabigatran 150mg vs warfarin standard dose

ACTIVE W, 2006 - aspirin + clopidogrel vs anticoagulant

Japanese AF Trial, 2006 - aspirin vs control

SPORTIF V, 2005 - ximelagatran vs warfarin standard dose

NASPEAF (triflusal + coumadin medium dose vs coumadin standard dose), 2004 - triflusal+coumadin medium dose vs coumadin standard dose

NASPEAF (triflusal+coumadin medium dose vs triflusal), 2004 - triflusal+coumadin medium dose vs triflusal

NASPEAF (triflusal vs coumadin standard dose)), 2004 - triflusal vs coumadin standard dose

SAFT(warfarin low dose + aspirin vs no treatment), 2003 - warfarin low dose + aspirin vs control

SPORTIF III, 2003 - ximelagatran vs warfarin standard dose

SPORTIF II (ximelagatran vs warfarin standard dose), 2002 - ximelagatran vs warfarin standard dose

PATAF (vs coumadin standard dose), 1999 - aspirin vs coumadin standard dose

LASAF(aspirin vs no treatment), 1999 - aspirin vs control

PATAF (vs coumadin low dose), 1999 - aspirin vs coumadin low dose

PATAF (coumadin low dose vs coumadin standard dose), 1999 - coumadin low dose vs coumadin standard dose

AFASAK II (warfarin low dose+aspirin vs warfarin standard dose), 1998 - warfarin + aspirin vs warfarin standard dose

AFASAK II (aspirin vs warfarin standard dose), 1998 - aspirin vs warfarin standard dose

MWNAF, 1998 - warfarin low dose vs warfarin standard dose



See also:

  • All atrial fibrillation clinical trials
  • All clinical trials of new oral anticoagulants
  • All clinical trials of edoxaban
  •  

    ENGAGE-AF TIMI 48 study,

    [NCT00781391] Ongoing trial download pdf: edoxaban | antithrombotics for atrial fibrillation

    Treatments

    Studied treatment edoxaban 30 or 60mg once daily
    Control treatment warfarin (INR 2-3)

    Patients

    Patients AF patients (CHADS2 >=2)
    Inclusion criteria documented AF within the prior 12 months; moderate to high risk of stroke, as defined by CHADS2 index score of at least 2
    Exclusion criteria Transient atrial fibrillation secondary to other reversible disorders; moderate or severe mitral stenosis, unresected atrial myxoma, or a mechanical heart valve; contraindication for anticoagulant agents; conditions associated with high risk of bleeding; known or suspected hereditary or acquired bleeding disorders

    Method and design

    Randomized effectives NA / NA (studied vs. control)
    Design Parallel groups
    Blinding double blind
    Follow-up duration 24 months
    Primary endpoint stroke, systemic embolic events and all-cause mortality


    Results

    No results available for this trial - ongoing study

    Meta-analysis of all similar trials:

    antithrombotics in atrial fibrillation for primary prevention of thromboembolic events

    direct factor Xa inhibitors in atrial fibrillation for all type of patients

    new oral anticoagulants in atrial fibrillation for all type of patients



    Reference(s)

    Trials register # NCT00781391
    • Ruff CT, Giugliano RP, Antman EM, Crugnale SE, Bocanegra T, Mercuri M, Hanyok J, Patel I, Shi M, Salazar D, McCabe CH, Braunwald E. Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial Infarction study 48 (ENGAGE AF-TIMI 48).. Am Heart J 2010;160:635-41 - 10.1016/j.ahj.2010.06.042
      Pubmed | Hubmed | Fulltext

    (c) 2004-2014 TrialResults-center - All Rights Reserved

    Tweet this  |  Facebook  |  notify a friend

    100100