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Related trials

APPRAISE-1 (10mg od), 2009 - apixaban vs placebo

SEPIA-ACS1 TIMI 42, 2009 - otamixaban vs unfractioned heparin

PLATO, 2009 - ticagrelor + aspirin vs clopidogrel + aspirin

ATLAS ACS-TIMI 46, 2009 - rivaroxaban vs placebo

APPRAISE-1 (2.5 mg bid), 2009 - apixaban vs placebo

DISPERSE-2 (90mg), 2007 - ticagrelor + aspirin vs clopidogrel + aspirin

INTERACT, 2006 - enoxaparin vs UFH (on top of aspirin)

OASIS 5, 2006 - fondaparinux vs enoxaparin

PROTECT-TIMI 30, 2006 - Bivalirudin vs eptifibatide + heparin

SYNERGY, 2005 - enoxaparin vs UFH (on top of aspirin)

EVET, 2005 - enoxaparin vs tinzaparin

LoWASA, 2004 - warfarin vs control (on top of aspirin)

PENTUA, 2004 - fondaparinux vs enoxaparin

Zibaeenezhad, 2004 - warfarin vs control (on top of aspirin)

APRICOT-2, 2002 - warfarin vs control (on top of aspirin)

ASPECT-2 (coumadin+asp vs asp), 2002 - coumadin vs control (on top of aspirin)

WARIS, 2002 - warfarin vs control (on top of aspirin)

ASPECT-2 (coumadin vs aspirin), 2002 - coumadin vs aspirin

CHAMP, 2002 - warfarin vs control (on top of aspirin)

OASIS-2 Warfarin Substudy, 2001 - warfarin vs control (on top of aspirin)

CURE, 2001 - clopidogrel + aspirin vs aspirin

Huyhn, 2001 - warfarin vs placebo (on top of aspirin)

TIM, 2000 - triflusal vs aspirine

HIT-4, 1999 - Hirudin vs heparin

Klootwijk, 1999 - Efegatran vs heparin



See also:

  • All acute coronary syndrome clinical trials
  • All clinical trials of antithrombotics
  • All clinical trials of warfarin
    		•  

    ATACS (pilot study) (warfarin vs control) study, 1990

    Treatments

    Studied treatment heparin/warfarin target INR 3-4.5 + aspirin
    Control treatment aspirin alone
    Concomittant treatment aspirin 325 mg daily

    Patients

    Patients UA, NSTEMI

    Method and design

    Randomized effectives 37 / 32 (studied vs. control)
    Blinding open
    Follow-up duration 3 months
    Lost to follow-up 2.9%


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    all cause death, non-fatal MI, thrombo-embolic stroke

    0 / 37
         1 / 32
         classic 0,17 [0,00;12,35]

    Extracranial hemorrhage

    3 / 37
         3 / 32
         classic 0,86 [0,19;3,99]

    Major bleeding

    3 / 37
         3 / 32
         classic 0,86 [0,19;3,99]

    intracranial hemorrhage

    0 / 37
         0 / 32
         classic 0,86 [0,00;216,66]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    all cause death, non-fatal MI, thrombo-embolic stroke 0 / 37 (1,4%) 1 / 32 (3,1%) 0,43 [0,01;12,47]   8504 
    Extracranial hemorrhage 3 / 37 (8,1%) 3 / 32 (9,4%) 0,86 [0,19;3,99]   8504 
    Major bleeding 3 / 37 (8,1%) 3 / 32 (9,4%) 0,86 [0,19;3,99]   8504 
    intracranial hemorrhage 0 / 37 (1,4%) 0 / 32 (1,6%) 0,86 [0,02;42,36]   8504 
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 8504: Andreotti F, Testa L, Biondi-Zoccai GG, Crea FAspirin plus warfarin compared to aspirin alone after acute coronary syndromes: an updated and comprehensive meta-analysis of 25,307 patients.Eur Heart J 2006;27:519-26
  • 0:

    • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    Extracranial hemorrhage 8,11% 9,38% -12,7‰
    Major bleeding 8,11% 9,38% -12,7‰


    Reference(s)

    Trials register # NA
    • Cohen M, Adams PC, Hawkins L, Bach M, Fuster V. Usefulness of antithrombotic therapy in resting angina pectoris or non-Q-wave myocardial infarction in preventing death and myocardial infarction (a pilot study from the Antithrombotic Therapy in Acute Coronary Syndromes Study Group).. Am J Cardiol 1990;66:1287-92
      Pubmed | Hubmed | Fulltext

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