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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

acute myocardial infarction - myocardial revascularization - all type of patients


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See also:

  • All acute myocardial infarction clinical trials
  • All clinical trials of myocardial revascularization
  • All clinical trials of Prehospital thrombolysis
  •  

    MITI study, 1993

    [NCT00000468] download pdf: Prehospital thrombolysis | myocardial revascularization for acute myocardial infarction

    Treatments

    Studied treatment rt-PA by paramedics
    Control treatment
    Treatments description
    Thrombolytic agent rt-PA 
    Time from sympton onset to thrombolysis median 77/110 min 
    Provider Paramedics 

    Patients

    Inclusion criteria Age <=75 y Suspected AMI with <=6 h of chest pain SBP <180 mm Hg, DBP <120 mm Hg ECG interpretation by physician Physician decision to include, based on interpretation of ECG
    Exclusion criteria Bleeding risks (history of CVA, recent bleeding and/or surgery, known renal/liver disease)

    Method and design

    Randomized effectives 175 / 175 (studied vs. control)
    Blinding ND
    Follow-up duration ND
    Lost to follow-up ND
    Withdrawals (T1/T0) ND /


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    All cause death

    10 / 175
    15 / 175
    0,67 [0,31;1,44]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Ref
    Studied treat. Control treat.
    All cause death 10 / 175 (5,7%) 15 / 175 (8,6%) 0,67 [0,31;1,44]  
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    All cause death 5,71% 8,57% -28,6‰

    Meta-analysis of all similar trials:

    myocardial revascularization in acute myocardial infarction for all type of patients



    Reference(s)

    Trials register # NCT00000468
    • Weaver WD, Cerqueira M, Hallstrom AP, Litwin PE, Martin JS, Kudenchuk PJ, Eisenberg M. Prehospital-initiated vs hospital-initiated thrombolytic therapy. The Myocardial Infarction Triage and Intervention Trial.. JAMA 1993;270:1211-6
      Pubmed | Hubmed | Fulltext

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