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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

cardiovascular prevention - lifestyle intervention - all type of patients

cardiovascular prevention - lifestyle intervention - primary prevention


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See also:

  • All cardiovascular prevention clinical trials
  • All clinical trials of lifestyle intervention
  • All clinical trials of Multiple risk factor interventions
  •  

    MRFIT study, 1982

    [NCT00000487?acronym=] download pdf: Multiple risk factor interventions | lifestyle intervention for cardiovascular prevention

    Treatments

    Studied treatment special intervention (SI) program consisting of stepped-care treatment for hypertension, counseling for cigarette smoking, and dietary advice for lowering blood cholesterol levels
    Control treatment no intervention

    Patients

    Patients high-risk men aged 35 to 57 years
    Baseline characteristics
    Age (yr) 46 y 
    Age range (yr) 35-47 
    interventions Diet, smoking, weight, antihypertensive drugs 

    Method and design

    Randomized effectives 6428 / 6438 (studied vs. control)
    Design Parallel groups
    Blinding open
    Follow-up duration 6 yr
    Remarks Randomisation of individuals


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    All cause death

    265 / 6428
    260 / 6438
    1,02 [0,86;1,21]

    Smoking prevalence

    1847 / 5754
    2554 / 5638
    0,71 [0,68;0,74]

    Coronary death

    115 / 6428
    124 / 6438
    0,93 [0,72;1,19]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Ref
    Studied treat. Control treat.
    All cause death 265 / 6428 (4,1%) 260 / 6438 (4,0%) 1,02 [0,86;1,21]   0
    Smoking prevalence 1847 / 5754 (32,1%) 2554 / 5638 (45,3%) 0,71 [0,68;0,74]  
    Coronary death 115 / 6428 (1,8%) 124 / 6438 (1,9%) 0,93 [0,72;1,19]   0
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 0:
  • 8304: Ketola E, Sipilä R, Mäkelä MEffectiveness of individual lifestyle interventions in reducing cardiovascular disease and risk factors.Ann Med 2000;32:239-51

  • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    All cause death 4,12% 4,04% 0,8‰
    Smoking prevalence 32,10% 45,30% -132,0‰
    Coronary death 1,79% 1,93% -1,4‰

    Meta-analysis of all similar trials:

    lifestyle intervention in cardiovascular prevention for all type of patients

    lifestyle intervention in cardiovascular prevention for primary prevention



    Reference(s)

    Trials register # NCT00000487?acronym=
    • . Mortality rates after 10.5 years for participants in the Multiple Risk Factor Intervention Trial. Findings related to a priori hypotheses of the trial. The Multiple Risk Factor Intervention Trial Research Group.. JAMA 1990;263:1795-801
      Pubmed | Hubmed | Fulltext
    • . Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group.. JAMA 1982;248:1465-77
      Pubmed | Hubmed | Fulltext

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