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See also:

  • All acute myocardial infarction clinical trials
  • All clinical trials of myocardial revascularization
  • All clinical trials of streptokinase
    		•  

    GISSI I study, 1986

    Treatments

    Studied treatment Streptokinase 1.5 MU en perfusion IV en 1 heure
    Control treatment usual care
    Concomittant treatment Toute autre prescription semblant utile aux médecins

    Patients

    Patients patients within 12 h after the onset of symptoms and with no contraindications to SK
    Inclusion criteria Douleur thoracique depuis moins de 12 h, avec sus ou sous-décalage de ST (> ou = 1 mm en dérivations standard, ou > ou = 2 mm en dérivations précordiales)
    Exclusion criteria AVC < 2 mois; chirurgie, geste invasif ou trauma < 10 j; HTA non contrôlée (PAS > ou = 200, PAD > ou = 110 mmHg); antécédent de traitement par streptokinase; pathologie extracardiaque grave; MCE récent; suspicion de thrombus intracardiaque gauche; troubles de l'hémostase; insuffisance rénale ou hépatique sévère; grossesse; rétinopathie diabétique hémorragique

    Method and design

    Randomized effectives 5860 / 5852 (studied vs. control)
    Design Parallel groups
    Blinding open
    Follow-up duration 1 y
    Lost to follow-up 1.6%
    Primary endpoint in hospital death
    Withdrawals (T1/T0) ND /


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    short term death

    628 / 5860
         758 / 5852
         0,83 [0,75;0,91]

    Long term death

    1005 / 5860
         1113 / 5852
         0,90 [0,83;0,97]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    short term death 628 / 5860 (10,7%) 758 / 5852 (13,0%) 0,83 [0,75;0,91]    
    Long term death 1005 / 5860 (17,2%) 1113 / 5852 (19,0%) 0,90 [0,83;0,97]    
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 0:

    • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    short term death 10,72% 12,95% -22,4‰
    Long term death 17,15% 19,02% -18,7‰


    Reference(s)

    Trials register # NA
    • . Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI).. Lancet 1986 Feb 22;1:397-402
      Pubmed | Hubmed | Fulltext
    • . Long-term effects of intravenous thrombolysis in acute myocardial infarction: final report of the GISSI study. Gruppo Italiano per lo Studio della Streptochi-nasi nell'Infarto Miocardico (GISSI).. Lancet 1987 Oct 17;2:871-4
      Pubmed | Hubmed | Fulltext

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