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See also:

  • All acute myocardial infarction clinical trials
  • All clinical trials of myocardial revascularization
  • All clinical trials of streptokinase
    		•  

    Western Washington Intravenous Trial study, 1988

    [NCT00000507]

    Treatments

    Studied treatment Streptokinase en IV, 1.5 M UI en 60 min après injection de benadryl 50 mg en IV et hydrocortisone 100 mg en IV; héparine en IV 1000 UI/h 2h après la streptokinase puis warfarine pendant au moins 3 mois
    Control treatment Traitement standard, avec ou sans anticoagulant (décidé par le médecin)

    Patients

    Patients Hommes et femmes, < ou = 75 ans
    Inclusion criteria IDM < 6 h; douleur thoracique > 20 min; signes ECG (sus-décalage ST dans au moins 2 dérivations, de 1.5 mm en V1, V2, V3 ou 1 mm dans les autres dérivations
    Exclusion criteria Symptomatologie atypique, doute sur l'heure du début; antécédent de traitement par streptokinase; antécédent de pontage aorto-coronarien; contre-indication au traitement anti-coagulant (ulcère actif, rétinopathie diabétique proliférative, PAD > 120 mm HG); manoeuvre chirurgicale < 2 sem, neuro-chirurgicale ou AVC < 4 sem, traumatisme récent, voie veineuse centrale dans une zone incompressible; autre pathologie grave

    Method and design

    Randomized effectives 191 / 177 (studied vs. control)
    Design Parallel groups
    Follow-up duration 1.4 y
    Lost to follow-up ND
    Primary endpoint death at 14 d
    Withdrawals (T1/T0) ND /


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    short term death

    12 / 191
         17 / 177
         0,65 [0,32;1,33]

    Major bleeding

    25 / 191
         1 / 177
         classic 23,17 [3,17;169,20]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    short term death 12 / 191 (6,3%) 17 / 177 (9,6%) 0,65 [0,32;1,33]    
    Major bleeding 25 / 191 (13,1%) 1 / 177 (0,6%) 23,17 [3,17;169,20]    
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 0:

    • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    short term death 6,28% 9,60% -33,2‰
    Major bleeding 13,09% 5,65‰ 12,5%


    Reference(s)

    Trials register # NCT00000507

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