Garcia study - description and results

accelerated t-PA 90 min (15 mg IV bolus followed by an infusion of 0.75 mg/kg over 30min not to exceed 50mg, and then 0.5 mg/kg over the next 60min not to exceed 35mg for a total maximun of 100mg)

Concomittant treatment

aspirin (135-325mg/d) heparin in the angioplasty group: bolus of 10000UI followed by 1000IU/h for 48h, in the t-PA group: 1000UI/h for 38h

Treatments description

Delay from symptoms

Patients

patients with anterior AMI

Inclusion criteria

anterior myocardial infraction, <5h from the onset of pain,

Baseline characteristics

anterior MI	100%
inferior MI	0%
Delay to treatment (PTCA vs thr)	15 min
Diabetes	NA
Previous MI	NA
Killip>=2	NA
Mean EF	NA
% female	NA
mean age	NA

Method and design

Randomized effectives

95 / 94 (studied vs. control)

Design

Parallel groups

Blinding

open

Follow-up duration

30 d

Lost to follow-up

Number of centre

single center

Geographic area

Spain

Hypothesis

Superiority

Withdrawals (T1/T0)

ND /

Reference(s)

Trials register #

García E, Elízaga J, Pérez-Castellano N, Serrano JA, Soriano J, Abeytua M, Botas J, Rubio R, López de Sá E, López-Sendón JL, Delcán JL. Primary angioplasty versus systemic thrombolysis in anterior myocardial infarction.. J Am Coll Cardiol 1999;33:605-11

Pubmed | Hubmed | Fulltext

Garcia study, 1997

Treatments

Patients

Method and design

Results

Reference(s)