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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

pulmonary embolism - fibrinolysis - all type of patients

Related trials

MOPETT, 2012 - half-dose t-PA vs no fibrinolysis

Tebbe, 2009 - desmoteplase vs alteplase

Konstantinides, 2002 - rt-PA vs placebo

Jerjes-Sanchez, 1995 - streptokinase vs no fibrinolysis

Goldhaber, 1993 - rt-PA vs no fibrinolysis

PAIMS 2, 1992 - rt-PA vs no fibrinolysis

Levine, 1990 - rt-PA vs placebo

PIOPED, 1990 - rt-PA vs placebo

Marini, 1988 - urokinase vs no fibrinolysis

Ly, 1978 - streptokinase vs no fibrinolysis

Tibbutt, 1974 - streptokinase vs no fibrinolysis

UPET, 1973 - urokinase vs placebo

See also:

  • All pulmonary embolism clinical trials
  • All clinical trials of fibrinolysis
  • All clinical trials of half-dose t-PA
     MOPETT study, 2012 TRC13277 
    download pdf: half-dose t-PA | fibrinolysis for pulmonary embolism


    Studied treatment half-dose thrombolysis
    half-dose thrombolysis (for those >50 kg, 10 mg in one minute followed by 40 mg in two hours; for those <50 kg, 0.5 mg/kg total dose: 10 mg in one minute followed by the remainder in two hours) and concomitant anticoagulation with around a 20% to 30% reduced dose of enoxaparin or heparin
    Control treatment standard regimen of anticoagulants alone


    Patients patients presenting with moderate PE

    Method and design

    Randomized effectives NA / NA (studied vs. control)
    Design Parallel groups
    Blinding open
    Follow-up duration 28 months
    Number of centre single center
    Primary endpoint Pulmonary hypertension


    No results available for this trial - no clinical endpoint reported

    Meta-analysis of all similar trials:

    fibrinolysis in pulmonary embolism for all type of patients


    TrialResults-center ID TRC13277
    Trials register # NA

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