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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

coronary artery disease - Drug eluting stent - bifurcation lesion


Related trials

Nordic-Baltic Bifurcation Study III, 2009 - kissing balloon vs no kissing balloon

CACTUS , 2009 - double stenting with SES vs single stenting

Ferenc, 2008 - double stenting with SES vs single stenting

BBC ONE, 2008 - double stenting with PES vs single stenting

Pan, 2007 - sirolimus eluting stent vs paclitaxel eluting stent

NORDIC , 2006 - double stenting with SES vs single stenting

Colombo, 2004 - double stenting with SES vs single stenting

Pan, 2004 - double stenting with SES vs single stenting



See also:

  • All coronary artery disease clinical trials
  • All clinical trials of Drug eluting stent
  • All clinical trials of double stenting with SES
  •  

    CACTUS study, 2009

    download pdf: double stenting with SES | Drug eluting stent for coronary artery disease

    Treatments

    Studied treatment elective
    Control treatment stenting of only the main branch, with provisional side-branch T-stenting

    Patients

    Patients patients with true coronary bifurcation lesions
    Baseline characteristics
    Age (y) 66  
    male (%) 78.3 
    diabetes 22.9% 
    hypertension 75.1 
    previous MI (%) 40% 
    prior PCI (%) 28.9 
    prior CABG (%) 5.1 
    LVEF (%) 56 

    Method and design

    Randomized effectives 177 / 173 (studied vs. control)
    Design Parallel groups
    Blinding open
    Follow-up duration 6 months
    Number of centre 12
    Geographic area Europe
    Primary endpoint cardiac death, myocardial infarction, or target-vessel revascularization


    Results

    Endpoint Studied treat.
    n/N
    Control treat.
    n/N
    Graph RR [95% CI]

    myocardial infarction (fatal and non fatal)

    NA / 173
    NA / 177
    classic 1,24 [0,65;2,36]

    target lesion revascularisation

    NA / 173
    NA / 177
    classic 1,16 [0,53;2,52]

    All cause death

    NA / 173
    NA / 177
    classic 0,33 [0,01;9,30]

    Stent thrombosis (any, end of follow up)

    NA / 173
    NA / 177
    classic 1,47 [0,25;8,66]
    0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Ref
    Studied treat. Control treat.
    myocardial infarction (fatal and non fatal) NA / 173 NA / 177 1,24 [0,65;2,36]    
    target lesion revascularisation NA / 173 NA / 177 1,16 [0,53;2,52]    
    All cause death NA / 173 NA / 177 0,33 [0,01;9,30]    
    Stent thrombosis (any, end of follow up) NA / 173 NA / 177 1,47 [0,25;8,66]    
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.

    Meta-analysis of all similar trials:

    Drug eluting stent in coronary artery disease for bifurcation lesion



    Reference(s)

    Trials register # NA
    • Colombo A, Bramucci E, Saccà S, Violini R, Lettieri C, Zanini R, Sheiban I, Paloscia L, Grube E, Schofer J, Bolognese L, Orlandi M, Niccoli G, Latib A, Airoldi F. Randomized study of the crush technique versus provisional side-branch stenting in true coronary bifurcations: the CACTUS (Coronary Bifurcations: Application of the Crushing Technique Using Sirolimus-Eluting Stents) Study.. Circulation 2009;119:71-8 - 10.1161/CIRCULATIONAHA.108.808402
      Pubmed | Hubmed | Fulltext

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