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Related trials

ASTRONOMER, 2010 - rosuvastatin vs placebo

Enhance, 2008 - ezetimibe vs placebo

SEAS, 2008 - ezetimibe+simvastatin vs placebo

SALTIRE, 2005 - atorvastatin vs placebo

PREVEND IT, 2004 - pravastatin vs placebo

ALERT, 2003 - fluvastatin vs placebo



See also:

  • All aortic stenosis clinical trials
  • All cardiovascular prevention clinical trials
  • All clinical trials of cholesterol lowering intervention
  • All clinical trials of atorvastatin
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    SALTIRE study, 2005

    Treatments

    Studied treatment atorvastatin 80mg daily
    Control treatment placebo

    Patients

    Patients patients with calcific aortic stenosis
    Inclusion criteria older than 18 years of age; calcific aortic stenosis; aortic-jet velocity of at least 2.5 m per second; aortic-valve calcification on echocardiography
    Exclusion criteria child-bearing potential without contraception; active or chronic liver disease; history of alcohol or drug abuse; severe mitral-valve stenosis(mitral-valve area, <1 cm2); severe mitral or aortic regurgitation; left ventricular dysfunction (ejection fraction, <35%); planned aortic-valve replacement; intolerance of statins; statin therapy or a potential benefit from statin therapy (according to the treating physician); baseline serum total cholesterol concentration of less than 150 mg per deciliter (4.0 mmol per liter); presence of a permanent pacemaker or cardiodefibrillator

    Method and design

    Randomized effectives 77 / 78 (studied vs. control)
    Design Parallel groups
    Blinding double blind
    Follow-up duration 25 mo (7-36)
    Primary endpoint aortic-jet velocity and aortic-valve calcium score


    Results

    No results available for this trial - no clinical endpoint reported



    Reference(s)

    Trials register # NA
    • Cowell SJ, Newby DE, Prescott RJ, Bloomfield P, Reid J, Northridge DB, Boon NA. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis.. N Engl J Med 2005 Jun 9;352:2389-97
      Pubmed | Hubmed | Fulltext

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