DEFINITE, 2004 trial summary

A randomised clinical trial investigating the effect of ICD versus no ICD in patients with non ischemic cardiomyopathy with EF <0.36 and Nonsustained ventricular tachycardia or frequent premature ventricular complexes

Studied treatment	ICD
Control treatment	no ICD, standard medical therapy
Age (mean), years	58 y
Men (%)	71%
cross over to ICD (%)	NA
cross over to medical treatment (%)	NA

Patients	patients with non ischemic cardiomyopathy with EF <0.36 and Nonsustained ventricular tachycardia or frequent premature ventricular complexes
Group sizes	229 / 229
Ischaemic cause (%)	0%
beta-blocker use (%)	85%
ACE-I or ARB use (%)	86% vs 11%
Spironolactone use (%)
Blinding endpoint comittee	yes
nonischemic cardiomyopathy '%)

Blindness	open	Inclusion period	1998-2000
Follow-up duration	29 months	Centers
Lost to FU		geographical localisation
Primary endpoint	Total mortality	Design	Parallel groups
PeriodeInclusion	1998-2000
duration of CHD	2.8 y

Kadish A, Dyer A, Daubert JP, Quigg R, Estes NA, Anderson KP, Calkins H, Hoch D, Goldberger J, Shalaby A, Sanders WE, Schaechter A, Levine JH Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med 2004;350:2151-8 [PMID: 15152060] link to pdf add to Mendeley

Albert CM, Quigg R, Saba S, Estes NA 3rd, Shaechter A, Subacius H, Howard A, Levine J, Kadish A Sex differences in outcome after implantable cardioverter defibrillator implantation in nonischemic cardiomyopathy. Am Heart J 2008;156:367-72 [PMID: 18657670] link to pdf add to Mendeley

Registering number	(see trial on clinicaltrials.gov)
Code Name

DEFINITE, 2004 trial summary PDF trial summary