MRFIT, 1982 Multiple risk factor interventions versus control

NCT00000487?acronym=   JAMA 1990;263:1795-801  

Multiple risk factor interventions versus control in high-risk men aged 35 to 57 years




Studied treatment special intervention (SI) program consisting of stepped-care treatment for hypertension, counseling for cigarette smoking, and dietary advice for lowering blood cholesterol levels
Control treatment no intervention
Age (yr) 46 y
Age range (yr) 35-47
interventions Diet, smoking, weight, antihypertensive drugs



Patients high-risk men aged 35 to 57 years
Group sizes 6428 / 6438



Blindness open Inclusion period
Follow-up duration 6 yr Centers
Lost to FU geographical localisation
Primary endpoint Design Parallel groups

Randomisation of individuals



EndpointX1N1X0N0TE95% CI SBP - 5740 - 5633 Out of scale-5,30[Non Numérique; Non Numérique] DBP - 5740 - 5633 Out of scale-3,10[Non Numérique; Non Numérique] blood cholesterol concentration - 5743 - 5607 Out of scale-0,13[Non Numérique; Non Numérique] CV events 558 6428 603 6438 0,93[0,82; 1,05] CV death 265 6428 260 6438 1,02[0,86; 1,22] total mortality 265 6428 260 6438 1,02[0,86; 1,22] Coronary heart disease mortality 115 6428 124 6438 0,93[0,72; 1,20] Smoking prevalence 1847 5754 2554 5638 0,71[0,66; 0,76]0,22,01,0


Mortality rates after 10.5 years for participants in the Multiple Risk Factor Intervention Trial. Findings related to a priori hypotheses of the trial. The Multiple Risk Factor Intervention Trial Research Group. JAMA 1990;263:1795-801     [PMID: 2179590]   link to pdf  

 




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