| Trial | Studied treatment | Control treatment | patients | ROB | Result | NCT |
|---|
|
| SU.FOL.OM3 | folic acid, vit B12 and vit B6 | placebo | | | Negative | ISRCTN41926726 |
| CHAOS-2, 2002 | folic acid | placebo | | | Negative | |
| GOES (Liem), 2003 | folic acid | control | | Risk of bias | Negative | |
| FOLARDA (Liem), 2004 | folic acid | control | | Exploratory | Negative | |
| VISP (Toole), 2004 | high dose - folic acid, vit B12 and vit B6 | low dose - folic acid, vit B12 and vit B6 | | Low risk of bias | Negative | |
| NORVIT (folic acid + B12) (Bonaa), 2006 | folic acid, B12 | control | | Low risk of bias | Negative | NCT00266487 |
| NORVIT (folic acid, B12 and vit B6) (Bonaa), 2006 | folic acid, vit B12 and vit B6 | control | | Low risk of bias | Negative | NCT00266487 |
| HOPE-2 (Lonn), 2006 | folic acid, vit B12 and vit B6 | placebo | | Low risk of bias | Suggesting | NCT00106886 |
| SEARCH, 2007 | folic acid, B12 | placebo | | Low risk of bias | Negative | NCT00124072 |
| WAFACS, 2008 | folic acid, vit B12 and vit B6 | placebo | | Low risk of bias | Negative | NCT00000541 |
| WENBIT (folic ac,B12), 2008 | folic acid, B12 | placebo | | Low risk of bias | Negative | NCT00354081 |
| VITATOPS, 2010 | folic acid, vit B12 and vit B6 | placebo | | Low risk of bias | Suggesting | NCT00097669ÐX& |
| CSPPT, 2015 | folic acid | placebo | | Low risk of bias | Suggesting | NCT00794885 |
|
| VISP (Toole), 2004 | high dose - folic acid, vit B12 and vit B6 | low dose - folic acid, vit B12 and vit B6 | | Low risk of bias | Negative | |
| VITATOPS, 2010 | folic acid, vit B12 and vit B6 | placebo | | Low risk of bias | Suggesting | NCT00097669ÐX& |