DVT prophylaxis - antithrombotics - general surgery clinical trials results meta-analysis

<h1> <a href="TM18-8-antithrombotics-DVT prophylaxis" > <strong>DVT prophylaxis</strong> - antithrombotics </a> - general surgery trial results systematic overview and meta-analysis </h1> <h2>Main characteristics of the included studies</h2> <table> <tr> <th>Trial</th> <th>Treatments</th> <th>Patients</th> <th>Methods</th> </tr> <tr> <td> <a href="../TRC_t4156.htm"> Ockelford , 1989 </a> <br> </td> <td> Dalteparin 2500 anti-Xa units<br>  <i>versus</i> <br> Placebo </td> <td> general surgery </td> <td> follow-up <br> n=102/95<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t4157.htm"> Pezzuoli , 1989 </a> <br> </td> <td> Nadroparin 2850 anti-Xa units<br>  <i>versus</i> <br> Placebo </td> <td> general surgery </td> <td> follow-up <br> n=2247/2251<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t4158.htm"> Valle , 1988 </a> <br> </td> <td> Parnaparin 3200 anti-Xa units<br>  <i>versus</i> <br> Placebo </td> <td> general surgery </td> <td> follow-up <br> n=50/50<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7455.htm"> Balas [40], </a> <br> </td> <td> Nadroparin 2850 anti-Xa units<br>  <i>versus</i> <br> Placebo </td> <td> </td> <td> follow-up <br> n=94/95<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7456.htm"> Marassi [41], </a> <br> </td> <td> Nadroparin 2850 anti-Xa units<br>  <i>versus</i> <br> No treatment </td> <td> </td> <td> follow-up <br> n=31/33<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7457.htm"> Bergqvist [42], </a> <br> </td> <td> Tinzaparin 3500 anti-Xa units<br>  <i>versus</i> <br> Placebo </td> <td> </td> <td> follow-up <br> n=39/41<br> Parallel groups<br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7458.htm"> Ho [43], </a> <br> </td> <td> Enoxaparin 4000 anti-Xa units<br>  <i>versus</i> <br> No treatment </td> <td> </td> <td> follow-up <br> n=134/169<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7460.htm"> Schmitz-Huebner, 1984 </a> <br> </td> <td> Certoparin (dose 1 and dose 2) b.i.d.<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up 1 month<br> n=84/42<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7461.htm"> ToÈrngren, 1984 </a> <br> </td> <td> SSHA 50 mg and 37.5 mg<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> General surgery </td> <td> follow-up Discharge<br> n=309/162<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7462.htm"> Kakkar and Murray, 1985 </a> <br> </td> <td> Nadroparin 2850<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> General surgery </td> <td> follow-up 10 days<br> n=200/200<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7463.htm"> Bergqvist, 1986 </a> <br> </td> <td> Dalteparin 5000<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up 1 month<br> n=215/217<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7464.htm"> Onarheim, 1986 </a> <br> </td> <td> Dalteparin 5000<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up 1 month<br> n=25/27<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7465.htm"> Sasahara, 1986 </a> <br> </td> <td> Certoparin 3000 + DHE<br>  <i>versus</i> <br> UFH 10 000 units +DHE </td> <td> Abdominal surgery </td> <td> follow-up 7 days<br> n=137/132<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7466.htm"> Voigt, 1986 </a> <br> </td> <td> Certoparin 3000 + DHE<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up 10 days<br> n=103/97<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7467.htm"> Koller, 1986 </a> <br> </td> <td> Dalteparin 7500<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up 30 days<br> n=23/20<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7468.htm"> Koller, 1986 </a> <br> </td> <td> Dalteparin 2500<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up 30 days<br> n=75/75<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7469.htm"> EFS, 1988 </a> <br> </td> <td> Nadroparin 2850<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominal surgery </td> <td> follow-up 1 month<br> n=968/941<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7470.htm"> Fricker, 1988 </a> <br> </td> <td> Dalteparin 5000<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominopelvic surgery </td> <td> follow-up 1-2 months<br> n=40/40<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7471.htm"> Bergqvist, 1988 </a> <br> </td> <td> Dalteparin 5000<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up 1 month<br> n=505/497<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7472.htm"> Caen, 1988 </a> <br> </td> <td> Dalteparin 2500<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up 1 month<br> n=195/190<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7473.htm"> Borstad, 1988 </a> <br> </td> <td> Dalteparin 5000<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Gynaecological surgery </td> <td> follow-up <br> n=105/110<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7474.htm"> Samama 1, 1988 </a> <br> </td> <td> Enoxaparin 2000<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> General surgery </td> <td> follow-up 7 days<br> n=168/167<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7475.htm"> Samama 2, 1988 </a> <br> </td> <td> Enoxaparin 4000<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> General surgery </td> <td> follow-up 7 days<br> n=127/123<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7476.htm"> Samama 3, 1988 </a> <br> </td> <td> Enoxaparin 6000<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> General surgery </td> <td> follow-up 7 days<br> n=160/147<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7477.htm"> Welzel, 1988 </a> <br> </td> <td> Certoparin 2500 + DHE<br>  <i>versus</i> <br> UFH 10 000 units+DHE </td> <td> Abdominal surgery </td> <td> follow-up 7 days<br> n=98/103<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7478.htm"> Briel, 1988 </a> <br> </td> <td> Dalteparin 5000<br>  <i>versus</i> <br> UFH 10 000 units+DHE </td> <td> Gynaecological surgery </td> <td> follow-up <br> n=95/98<br> <br> NA <br> </td> </tr> <tr> <td> <a href="../TRC_t7479.htm"> Catania, 1988 </a> <br> </td> <td> Parnaparin 3200<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominal surgery </td> <td> follow-up <br> n=88/85<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7481.htm"> Salcuni, 1988 </a> <br> </td> <td> Parnaparin 3200<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominal surgery </td> <td> follow-up <br> n=73/68<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7482.htm"> Kakkar, 1989 </a> <br> </td> <td> Certoparin 3000 + DHE<br>  <i>versus</i> <br> UFH 10 000 units+DHE </td> <td> Abdominal surgery </td> <td> follow-up <br> n=88/91<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7483.htm"> Adolf, 1989 </a> <br> </td> <td> Certoparin 3000<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominal surgery </td> <td> follow-up 1 month<br> n=205/205<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7484.htm"> Heilmann, 1989 </a> <br> </td> <td> Certoparin 3000<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Gynaecological surgery </td> <td> follow-up 10 days<br> n=150/150<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7485.htm"> Baumgartner, 1989 </a> <br> </td> <td> Certoparin 3000 + DHE<br>  <i>versus</i> <br> UFH 5 000 units+DHE </td> <td> Abdominal surgery </td> <td> follow-up 10 days<br> n=99/102<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7486.htm"> Dahan, 1989 </a> <br> </td> <td> Nadroparin 2850<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Thoracic surgery </td> <td> follow-up <br> n=46/41<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7487.htm"> Verardi, 1989 </a> <br> </td> <td> Parnaparin 6400<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal/urological surgery </td> <td> follow-up <br> n=44/44<br> <br> NA <br> </td> </tr> <tr> <td> <a href="../TRC_t7488.htm"> Creperio, 1990 </a> <br> </td> <td> Dalteparin 2500<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> General surgery </td> <td> follow-up <br> n=20/20<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7489.htm"> Hartl, 1990 </a> <br> </td> <td> Dalteparin 2500<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up > 7 days<br> n=126/124<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7490.htm"> Hoffmann and Largiade, 1990 </a> <br> </td> <td> Certoparin 3000 + DHE<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up <br> n=464/452<br> <br> NA <br> </td> </tr> <tr> <td> <a href="../TRC_t7491.htm"> Koppenhagen, 1990 </a> <br> </td> <td> Certoparin 3000 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominal surgery </td> <td> follow-up <br> n=51/53<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7492.htm"> Barbui, 1990 </a> <br> </td> <td> Nadroparin 2850 anti Xa units<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> General surgery </td> <td> follow-up <br> n=171/173<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7493.htm"> Leizorovicz, 1991 </a> <br> </td> <td> Tinzaparin 2500 and 3500 anti Xa units<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominothoracic and gynaecological surgery </td> <td> follow-up <br> n=861/429<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7494.htm"> Schielke, 1991 </a> <br> </td> <td> Certoparin 3000 anti Xa units + DHE<br>  <i>versus</i> <br> UFH 10 000 units + DHE </td> <td> Abdominal surgery </td> <td> follow-up <br> n=47/51<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7495.htm"> Kaaja, 1992 </a> <br> </td> <td> Enoxaparin 2000 anti Xa units<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Gynaecological surgery </td> <td> follow-up <br> n=37/31<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7496.htm"> Koppenhagen, 1992 </a> <br> </td> <td> Certoparin 3000 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominal surgery </td> <td> follow-up <br> n=336/337<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7497.htm"> Borstad, 1992 </a> <br> </td> <td> Dalteparin 2500 anti Xa units<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Gynaecological surgery </td> <td> follow-up <br> n=77/75<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7498.htm"> Hoffmann and Largiader, 1992 </a> <br> </td> <td> Certoparin 3000 anti Xa units<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominothoracic surgery </td> <td> follow-up <br> n=298/296<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7499.htm"> Garcea, 1992 </a> <br> </td> <td> Parnaparin 3200 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominal surgery </td> <td> follow-up <br> n=45/45<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7500.htm"> Kakkar, 1993 </a> <br> </td> <td> Reviparin 1750 anti Xa units<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> General and gynaecological surgery </td> <td> follow-up <br> n=672/679<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7501.htm"> Kakkar, 1993 </a> <br> </td> <td> Dalteparin 2500 anti Xa units<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up <br> n=1894/1915<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7502.htm"> Godwin, 1993 </a> <br> </td> <td> Ardeparin 90 and 50 units/kg b.i.d<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominopelvic surgery </td> <td> follow-up <br> n=595/309<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7503.htm"> Gazzaniga (ISG), 1993 </a> <br> </td> <td> Enoxaparin 2000 anti Xa units<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> General and vascular surgery </td> <td> follow-up <br> n=561/561<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7504.htm"> Limmer, 1994 </a> <br> </td> <td> Antixarin 2500 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> General surgery </td> <td> follow-up <br> n=103/100<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7505.htm"> Eurin, 1994 </a> <br> </td> <td> Nadroparin 2850 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominopelvic surgery </td> <td> follow-up <br> n=241/239<br> <br> Open <br> </td> </tr> <tr> <td> <a href="../TRC_t7506.htm"> Nurmohamed, 1995 </a> <br> </td> <td> Enoxaparin 2000 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> General surgery </td> <td> follow-up <br> n=737/734<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7507.htm"> McLeod (Canadian), 1995 </a> <br> </td> <td> Enoxaparin 4000 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Colorectal surgery </td> <td> follow-up <br> n=674/675<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7508.htm"> Gonzalez, 1996 </a> <br> </td> <td> Bemiparin 2500 anti Xa units<br>  <i>versus</i> <br> UFH 10 000 units </td> <td> Abdominal surgery </td> <td> follow-up <br> n=84/82<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7509.htm"> ENOXACAN, 1997 </a> <br> </td> <td> Enoxaparin 4000 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Abdominopelvic surgery </td> <td> follow-up <br> n=555/560<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7510.htm"> Heilmann, 1997 </a> <br> </td> <td> Certoparin 3000 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> Gynaecological and breast surgery </td> <td> follow-up <br> n=179/179<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7511.htm"> Haas, 1999 </a> <br> </td> <td> Certoparin 3000 anti Xa units<br>  <i>versus</i> <br> UFH 15 000 units </td> <td> General surgery </td> <td> follow-up <br> n=11542/11536<br> <br> Blind <br> </td> </tr> <tr> <td> <a href="../TRC_t7533.htm"> Kakkar (IMT), 0 </a> <br> </td> <td> UFH 3 times daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> All other general surgery </td> <td> follow-up <br> n=2111/2137<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7534.htm"> Gruber, 0 </a> <br> </td> <td> UFH 3 times daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> All other general surgery </td> <td> follow-up <br> n=119/113<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7535.htm"> Kakkar, 1972 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> placebo </td> <td> All other general surgery </td> <td> follow-up <br> n=39/39<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7536.htm"> Kiil, 1978 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> placebo </td> <td> All other general surgery </td> <td> follow-up <br> n=650/663<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7537.htm"> Torngren, 1978 </a> <br> </td> <td> UFH twice daily for 6-8 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=66/62<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7538.htm"> Torngren, 0 </a> <br> </td> <td> UFH twice daily for 6-8 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=47/62<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7539.htm"> Lahnborg, 1975 </a> <br> </td> <td> UFH twice daily for 5 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=58/54<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7540.htm"> Lahnborg, 1976 </a> <br> </td> <td> UFH twice daily for 5 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=24/24<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7541.htm"> Covey, 1975 </a> <br> </td> <td> UFH twice daily for 8 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=53/52<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7542.htm"> Belch, 1980 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=24/25<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7543.htm"> Taberner, 1978 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=50/50<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7544.htm"> Strand, 1975 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=55/55<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7545.htm"> Roberts, 1975 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=39/45<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7546.htm"> Ribaudo, 1975 </a> <br> </td> <td> UFH twice daily for A days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=75/75<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7547.htm"> Wu, 1977 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=44/44<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7548.htm"> Lawrence, 1977 </a> <br> </td> <td> UFH twice daily for 5 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=133/129<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7549.htm"> Muiticentre, 1984 </a> <br> </td> <td> UFH twice daily for 5-7 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=222/108<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7550.htm"> Muiticentre 53,S4, 1984 </a> <br> </td> <td> UFH twice daily for 5-7 days<br>  <i>versus</i> <br> DHE </td> <td> all other general surgery </td> <td> follow-up <br> n=214/110<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7551.htm"> Muiticentre, 1984 </a> <br> </td> <td> UFH twice daily for 5-7 days<br>  <i>versus</i> <br> DHE </td> <td> all other general surgery </td> <td> follow-up <br> n=226/110<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7552.htm"> Jourdan, 1984 </a> <br> </td> <td> UFH twice daily for 5 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=21/21<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7553.htm"> van Geloven, 1977 </a> <br> </td> <td> UFH twice daily for 4 days<br>  <i>versus</i> <br> Oral anticoagulant </td> <td> all other general surgery </td> <td> follow-up <br> n=74/80<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7554.htm"> Loew, 1977 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> aspirin </td> <td> all other general surgery </td> <td> follow-up <br> n=60/67<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7555.htm"> Vinazzer, 1980 </a> <br> </td> <td> UFH twice daily for A days<br>  <i>versus</i> <br> aspirin </td> <td> all other general surgery </td> <td> follow-up <br> n=402/404<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7556.htm"> Gordon-Smith, 1972 </a> <br> </td> <td> UFH twice daily for 5 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=-9/51<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7557.htm"> Nicolaides, 1972 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=128/122<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7558.htm"> Multiunit, 1974 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=128/128<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7559.htm"> Abernethy, 1974 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=63/62<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7560.htm"> Clarke-Pearson, 1983 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=95/105<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7561.htm"> Plante, 1979 </a> <br> </td> <td> UFH twice daily for 8 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=42/66<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7562.htm"> Abraham-Inpijn, 1979 </a> <br> </td> <td> UFH twice daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=20/20<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7563.htm"> Spebar, 1981 </a> <br> </td> <td> UFH twice daily for 5-7 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=24/19<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7564.htm"> Sagar, 1974 </a> <br> </td> <td> UFH twice daily for 5 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=264/236<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7565.htm"> Koppenhagen, 1982 </a> <br> </td> <td> UFH twice daily<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=162/50<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7566.htm"> Bergqvist, 1980 </a> <br> </td> <td> UFH twice daily for 5 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=53/58<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7567.htm"> Torngren, 1978 </a> <br> </td> <td> UFH 3 times daily for 6-8 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=10/10<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7568.htm"> Kruse-Blinkenberg, 1980 </a> <br> </td> <td> UFH 3 times daily for 8 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=29/33<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7569.htm"> Kraytman, 1977 </a> <br> </td> <td> UFH 3 times daily for 6 days<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=25/22<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7570.htm"> Marchetti, 1982 </a> <br> </td> <td> UFH 3 times daily<br>  <i>versus</i> <br> placebo </td> <td> all other general surgery </td> <td> follow-up <br> n=16/13<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7571.htm"> Gallus, 1973 </a> <br> </td> <td> UFH 3 times daily for A<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=100/109<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7572.htm"> Gallus, 1976 </a> <br> </td> <td> UFH 3 times daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=408/412<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7573.htm"> Groote Schuur, 1979 </a> <br> </td> <td> UFH 3 times daily for 6 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=323/323<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7574.htm"> Kraytman, 1976 </a> <br> </td> <td> UFH 3 times daily for 6 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=21/28<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7575.htm"> Kraytman, 1977 </a> <br> </td> <td> UFH 3 times daily for 6 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=23/27<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7576.htm"> Kettunen, 1974 </a> <br> </td> <td> UFH 3 times daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=83/117<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7577.htm"> Caloghera, 1984 </a> <br> </td> <td> UFH 3 times daily for 7 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=40/40<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7578.htm"> Marchelli, 1983 </a> <br> </td> <td> UFH 3 times daily for ?<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=30/30<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t7579.htm"> Ziemski, 1979 </a> <br> </td> <td> UFH 3 times daily for 2 days<br>  <i>versus</i> <br> no treatment </td> <td> all other general surgery </td> <td> follow-up <br> n=30/20<br> <br> <br> </td> </tr> </table> <h2>References</h2> <p> <b>Ockelford , 1989 : </b> Ockelford PA, Patterson J, Johns ASA double-blind randomized placebo controlled trial of thromboprophylaxis in major elective general surgery using once daily injections of a low molecular weight heparin fragment (Fragmin). <i>Thromb Haemost 1989;62:1046-9</i> [PMID 2559484] </p> <p> <b>Pezzuoli , 1989 : </b> Pezzuoli G, Neri Serneri GG, Settembrini P, Coggi G, Olivari N, Buzzetti G, Chierichetti S, Scotti A, Scatigna M, Carnovali MProphylaxis of fatal pulmonary embolism in general surgery using low-molecular weight heparin Cy 216: a multicentre, double-blind, randomized, controlled, clinical trial versus placebo (STEP). 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