DVT prophylaxis - direct factor Xa inhibitors - all type of patients clinical trials results meta-analysis

<h1> <a href="TM18-131-direct factor Xa inhibitors-DVT prophylaxis" > <strong>DVT prophylaxis</strong> - direct factor Xa inhibitors </a> - all type of patients trial results systematic overview and meta-analysis </h1> <h2>Main characteristics of the included studies</h2> <table> <tr> <th>Trial</th> <th>Treatments</th> <th>Patients</th> <th>Methods</th> </tr> <tr> <td> <a href="../TRC_t7224.htm"> ODIXa-HIP 10mg, 2006 </a> <br> </td> <td> rivaroxaban 10mg daily for 5–9 days<br>  <i>versus</i> <br> once-daily subcutaneous enoxaparin dose of 40 mg for 5–9 days </td> <td> patients undergoing elective total hip replacement </td> <td> follow-up 5-9 days<br> n=142/157<br> Parallel groups<br> double blind <br> Europe, Israel </td> </tr> <tr> <td> <a href="../TRC_t7225.htm"> ODIXa-KNEE, 2005 </a> <br> </td> <td> BAY 59-7939 5mg b.i.d. for 5–9 days<br>  <i>versus</i> <br> enoxaparin 30 mg b.i.d. for 5–9 days </td> <td> patients undergoing elective total knee replacement </td> <td> follow-up 5-9 days<br> n=102/105<br> Parallel groups<br> double blind <br> North America </td> </tr> <tr> <td> <a href="../TRC_t7330.htm"> RECORD 1, 2008 </a> <br> NCT00329628 </td> <td> rivaroxaban 10mg once daily for 35 days<br>  <i>versus</i> <br> enoxaparin 40mg subcutaneous once daily </td> <td> patients undergoing total hip arthroplasty </td> <td> follow-up 36 days (range 30-42)<br> n=2209/2224<br> Parallel groups<br> double blind <br> 27 countries worldwide </td> </tr> <tr> <td> <a href="../TRC_t7331.htm"> RECORD 2, 2008 </a> <br> NCT00332020 </td> <td> extended thromboprophylaxis with rivaroxaban 10mg once daily for 31-39 days<br>  <i>versus</i> <br> short-term thromboprophylaxis with enoxaparin 40mg subcutaneous once daily for 10-14 days </td> <td> patients undergoing elective total hip replacement </td> <td> follow-up 30-42 days<br> n=1252/1257<br> Parallel groups<br> double blind <br> 21 countries worldwide </td> </tr> <tr> <td> <a href="../TRC_t7332.htm"> RECORD 3, 2008 </a> <br> NCT00361894 </td> <td> rivaroxaban 10 mg once daily for 10- 14 days<br>  <i>versus</i> <br> enoxaparin 40 mg subcutaneous once daily </td> <td> patients undergoing total knee arthroplasty </td> <td> follow-up 13-17 days<br> n=1254/1277<br> Parallel groups<br> double blind <br> 19 countries worldwide </td> </tr> <tr> <td> <a href="../TRC_t7333.htm"> RECORD 4, 2009 </a> <br> NCT00362232 </td> <td> rivaroxaban 10mg once daily for 10 to 14 days<br>  <i>versus</i> <br> enoxaparin 30 mg twice daily by subcutaneous injection for 10 to 14 days </td> <td> patients who had undergone total-knee-replacement surgery </td> <td> follow-up 40 days<br> n=1584/1564<br> Parallel groups<br> double blind <br> 12 countries </td> </tr> <tr> <td> <a href="../TRC_t8585.htm"> ADVANCE-1, 2008 </a> <br> NCT00371683 </td> <td> apixaban 2.5 mg orally twice daily for 10 to 14 days<br>  <i>versus</i> <br> enoxaparin 30mg subcutaneously every 12 hours </td> <td> patients undergoing knee-replacement surgery </td> <td> follow-up 10-14 days<br> n=1599/1596<br> Parallel groups<br> double blind <br> 14 countries </td> </tr> <tr> <td> <a href="../TRC_t10333.htm"> ADVANCE 2 (CV185-047), 2010 </a> <br> NCT00452530 </td> <td> apixaban 2.5mg twice daily during 12 days<br>  <i>versus</i> <br> enoxaparin 40mg once daily 12 days </td> <td> patients undergoing elective unilateral or bilateral total knee replacement </td> <td> follow-up 12 days<br> n=1528/1529<br> Parallel groups<br> double blind <br> 27 countries </td> </tr> <tr> <td> <a href="../TRC_t7226.htm"> CV185-010, 2007 </a> <br> NCT00097357 </td> <td> apixaban 2.5mg BID, 5mg BID, 10mg BID, 5mgQD, 20mg QD for 12 days<br>  <i>versus</i> <br> enoxaparin 30mg twice daily for 12 days </td> <td> patients undergoing elective total knee replacement surgery </td> <td> follow-up 12 days<br> n=-9/-9<br> Parallel groups<br> double blind <br> </td> </tr> <tr> <td> <a href="../TRC_t10330.htm"> CV185-036, </a> <br> NCT00457002 </td> <td> apixaban 2.5mg twice daily, 30 days<br>  <i>versus</i> <br> enoxaparin 40mg once daily 6-14 days </td> <td> Acutely ill medical patienst during and following hospitalization </td> <td> follow-up 30 days<br> n=6524/0<br> Parallel groups<br> double blind <br> </td> </tr> <tr> <td> <a href="../TRC_t10332.htm"> CV185-035, </a> <br> NCT00423319 </td> <td> apixaban 2.5mg twice daily 5 weeks<br>  <i>versus</i> <br> enoxaparin 40mg once daily 5 weeks </td> <td> patients undergoing elective total hip replacement surger </td> <td> follow-up 35 days<br> n=5406/0<br> Parallel groups<br> double blind <br> </td> </tr> </table> <h2>References</h2> <p> <b>ODIXa-HIP 10mg, 2006 : </b> Eriksson BI, Borris L, Dahl OE, Haas S, Huisman MV, Kakkar AK, Misselwitz F, Kälebo POral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement. <i>J Thromb Haemost 2006 Jan;4:121-8</i> [PMID 16409461] </p> <p> <b>ODIXa-HIP 10mg, 2006 : </b> Eriksson BI, Borris LC, Dahl OE, Haas S, Huisman MV, Kakkar AK, Muehlhofer E, Dierig C, Misselwitz F, Kälebo PA once-daily, oral, direct Factor Xa inhibitor, rivaroxaban (BAY 59-7939), for thromboprophylaxis after total hip replacement. <i>Circulation 2006 Nov 28;114:2374-81</i> [PMID 17116766] </p> <p> <b>ODIXa-KNEE, 2005 : </b> Turpie AG, Fisher WD, Bauer KA, Kwong LM, Irwin MW, Kälebo P, Misselwitz F, Gent MBAY 59-7939: an oral, direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study. <i>J Thromb Haemost 2005 Nov;3:2479-86</i> [PMID 16241946] </p> <p> <b>CV185-010, 2007 : </b> Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman DThe efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. <i>J Thromb Haemost 2007 Dec;5:2368-75</i> [PMID 17868430] </p> <p> <b>RECORD 1, 2008 : </b> Eriksson BI, Borris LC, Friedman RJ, Haas S, Huisman MV, Kakkar AK, Bandel TJ, Beckmann H, Muehlhofer E, Misselwitz F, Geerts WRivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty <i>N Engl J Med 2008;358:2765-75</i> [PMID 18579811] 10.1056/NEJMoa0800374 </p> <p> <b>RECORD 2, 2008 : </b> Kakkar AK, Brenner B, Dahl OE, Eriksson BI, Mouret P, Muntz J, Soglian AG, Pap AF, Misselwitz F, Haas SExtended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. <i>Lancet 2008 Jun 24;:</i> [PMID 18582928] </p> <p> <b>RECORD 3, 2008 : </b> Lassen MR, Ageno W, Borris LC, Lieberman JR, Rosencher N, Bandel TJ, Misselwitz F, Turpie AGRivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. <i>N Engl J Med 2008 Jun 26;358:2776-86</i> [PMID 18579812] </p> <p> <b>RECORD 4, 2009 : </b> Turpie AG, Lassen MR, Davidson BL, Bauer KA, Gent M, Kwong LM, Cushner FD, Lotke PA, Berkowitz SD, Bandel TJ, Benson A, Misselwitz F, Fisher WDRivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. <i>Lancet 2009;:</i> [PMID 19411100] </p> <p> <b>ADVANCE-1, 2008 : </b> Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Portman RJApixaban or enoxaparin for thromboprophylaxis after knee replacement. <i>N Engl J Med 2009;361:594-604</i> [PMID 19657123] </p> <p> <b>CV185-034, : </b> Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Portman RJApixaban or enoxaparin for thromboprophylaxis after knee replacement. <i>N Engl J Med 2009;361:594-604</i> [PMID 19657123] </p> <p> <b>ADVANCE 2 (CV185-047), 2010 : </b> Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Hornick PApixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial. <i>Lancet 2010 Mar 6;375:807-15</i> [PMID 20206776] 10.1016/S0140-6736(09)62125-5 </p>