acute myocardial infarction - cell-based therapies - PCI clinical trials results meta-analysis

<h1> <a href="TM1-98-cell-based therapies -acute myocardial infarction" > <strong>acute myocardial infarction</strong> - cell-based therapies </a> - PCI trial results systematic overview and meta-analysis </h1> <h2>Main characteristics of the included studies</h2> <table> <tr> <th>Trial</th> <th>Treatments</th> <th>Patients</th> <th>Methods</th> </tr> <tr> <td> <a href="../TRC_t9508.htm"> REVIVAL-2 (Zohlnhöfer ), 2006 </a> <br> NCT00126100 </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> placebo </td> <td> patients with acute myocardial infarction after successful mechanical reperfusion reduces infarct size </td> <td> follow-up 6 months<br> n=56/58<br> Parallel groups<br> double blind <br> Germany </td> </tr> <tr> <td> <a href="../TRC_t9509.htm"> STEMMI (Ripa), 2006 </a> <br> </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> placebo </td> <td> patients with ST-elevation myocardial infarction </td> <td> follow-up 6 months<br> n=39/39<br> <br> double blind <br> </td> </tr> <tr> <td> <a href="../TRC_t9510.htm"> G-CSF-STEMI (Engelmann), 2006 </a> <br> </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> placebo </td> <td> patients with late revascularized subacute STEMI </td> <td> follow-up 3 months<br> n=23/21<br> <br> double blind <br> germany </td> </tr> <tr> <td> <a href="../TRC_t9511.htm"> FIRSTLINE-AMI (Ince), 2005 </a> <br> </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> usual care </td> <td> patients with ST-elevation myocardial infarction undergoing primary PCI with stenting and abciximab </td> <td> follow-up 4 months (1y)<br> n=25/25<br> <br> open <br> germany </td> </tr> <tr> <td> <a href="../TRC_t9512.htm"> MAGIC Cell-3-DES (Kang), 2006 </a> <br> </td> <td> peripheral blood stem cells mobilized by G-CSF for 3 days and delivered to infarcted myocardium via intracoronary infusion<br>  <i>versus</i> <br> control </td> <td> patients with recent or old myocardial infarction who underwent coronary revascularization with DES </td> <td> follow-up 6 months<br> n=27/29<br> <br> open <br> Korea </td> </tr> <tr> <td> <a href="../TRC_t9513.htm"> MAGIC (G-CSF) (Kang), 2004 </a> <br> </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> control </td> <td> patients with myocardial infarction who underwent coronary stenting for the culprit lesion of infarction </td> <td> follow-up 6 montsh<br> n=10/7<br> <br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9514.htm"> MAGIC 1 (Kang), 2007 </a> <br> </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> control </td> <td> patients with myocardial infarction </td> <td> follow-up 24 months<br> n=-9/-9<br> <br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9515.htm"> Valgimigli, 2005 </a> <br> </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> placebo </td> <td> patients with STEMI </td> <td> follow-up 6 months<br> n=10/10<br> <br> double blind <br> Italy </td> </tr> <tr> <td> <a href="../TRC_t9516.htm"> Ellis, 2006 </a> <br> NCT00215124 </td> <td> granulocyte colony stimulating factor (G-CSF) at 5 escalating to 10 microg/kg per day subcutaneously for 5 days<br>  <i>versus</i> <br> placebo </td> <td> patients with large acute myocardial infarction </td> <td> follow-up 1 months<br> n=18/0<br> <br> double blind <br> </td> </tr> <tr> <td> <a href="../TRC_t9517.htm"> Takano, 2007 </a> <br> </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> control </td> <td> patients with AMI related with the left anterior descending coronary artery, who underwent successful percutaneous coronary intervention </td> <td> follow-up 6 months<br> n=18/22<br> <br> open <br> Japan </td> </tr> <tr> <td> <a href="../TRC_t9518.htm"> RIGENERA (Leone), 2007 </a> <br> </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> control </td> <td> patients with large anterior wall AMI at high risk of unfavorable remodeling and with successful primary or rescue percutaneous coronary intervention and LVEF<50% </td> <td> follow-up 5 months<br> n=-9/-9<br> <br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9519.htm"> Suarez de Lezo (G-CSF), 2007 </a> <br> </td> <td> systemic administration of granulocyte colony-stimulating factor (G-CSF)<br>  <i>versus</i> <br> control </td> <td> patients with revascularized anterior wall AMI and depressed left ventricular function (ejection fraction < 45%) </td> <td> follow-up 3 months<br> n=10/10<br> <br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9707.htm"> MAGIC (cell infusion ), 2004 </a> <br> </td> <td> intracoronary infusion of collected peripheral blood stem-cells<br>  <i>versus</i> <br> control </td> <td> patients with myocardial infarction who underwent coronary stenting for the culprit lesion of infarction </td> <td> follow-up <br> n=10/7<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t9708.htm"> Suarez de Lezo (cell), 2007 </a> <br> </td> <td> intracoronary infusion of autologous mononuclear bone marrow cells (9 10^8)<br>  <i>versus</i> <br> control (Saline containing 0.1% heparin) </td> <td> patients with revascularized anterior wall AMI and depressed left ventricular function (ejection fraction < 45%) </td> <td> follow-up 3 months<br> n=10/10<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9711.htm"> TCT-STAMI (Ge), 2006 </a> <br> </td> <td> emergent intracoronary autologous bone marrow cell transplantation (4 10^7 SC)<br>  <i>versus</i> <br> control </td> <td> patients admitted within 24 h after the onset of a first AMI </td> <td> follow-up 6 months<br> n=10/10<br> parallel group<br> NA <br> </td> </tr> <tr> <td> <a href="../TRC_t9712.htm"> Huang, 2006 </a> <br> </td> <td> intracoronary transplantation of autologous BM-MNC via a micro-catheter right after PCI (stem cells mean 1.8 10^8)<br>  <i>versus</i> <br> placebo (Heparanised saline) </td> <td> patients with first onset of acute inferior-wall myocardial infarction aged < or = 75, treated with emergent percutaneous coronary intervention </td> <td> follow-up 6 months<br> n=20/20<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9713.htm"> Janssens, 2006 </a> <br> </td> <td> stem cells mean 1.7 10^8<br>  <i>versus</i> <br> placebo (Saline and 5% autologous serum) </td> <td> patienst with successful percutaneous coronary intervention for STEMI </td> <td> follow-up 4 months<br> n=33/34<br> parallel group<br> double blind <br> </td> </tr> <tr> <td> <a href="../TRC_t9714.htm"> MAGIC Cell-3-DES (Kang), 2006 </a> <br> </td> <td> intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor (stem cells 1-2 10^9)<br>  <i>versus</i> <br> control </td> <td> patients with myocardial infarction who underwent coronary revascularization with DES for the culprit lesion </td> <td> follow-up 6 months<br> n=25/25<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9715.htm"> Karpov, 2005 </a> <br> </td> <td> intracoronary injection of bone marrow mononuclear cells (stem cells mean 88.5 10^6)<br>  <i>versus</i> <br> control </td> <td> patients with acute myocardial infarction. </td> <td> follow-up 6 months<br> n=10/10<br> parallel group<br> NA <br> </td> </tr> <tr> <td> <a href="../TRC_t9716.htm"> Li, 2007 </a> <br> </td> <td> autologous peripheral blood stem cell transplantation by intracoronary infusion (stem cells mean 7.25 10^7)<br>  <i>versus</i> <br> control </td> <td> patients with AMI </td> <td> follow-up 6 months<br> n=35/23<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9717.htm"> ASTAMi (Lunde), 2006 </a> <br> </td> <td> intracoronary injection of autologous mononuclear BMC (stem cells 0.68 10^8)<br>  <i>versus</i> <br> control (Heparanized plasma) </td> <td> patients with acute ST-elevation myocardial infarction of the anterior wall treated with percutaneous coronary intervention </td> <td> follow-up 6 months<br> n=50/50<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9718.htm"> Meluzin LD, 2006 </a> <br> </td> <td> intracoronar mononuclear bone marrow cells (stem cells 10^7)<br>  <i>versus</i> <br> control (Cell suspension media) </td> <td> patients with a first acute myocardial infarction </td> <td> follow-up 3 months<br> n=22/22<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9719.htm"> Meluzin HD, 2006 </a> <br> </td> <td> intracoronar mononuclear bone marrow cells (stem cells 10^8)<br>  <i>versus</i> <br> control (Cell suspension media) </td> <td> patients with a first acute myocardial infarction </td> <td> follow-up 3 months<br> n=22/22<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9720.htm"> BOOSt (Meyer), 2004 </a> <br> </td> <td> stem cells mean 2.46 10^9<br>  <i>versus</i> <br> control(Heparanised plasma) </td> <td> successful percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction </td> <td> follow-up 6 months<br> n=30/30<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9721.htm"> Penicka, 2007 </a> <br> </td> <td> Intracoronary injection of autologous bone marrow-derived mononuclear cells (stem cells 26.4 10^8)<br>  <i>versus</i> <br> control </td> <td> patients with large anterior acute myocardial infarction </td> <td> follow-up 4 months<br> n=14/10<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9722.htm"> Ruan, 2005 </a> <br> </td> <td> intracoronary injection of bone-marrow cell (stem cells dose NA)<br>  <i>versus</i> <br> control (Diluted serum) </td> <td> with acute myocardial infarction and anterior descending coronary artery occlusion proven by angiography </td> <td> follow-up 6 months<br> n=9/11<br> parallel group<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9723.htm"> REPAIR-AMI (Schachinger), 2006 </a> <br> NCT00279175 </td> <td> intracoronary infusion of progenitor cells derived from bone marrow (stem cells mean 2.36 10^8)<br>  <i>versus</i> <br> placebo (X-vivo media and 20% autologous serum) </td> <td> patients with acute myocardial infarction </td> <td> follow-up 4 months<br> n=95/92<br> <br> double blind <br> </td> </tr> <tr> <td> <a href="../TRC_t9725.htm"> Suzuki, 2006 </a> <br> </td> <td> granulocyte colony stimulating factor (G-CSF)<br>  <i>versus</i> <br> control </td> <td> patients with angina or AMI </td> <td> follow-up 6 months<br> n=-9/-9<br> <br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9598.htm"> CADUCEUS, </a> <br> NCT00893360 </td> <td> Autologous cardiosphere-derived stem cell intra-coronary infusion<br>  <i>versus</i> <br> control </td> <td> patients with ischemic left ventricular dysfunction and a recent myocardial infarction </td> <td> follow-up 12 months<br> n=-9/-9<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t9911.htm"> NCT00975234, </a> <br> NCT00975234 </td> <td> Intra-lesion injection of autologous skeletal myoblasts<br>  <i>versus</i> <br> placebo </td> <td> Patients With Old Myocardial Infarction </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="../TRC_t9969.htm"> MARVEL, </a> <br> </td> <td> autologous myoblasts by intramyocardial injection at doses containing 400 or 800 million cells<br>  <i>versus</i> <br> sham procedure </td> <td> patients with post-MI myocardial scarring </td> <td> follow-up 6 mo<br> n=14/6<br> Parallel groups<br> double blind <br> </td> </tr> </table> <h2>References</h2> <p> <b>REVIVAL-2 (Zohlnhöfer ), 2006 : </b> Zohlnhöfer D, Ott I, Mehilli J, Schömig K, Michalk F, Ibrahim T, Meisetschläger G, von Wedel J, Bollwein H, Seyfarth M, Dirschinger J, Schmitt C, Schwaiger M, Kastrati A, Schömig AStem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial. <i>JAMA 2006;295:1003-10</i> [PMID 16507801] </p> <p> <b>STEMMI (Ripa), 2006 : </b> Ripa RS, Jørgensen E, Wang Y, Thune JJ, Nilsson JC, Søndergaard L, Johnsen HE, Køber L, Grande P, Kastrup JStem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial. <i>Circulation 2006;113:1983-92</i> [PMID 16531621] </p> <p> <b>G-CSF-STEMI (Engelmann), 2006 : </b> Engelmann MG, Theiss HD, Hennig-Theiss C, Huber A, Wintersperger BJ, Werle-Ruedinger AE, Schoenberg SO, Steinbeck G, Franz WMAutologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after subacute ST-segment elevation myocardial infarction undergoing late revascularization: final results from the G-CSF-STEMI (Granulocyte Colony-Stimulating Factor ST-Segment Elevation Myocardial Infarction) trial. <i>J Am Coll Cardiol 2006;48:1712-21</i> [PMID 17045910] </p> <p> <b>FIRSTLINE-AMI (Ince), 2005 : </b> Ince H, Petzsch M, Kleine HD, Eckard H, Rehders T, Burska D, Kische S, Freund M, Nienaber CAPrevention of left ventricular remodeling with granulocyte colony-stimulating factor after acute myocardial infarction: final 1-year results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-AMI) Trial. <i>Circulation 2005;112:I73-80</i> [PMID 16159869] </p> <p> <b>MAGIC Cell-3-DES (Kang), 2006 : </b> Kang HJ, Lee HY, Na SH, Chang SA, Park KW, Kim HK, Kim SY, Chang HJ, Lee W, Kang WJ, Koo BK, Kim YJ, Lee DS, Sohn DW, Han KS, Oh BH, Park YB, Kim HSDifferential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial. <i>Circulation 2006;114:I145-51</i> [PMID 16820564] </p> <p> <b>MAGIC (G-CSF) (Kang), 2004 : </b> Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, Kim YJ, Soo Lee D, Sohn DW, Han KS, Oh BH, Lee MM, Park YBEffects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. <i>Lancet 2004;363:751-6</i> [PMID 15016484] </p> <p> <b>MAGIC 1 (Kang), 2007 : </b> Kang HJ, Kim HS, Koo BK, Kim YJ, Lee D, Sohn DW, Oh BH, Park YBIntracoronary infusion of the mobilized peripheral blood stem cell by G-CSF is better than mobilization alone by G-CSF for improvement of cardiac function and remodeling: 2-year follow-up results of the Myocardial Regeneration and Angiogenesis in Myocardial Infarction with G-CSF and Intra-Coronary Stem Cell Infusion (MAGIC Cell) 1 trial. <i>Am Heart J 2007;153:237.e1-8</i> [PMID 17239682] </p> <p> <b>Valgimigli, 2005 : </b> Valgimigli M, Rigolin GM, Cittanti C, Malagutti P, Curello S, Percoco G, Bugli AM, Della Porta M, Bragotti LZ, Ansani L, Mauro E, Lanfranchi A, Giganti M, Feggi L, Castoldi G, Ferrari R <i>Eur Heart J 2005;26:1838-45</i> [PMID 15860518] 10.1093/eurheartj/ehi289 </p> <p> <b>Ellis, 2006 : </b> Ellis SG, Penn MS, Bolwell B, Garcia M, Chacko M, Wang T, Brezina KJ, McConnell G, Topol EJGranulocyte colony stimulating factor in patients with large acute myocardial infarction: results of a pilot dose-escalation randomized trial. <i>Am Heart J 2006;152:1051.e9-14</i> [PMID 17161051] 10.1016/j.ahj.2006.09.003 </p> <p> <b>Ellis, 2006 : </b> Ellis SG, Penn MS, Bolwell B, Garcia M, Chacko M, Wang T, Brezina KJ, McConnell G, Topol EJGranulocyte colony stimulating factor in patients with large acute myocardial infarction: results of a pilot dose-escalation randomized trial. <i>Am Heart J 2006;152:1051.e9-14</i> [PMID 17161051] 10.1016/j.ahj.2006.09.003 </p> <p> <b>Takano, 2007 : </b> Takano H, Hasegawa H, Kuwabara Y, Nakayama T, Matsuno K, Miyazaki Y, Yamamoto M, Fujimoto Y, Okada H, Okubo S, Fujita M, Shindo S, Kobayashi Y, Komiyama N, Takekoshi N, Imai K, Himi T, Ishibashi I, Komuro IFeasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction. <i>Int J Cardiol 2007;122:41-7</i> [PMID 17182126] 10.1016/j.ijcard.2006.11.016 </p> <p> <b>RIGENERA (Leone), 2007 : </b> Leone AM, Galiuto L, Garramone B, Rutella S, Giannico MB, Brugaletta S, Perfetti M, Liuzzo G, Porto I, Burzotta F, Niccoli G, Biasucci LM, Leone G, Rebuzzi AG, Crea FUsefulness of granulocyte colony-stimulating factor in patients with a large anterior wall acute myocardial infarction to prevent left ventricular remodeling (the rigenera study). <i>Am J Cardiol 2007;100:397-403</i> [PMID 17659916] 10.1016/j.amjcard.2007.03.036 </p> <p> <b>Suarez de Lezo (G-CSF), 2007 : </b> Suárez de Lezo J, Herrera C, Pan M, Romero M, Pavlovic D, Segura J, Sánchez J, Ojeda S, Torres A[Regenerative therapy in patients with a revascularized acute anterior myocardial infarction and depressed ventricular function] <i>Rev Esp Cardiol 2007;60:357-65</i> [PMID 17521544] </p> <p> <b>MAGIC (cell infusion ), 2004 : </b> Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, Kim YJ, Soo Lee D, Sohn DW, Han KS, Oh BH, Lee MM, Park YBEffects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. <i>Lancet 2004;363:751-6</i> [PMID 15016484] </p> <p> <b>Suarez de Lezo (cell), 2007 : </b> Suárez de Lezo J, Herrera C, Pan M, Romero M, Pavlovic D, Segura J, Sánchez J, Ojeda S, Torres A <i>Rev Esp Cardiol 2007;60:357-65</i> [PMID 17521544] </p> <p> <b>TCT-STAMI (Ge), 2006 : </b> Ge J, Li Y, Qian J, Shi J, Wang Q, Niu Y, Fan B, Liu X, Zhang S, Sun A, Zou YEfficacy of emergent transcatheter transplantation of stem cells for treatment of acute myocardial infarction (TCT-STAMI). <i>Heart 2006;92:1764-7</i> [PMID 16775089] 10.1136/hrt.2005.085431 </p> <p> <b>Huang, 2006 : </b> Huang RC, Yao K, Zou YZ, Ge L, Qian JY, Yang J, Yang S, Niu YH, Li YL, Zhang YQ, Zhang F, Xu SK, Zhang SH, Sun AJ, Ge JB[Long term follow-up on emergent intracoronary autologous bone marrow mononuclear cell transplantation for acute inferior-wall myocardial infarction] <i>Zhonghua Yi Xue Za Zhi 2006;86:1107-10</i> [PMID 16796836] </p> <p> <b>Janssens, 2006 : </b> Janssens S, Dubois C, Bogaert J, Theunissen K, Deroose C, Desmet W, Kalantzi M, Herbots L, Sinnaeve P, Dens J, Maertens J, Rademakers F, Dymarkowski S, Gheysens O, Van Cleemput J, Bormans G, Nuyts J, Belmans A, Mortelmans L, Boogaerts M, Van de Werf FAutologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. <i>Lancet 2006;367:113-21</i> [PMID 16413875] 10.1016/S0140-6736(05)67861-0 </p> <p> <b>MAGIC Cell-3-DES (Kang), 2006 : </b> Kang HJ, Lee HY, Na SH, Chang SA, Park KW, Kim HK, Kim SY, Chang HJ, Lee W, Kang WJ, Koo BK, Kim YJ, Lee DS, Sohn DW, Han KS, Oh BH, Park YB, Kim HSDifferential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial. <i>Circulation 2006;114:I145-51</i> [PMID 16820564] 10.1161/CIRCULATIONAHA.105.001107 </p> <p> <b>Karpov, 2005 : </b> Karpov RS, Popov SV, Markov VA, Suslova TE, Ryabov VV, Poponina YS, Krylov AL, Sazonova SVAutologous mononuclear bone marrow cells during reparative regeneratrion after acute myocardial infarction. <i>Bull Exp Biol Med 2005;140:640-3</i> [PMID 16758644] </p> <p> <b>Li, 2007 : </b> Li ZQ, Zhang M, Jing YZ, Zhang WW, Liu Y, Cui LJ, Yuan L, Liu XZ, Yu X, Hu TSThe clinical study of autologous peripheral blood stem cell transplantation by intracoronary infusion in patients with acute myocardial infarction (AMI). <i>Int J Cardiol 2007;115:52-6</i> [PMID 16822566] 10.1016/j.ijcard.2006.04.005 </p> <p> <b>ASTAMi (Lunde), 2006 : </b> Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, Endresen K, Ilebekk A, Mangschau A, Fjeld JG, Smith HJ, Taraldsrud E, Grøgaard HK, Bjørnerheim R, Brekke M, Müller C, Hopp E, Ragnarsson A, Brinchmann JE, Forfang KIntracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. <i>N Engl J Med 2006;355:1199-209</i> [PMID 16990383] 10.1056/NEJMoa055706 </p> <p> <b>ASTAMi (Lunde), 2006 : </b> Beitnes JO, Hopp E, Lunde K, Solheim S, Arnesen H, Brinchmann JE, Forfang K, Aakhus 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