coronary artery disease - revascularization with drug eluting stent - long or complex lesion clinical trials results meta-analysis

<h1> <a href="TM29-79-revascularization with drug eluting stent-coronary artery disease" > <strong>coronary artery disease</strong> - revascularization with drug eluting stent </a> - long or complex lesion trial results systematic overview and meta-analysis </h1> <h2>Main characteristics of the included studies</h2> <table> <tr> <th>Trial</th> <th>Treatments</th> <th>Patients</th> <th>Methods</th> </tr> <tr> <td> <a href="../TRC_t6562.htm"> TAXUS V (all patients), 2005 </a> <br> NCT00301522 </td> <td> TAXUS<br>  <i>versus</i> <br> bare metal EXPRESS-2 </td> <td> Stable or unstable AP, silent ischaemia with single coronary artery stenosis including complex or previously unstudied lesions (requiring 2.25-mm, 4.0-mm, and/or multiple stents) </td> <td> follow-up 9 months<br> n=577/579<br> Parallel groups<br> double-blind <br> United States </td> </tr> <tr> <td> <a href="../TRC_t6571.htm"> PRISON II, 2006 </a> <br> NCT00258596 </td> <td> Cypher<br>  <i>versus</i> <br> BxVelocity </td> <td> Chronic total occlusion, positive exercise stress test </td> <td> follow-up 6 months<br> n=100/100<br> Parallel groups<br> single-blind <br> Belgium </td> </tr> <tr> <td> <a href="../TRC_t6572.htm"> SCANDSTENT, 2006 </a> <br> NCT00151658 </td> <td> Cypher<br>  <i>versus</i> <br> Sonic </td> <td> Stable or unstable AP, recent AMI (non ST-elevation); with one or more de novo complex lesions in native coronary vessels (occluded, bifurcational, ostial or angulated) </td> <td> follow-up 7 months<br> n=163/159<br> Parallel groups<br> open <br> Denmark </td> </tr> <tr> <td> <a href="../TRC_t6584.htm"> CORPAL, 2005 </a> <br> </td> <td> sirolimus<br>  <i>versus</i> <br> paclitaxel </td> <td> Documented myocardial ischaemia, no AMI </td> <td> follow-up <br> n=331/321<br> Parallel groups<br> open <br> Spain </td> </tr> <tr> <td> <a href="../TRC_t6588.htm"> LONG DES II, 2006 </a> <br> </td> <td> SES<br>  <i>versus</i> <br> PES </td> <td> Long lesions. AP or positive stress, no AMI </td> <td> follow-up 9 months<br> n=250/250<br> Parallel groups<br> single-blind <br> Korea </td> </tr> <tr> <td> <a href="../TRC_t6641.htm"> SYNTAX, 2009 </a> <br> NCT00114972 </td> <td> paclitaxel (taxus Express SR)<br>  <i>versus</i> <br> Coronary Artery Bypass Surgery (on- or off-pump bypass) </td> <td> patients with previously untreated three-vessel or left main coronary artery disease (or both) (complex lesions) </td> <td> follow-up 1 year<br> n=903/897<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="../TRC_t7184.htm"> TRIAS-HR, 2008 </a> <br> ISRCTN74297220 </td> <td> Genous stent (antibody-coated bare-metal stent) followed by one month of dual antiplatelet therapy<br>  <i>versus</i> <br> Taxus or Cypher followed by at least six months of dual antiplatelet therapy </td> <td> high-risk patients (long lesions, small vessels, chronic total occlusions, or any lesion in a diabetic patient) </td> <td> follow-up 12 months<br> n=98/95<br> Parallel groups<br> single-blind <br> </td> </tr> </table> <h2>References</h2> <p> <b>TAXUS V (all patients), 2005 : </b> Stone GW, Ellis SG, Cannon L, Mann JT, Greenberg JD, Spriggs D, O'Shaughnessy CD, DeMaio S, Hall P, Popma JJ, Koglin J, Russell MEComparison of a polymer-based paclitaxel-eluting stent with a bare metal stent in patients with complex coronary artery disease: a randomized controlled trial. <i>JAMA 2005;294:1215-23</i> [PMID 16160130] </p> <p> <b>PRISON II, 2006 : </b> Suttorp MJ, Laarman GJ, Rahel BM, Kelder JC, Bosschaert MA, Kiemeneij F, Ten Berg JM, Bal ET, Rensing BJ, Eefting FD, Mast EGPrimary Stenting of Totally Occluded Native Coronary Arteries II (PRISON II): a randomized comparison of bare metal stent implantation with sirolimus-eluting stent implantation for the treatment of total coronary occlusions. <i>Circulation 2006;114:921-8</i> [PMID 16908768] </p> <p> <b>SCANDSTENT, 2006 : </b> Kelbaek H, Thuesen L, Helqvist S, Klvgaard L, Jrgensen E, Aljabbari S, Saunamki K, Krusell LR, Jensen GV, Btker HE, Lassen JF, Andersen HR, Thayssen P, Galle A, van Weert AThe Stenting Coronary Arteries in Non-stress/benestent Disease (SCANDSTENT) trial. <i>J Am Coll Cardiol 2006;47:449-55</i> [PMID 16412876] </p> <p> <b>SCANDSTENT, 2006 : </b> Kelbaek H, Klvgaard L, Helqvist S, Lassen JF, Krusell LR, Engstrm T, Btker HE, Jrgensen E, Saunamki K, Aljabbari S, Thayssen P, Galle A, Jensen GV, Thuesen LLong-term outcome in patients treated with sirolimus-eluting stents in complex coronary artery lesions: 3-year results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) trial. <i>J Am Coll Cardiol 2008 May 27;51:2011-6</i> [PMID 18498953] </p> <p> <b>CORPAL, 2005 : </b> de Lezo J, Medina A, Pan M, et al.de Lezo J, Medina A, Pan M, et al. Drug-eluting stent for complexlesions: latest angiographic data from randomized rapamycinversus paclitaxel CORPAL study <i>J Am Coll Cardiol 2005; 45: 75A.</i> [PMID ] </p> <p> <b>LONG DES II, 2006 : </b> Kim YH, Park SW, Lee SW, Park DW, Yun SC, Lee CW, Hong MK, Kim HS, Ko JK, Park JH, Lee JH, Choi SW, Seong IW, Cho YH, Lee NH, Kim JH, Chun KJ, Park SJSirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease. <i>Circulation 2006;114:2148-53</i> [PMID 17060388] </p> <p> <b>SYNTAX, 2009 : </b> Lee TH, Hillis LD, Nabel EG <i>N Engl J Med 2009;360:e10</i> [PMID 19228613] </p> <p> <b>SYNTAX, 2009 : </b> Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, Ståhle E, Feldman TE, van den Brand M, Bass EJ, Van Dyck N, Leadley K, Dawkins KD, Mohr FW <i>N Engl J Med 2009;:</i> [PMID 19228612] </p> <p> <b>SYNTAX, 2009 : </b> Banning AP, Westaby S, Morice MC, Kappetein AP, Mohr FW, Berti S, Glauber M, Kellett MA, Kramer RS, Leadley K, Dawkins KD, Serruys PWDiabetic and nondiabetic patients with left main and/or 3-vessel coronary artery disease: comparison of outcomes with cardiac surgery and paclitaxel-eluting stents. <i>J Am Coll Cardiol 2010;55:1067-75</i> [PMID 20079596] 10.1016/j.jacc.2009.09.057 </p>